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mechanisms mainly include metformin, thiazolidinediones (TZDs) α-glucosidase inhibitors, and sodium–glucose cotransporter 2 inhibitors (SGLT2i). The formation of serum uric acid (SUA) is the ribose 5-phosphate, a pentose derived from glycidic metabolism
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closely related to the kidneys function, such as ACR (mg/g), serum creatinine (mg/dL), serum uric acid (mg/dL), eGFR (mL/min/1.73 m 2 ), and others related to obesity, metabolism, such as total cholesterol (mg/dL), triglycerides (mg/dL), high
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Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China
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(SCR in μmol/L), blood uric acid (UA in μmol/L), glycated hemoglobin (HbA1c in %), urinary microalbumin (mg/dL), urinary creatinine (μmol/L), and calculate urinary albumin to creatinine ratio (ACR in mg/g) and glomerular filtration rate (eGFR in mL
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and diastolic blood pressure (SBP and DBP)) measured three times in the right arm at intervals of 30 s using an electronic sphygmomanometer (HEM-770AFuzzy, Omron, Kyoto, Japan), and clinical and biochemical measures (levels of FPG, serum uric acid (UA
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peptidase-4 inhibitors (DPP-4Is), SGLT-2Is and glucagon-like peptide-1 receptor agonists (GLP-1RAs). Fasting venous blood samples were taken to detect biochemical indices, such as serum CysC levels, hepatic function index, creatinine, uric acid (UA), lipid
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range from 0 to 100. Laboratory examination and calculation An automated biochemical analyzer (Model 7600, Hitachi) was used to detect lipid profiles, blood urea nitrogen, creatinine, cystatin C and uric acid (UA) levels. An ion exchange
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transpeptidase (GGT), total bilirubin (TBIL), blood urea nitrogen (BUN), lactate dehydrogenase (LDH), albumin (ALB), globulin (GLB), creatinine (Cre), uric acid (UA), Na, and glucose (GLU), with all P values <0.001 ( Table 1 ). Table 1 Basic crowd
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, uric acid level, thyroid function, etc., were collected. Among them, the female ratio was higher in the SCH group (52.17% vs 40.98%, P = 0.036), which indicated that females might be more susceptible to subclinical thyroid disease. The renal
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-density lipoprotein; NEFA, non-esterified fatty acid; NGT, normal glucose tolerance; TC, total cholesterol; TG, triglycerides; TNF-α, tumor necrosis factor alpha; UA, uric acid; WC, waist circumference. In addition, areas under the receiver operating
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-C), total cholesterol (TC), triglycerides, γ-GT, GOT, GPT, blood urea nitrogen, creatinine, uric acid, TSH, HbA1c, fasting glucose and fasting plasma insulin. Insulin resistance (IR) was calculated using the homeostatic model assessment (HOMA) according to