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. Platelet parameters may be promising biomarkers for predicting early signs of metabolic abnormalities. The pathophysiology of MetS includes inflammation, insulin resistance, oxidative stress and endothelial dysfunction and triggers platelet hyperactivity
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intrapartum. To avoid the platelet swelling induced by EDTA, blood samples were analyzed within half an hour of collection ( 28 ). An automated blood counter was used to measure complete blood count (CBC) parameters including MPV. Blood clotting time
Faculté de Chirurgie Dentaire, Université de Toulouse III, Toulouse, France
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CHU de Toulouse, Laboratoire d’Hématologie, Toulouse, France
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Faculté de Chirurgie Dentaire, Université de Toulouse III, Toulouse, France
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showed that chronic CE, BZA and CE + BZA had no or only very modest impact on these parameters ( Table 1 ). Table 1 Hematological parameters. OVX BZA CE CE + BZA Platelet count 554 ± 115 493 ± 40.5 385 ± 145* 512
Department of Endocrinology and Diabetes, Pakistan Kidney and Liver Institute and Research Centre, Knowledge City, Lahore, Pakistan
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Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland
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), vascular cell adhesion molecule 1 (VCAM-1), E-selectin, endoglin and vascular endothelial growth factor (VEGF) ( 9 , 10 , 11 , 12 , 13 ). Techniques to measure EMPs rely on the preparation of platelet-free plasma and subsequent identification of cell
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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after radical resections. Though several parameters, such as lymph node metastasis, vascular invasion and tumor grade, have been demonstrated to be important prognostic predictors, these markers could be only assessed postoperatively ( 5 ). Limited
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, the Netherlands
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Department of Plasma Proteins, Sanquin Research, Amsterdam, the Netherlands
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Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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-centrifuged, for 15 min at 3000 rpm (1860 g ) at 15°C to obtain platelet-poor plasma. Plasma was aliquoted and stored at −80°C until further use. Measurement of coagulation and fibrinolysis parameters was performed in one batch at the Department of Experimental
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Internal Medicine, Endocrine Unit, Herlev Gentofte Hospital, Herlev, Denmark
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Department of Internal Medicine, Endocrine Unit, Herlev Gentofte Hospital, Herlev, Denmark
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Department of Internal Medicine, Endocrine Unit, Herlev Gentofte Hospital, Herlev, Denmark
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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(Thrombinoscope BV, Maastricht, The Netherlands) using a fluorogenic method. After activation of the coagulation by adding tissue factor and phospholipids to platelet poor plasma, four parameters were measured: time to start of thrombin generation (lag time, min
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the improvement of iron homeostasis parameters ( 10 , 11 ). So far, data concerning the role of hepcidin in hyperthyroidism are sparse and ambiguous, which might be related to the diverse aetiology and severity of thyroid disease among the studied
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do not exhibit uniformity across patients, necessitating personalized therapeutic approaches and sustained support akin to other complex chronic conditions ( 16 ). Therefore, there is an urgent requirement for a validated and accurate parameter to
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model was conducted for parameters shown to be significant in the univariate analysis. Statistical analysis software JMP (version 12; SAS Institute Inc., Cary, NC) was used for statistical analyses and a P -value of <0.05 was considered statistically