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, FSH, E2, progesterone and testosterone. The degree of insulin resistance was assessed by the Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), which was calculated using the formula FBG × FINS/22.5. FBG was estimated by the glucose oxidase
Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
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Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK
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Centre for Endocrinology, William Harvey Research Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK
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Department of Paediatric Endocrinology, Makarios Children's Hospital, Nicosia, Cyprus
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Sussex Community NHS Trust, Brighton, UK
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Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
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The University of Dublin, Trinity College Dublin, Dublin, Republic of Ireland
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bleeds are achieved, a progesterone should be added as per BSPED guidelines. In adults, either 17β-oestradiol patches (e.g. Evorel © ) or topical oestrogen gel (Sandrena © ) are preferred, especially if there is severe obesity or hypertension. Oral