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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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identified as having prediabetes, a disorder that substantially increases the risk for diabetes ( 4 ). Thus, identification of relevant blood-based biomarkers allowing risk stratification in obese patients is required. As sex-specific differences in glucose
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Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
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Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Pharmacology, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
Copenhagen Center for Translational Research, Copenhagen University Hospital – Bispebjerg and Frederiksberg, University of Copenhagen, Copenhagen, Denmark
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Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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procedures used. The two main groups were carefully matched on age, sex, and BMI and differed significantly only on HbA1c and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). The two main groups were intentionally recruited to provide two
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Xiamen Key Laboratory for Clinical Efficacy and Evidence-Based Research of Traditional Chinese Medicine, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
Fujian Province Key Laboratory of Diabetes Translational Medicine, The First Affiliated Hospital of Xiamen University, School of medicine, Xiamen University, Xiamen, China
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the early-onset T2DM group, and this disproportion became larger by years consistently. This sex-specific difference was not found in the late-onset group. Table 1 Sex-specific difference in glucose-lowering medicine prescription. Year
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cancer cells as direct activators of estrogen receptor alpha . Cancer Research 1999 59 4864 – 4869 . 41 Ding EL Song Y Malik VS Liu S . Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta
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.9%, without sex differences ( 1 ). This trend has increased significantly during the coronavirus-19 pandemic, and the prevalence of diabetes has also increased continuously in recent years ( 2 ). According to the World Health Organization (WHO), the global
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.1016/j.jdiacomp.2017.04.006 ) 32 Meyer MR Clegg DJ Prossnitz ER Barton M . Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors . Acta Physiologica 2011 203 259 – 269 . ( https://doi.org/10.1111/j.1748
German Center for Diabetes Research (DZD), Neuherberg, Germany
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German Center for Diabetes Research (DZD), Neuherberg, Germany
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Department of Internal Medicine IV, University Hospital Tübingen, Germany
Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
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Division of Endocrinology and Diabetology, Department of Internal Medicine 1, University Hospital Ulm, Ulm, Germany
Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen, Tübingen, Germany
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Institute of Health Services Research and Health Economics, Center for Health and Society, Faculty of Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Institute of Health Services Research and Health Economics, German Diabetes Center (DDZ), Leibniz Centre for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
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Department of Psychiatry and Psychotherapy II, University Hospital Ulm, Um, Germany
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German Center for Diabetes Research (DZD), Neuherberg, Germany
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German Center for Diabetes Research (DZD), Neuherberg, Germany
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.41). Figure 4 Proportion of inpatient cases with a COVID-19 diagnosis in 2020 by sex and age group : Difference between cases with and without diabetes. *Significant ( P < 0.01); n.s., not significant (Chi-square test). Discussion This
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-SDS, height-SDS, BMI-SDS for age and sex were also obtained using the reference data for Italian population ( 17 ). Pubertal stage was defined according to Tanner’s stage for both sexes ( 18 ). Laboratory procedures and glycemic variability indexes In
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(age, sex, socioeconomic variables, type of eligibility, and so on), a medical treatment database (based on medical bills claimed by medical service providers for medical expenses), a health examination database (general health examinations and
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continuous variables. Differences between the subjects in NGT and IGR groups were assessed by either an independent sample t -test (numerical variables of normal distribution) or Mann–Whitney U test (numerical variables of skewed distribution). The chi