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developing personalized treatment strategies tailored to individual tumor profiles. CRISPR/Cas9-based epigenome editing The CRISPR/Cas9 technology has enabled targeted studies of gene function in thyroid cancer ( 88 , 89 ). Researchers have used this
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital/ University Medical Center Utrecht, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
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Developmental Endocrinology Research Group, Royal Hospital for Children, University of Glasgow, Glasgow, UK
Office for Rare Conditions, University of Glasgow, Glasgow, UK
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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primary malignancies ( 16 , 17 , 18 ). With current treatment strategies, the overall survival in pediatric patients with DTC is excellent. This excellent survival raises the question whether treatment may be given less ‘aggressively’ aiming to reduce
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Emma Children’s Hospital, Amsterdam UMC, Department of Pediatrics, Amsterdam, The Netherlands
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University Hospital Würzburg, Department of Nuclear Medicine, Würzburg, Germany
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made by the healthcare provider in consultation with the survivor after careful consideration of the advantages and disadvantages of the two modalities. As all surveillance strategies will result in some false-positive results, attention must be paid
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Université Libre de Bruxelles, Bruxelles, Belgium
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School of Medicine, Zagreb, Croatia
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Department of Clinical Nutrition, Landspitali-National University Hospital, Reykjavik, Iceland
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Goldman School of Medicine, Ben Gurion University of the Negev, Beer Sheva, Israel
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Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
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Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
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Universitat Autònoma de Barcelona, Barcelona, Spain
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Frölunda Specialist Hospital, Västra Frölunda, Sweden
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Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Wallenberg Centre of Molecular and Translational Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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registries related to health insurance. Ideally, for use in research projects, a register should cover the entire country/region or a large, well-defined sub-population whereby it is representative, and the data should be of acceptable validity ( 2
Department of Ultrasound, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China
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result, preoperative lymph node metastatic detection is critical for surgical strategy selection ( 4 ). In individuals with PTC, conventional ultrasound (US) examination was the preferred preoperative examination. Because the standard US has a high
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operative times, and delayed referrals, thus advocating for iOPTH monitoring. Future research is needed to refine strategies for diagnosing and managing PHPT. Declaration of interest The authors declare that there is no conflict of interest that
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function in men with DTC. Materials and methods Retrieval strategy The PubMed, Embase, Web of Science, OVID, Scopus, and Wanfang databases were searched from inception to June 2022 to identify published studies related to radioiodine therapy and
Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
Key Laboratory of TCM Syndrome and Treatment of Yingbing (Thyroid Disease) of State Administration of Traditional Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
Key Laboratory of TCM Syndrome and Treatment of Yingbing (Thyroid Disease) of State Administration of Traditional Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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, and therapeutic strategies. Interestingly, a meta-analysis involving 13 clinical studies has demonstrated that male gender, multifocality, tumor size > 5 mm, and extrathyroidal extension are reliable predictors of central lymph node metastasis in CN0
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School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China
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Quanzhou Medical College, Quanzhou, Fujian, China
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upon thyroid cells, triggering subsequent cell death ( 3 ). Consequently, there is a reduction in thyroid hormone synthesis and secretion. Some researchers posit that the response of GD patients to RAI therapy correlates with the sensitivity of thyroid
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instances, personalized and comprehensive treatment strategies become imperative, demanding vigilant monitoring and proactive intervention. The underpinning mechanism of liver failure in hyperthyroid patients involves heightened oxygen consumption due to