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María Dolores Rodríguez Arnao, Amparo Rodríguez Sánchez, Ignacio Díez López, Joaquín Ramírez Fernández, Jose Antonio Bermúdez de la Vega, Diego Yeste Fernández, María Chueca Guindulain, Raquel Corripio Collado, Jacobo Pérez Sánchez, Ana Fernández González, and ECOS Spain Study Collaborative Investigator Group

Introduction Since the 60s, GH has been the mainstay of treatment for children with GH deficiency (GHD) ( 1 ). With the discovery of recombinant human growth hormone (r-hGH), the treatment has been extended to other conditions, such as Turner

Open access

Pinaki Dutta, Bhuvanesh Mahendran, K Shrinivas Reddy, Jasmina Ahluwalia, Kim Vaiphei, Rakesh K Kochhar, Prakamya Gupta, Anand Srinivasan, Mahesh Prakash, Kanchan Kumar Mukherjee, Viral N Shah, Girish Parthan, and Anil Bhansali

hormones are intact or properly replaced (4, 5, 6) . In addition, GH replacement in these subjects has been shown to reverse many of the abnormalities (7) . There is a paucity of data on recombinant human GH (r-hGH) replacement therapy in acromegaly

Open access

Jessica S Jarmasz, Yan Jin, Hana Vakili, and Peter A Cattini

Introduction Human (h) growth hormone (GH) is synthesized and secreted in a pulsatile manner by somatotrophs located in the anterior pituitary ( 1 ). Following the successful isolation and purification of hGH in 1944, GH secretion in humans

Open access

Juliane Léger, Anne Fjellestad-Paulsen, Anne Bargiacchi, Catherine Doyen, Emmanuel Ecosse, Jean-Claude Carel, and Marie-France Le Heuzey

are at least partially reversed during refeeding and recovery ( 19 ). The effects of supraphysiological levels of human GH on HV in these patients remain unclear. The administration of supraphysiological doses of hGH for four weeks is well tolerated

Open access

Robert Rapaport, Jan M Wit, and Martin O Savage

to rhGH. Genetic identification of IGF1R defects can be compared to published experience of rhGH therapy in such patients ( 73 ) rather than to non-specific responses to hGH in idiopathic SGA subjects. The new development of C-type natriuretic

Open access

Kennett Sprogøe, Eva Mortensen, David B Karpf, and Jonathan A Leff

:// ) 66 Kang J Kim P Kwak EH Xu M-Y Han O Kim Y Jung SY Kwon S Huh Y Chapel S . 6 month results of a phase II, randomized, active controlled, open label study of safety and efficacy of HM10560A a long acting r-Hgh-HMbib1

Open access

Justyna Modrzynska, Christine F Klein, Kasper Iversen, Henning Bundgaard, Bolette Hartmann, Maike Mose, Nikolaj Rittig, Niels Møller, Jens J Holst, and Nicolai J Wewer Albrechtsen

surgery within 14 days prior to the study inclusion were excluded from the study population. All patients provided written informed consent. The study protocol was approved by the Data Protection Agency (HGH-2015-010, I-suite no: 03923) and the Danish

Open access

Marko Stojanovic, Zida Wu, Craig E Stiles, Dragana Miljic, Ivan Soldatovic, Sandra Pekic, Mirjana Doknic, Milan Petakov, Vera Popovic, Christian Strasburger, and Márta Korbonits

. Hormonal analysis All serum samples were stored at −80°C until analysed for GH, cortisol and PRL at the Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia. GH was measured by immunoradiometric assay HGH-RIA CT Cisbio

Open access

Ekaterina Koledova, George Stoyanov, Leroy Ovbude, and Peter S W Davies

R. Adherence in children with growth hormone deficiency treated with r-hGH and the easypod device . Journal of Endocrinological Investigation 2016 39 1419 – 1424 . ( ) 27406716 10.1007/s40618

Open access

Rossella Cannarella, Andrea Crafa, Sandro La Vignera, Rosita A Condorelli, and Aldo E Calogero

Zebrafish ( 5 ). Furthermore, we have recently shown that the growth hormone receptor (GHR) and the IGF1 receptor (IGF1R) are both expressed in the Gn11 and the GT1-7 cell lines. The incubation with either GH or IGF1 stimulated Gn11 cell migration and GnRH