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’s pathological progression to death. Meanwhile, its fibrosis degree affects renal function ( 1 , 2 ). Silent information regulator factor 2-related enzyme 1 (Sirt1), as a key factor in regulating energy metabolism, exerts a nephroprotective effect by mediating
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worldwide ( 3 ). Depression is an important cause of disability and has a significant impact on quality of life and body function, posing a serious threat to public health ( 4 ). Depression is also a major factor in the global burden of diseases, leading to
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. Diabetic Medicine 1995 12 129 – 133 . ( https://doi.org/10.1111/j.1464-5491.1995.tb00443.x ) 2 Mauras N Merimee T & Rogol AD . Function of the growth hormone-insulin-like growth factor i axis in the profoundly growth-retarded diabetic child
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Institute of Epidemiology and Medical Biometry, ZIBMT, Ulm University, Ulm, Germany
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Institute of Epidemiology and Medical Biometry, ZIBMT, Ulm University, Ulm, Germany
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in adipose tissue development or function (lipodystrophy (LD)) or primary disorders of insulin signaling ( 1 , 2 , 3 ). LDs are rare heterogeneous disorders characterized by selective loss of body fat and can be divided into congenital and