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days before operation, whereas the control group was administered a placebo. The placebo was consistent in appearance with calcium carbonate and alfacalcidol. The serum calcium, phosphorus, and PTH concentrations were reevaluated in all patients on the
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Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
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Randomized, prospective, and double-blinded RTX 2 × 1000 mg 13 20 (9–60) 4.9 (1.0) 3.7 (1.9) 2 4/13 at week 24 No significant difference between groups in disease severity No data 5 moderate/severe Placebo n.a. 12 19.5 (2
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that LT4 initiated preconceptionally and continued throughout pregnancy did not decrease the risk of pregnancy loss or preterm delivery as compared to placebo, neither in spontaneous nor in vitro fertilization (IVF) obtained pregnancies ( 14 , 15
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placebo is an additional source of bias, as it is unclear if other drugs over GLP-1RAs may have protective, neutral, or detrimental effects on thyroid carcinogenesis. Third, the incidence of thyroid cancer ranks ninth worldwide. Although it is more
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found no difference in the live birth rate between LT4 and placebo groups ( 45 , 46 ). With regard to observational data, a large ( n = 984 pregnancies), prospective study found a high rate of miscarriage in euthyroid TPOAb+ women who did not receive
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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for GO. In placebo-controlled Phase III clinical trials, they reported that Tepezza exhibited a rapid reduction in proptosis and clinical activity scores compared to placebo for moderate-to-severe GO ( 41 ). In this study, we demonstrate that PBMCs
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I Daffini L Formenti A Iacobello C Cristiano A Gandossi E Agabiti Rosei E Castellano M . A double-blind placebo controlled trial of liquid thyroxine ingested at breakfast: results of the TICO Study . Thyroid 2016 26 197 – 202
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Pediatric Endocrinology Unit, Department of Women's and Children's Health, Padua University Hospital, Padova, Italy
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induces thyroid autoimmunity in patients with endemic goitre: a randomised, double-blind, placebo-controlled trial . European Journal of Endocrinology 1998 139 290 – 297 . ( https://doi.org/10.1530/EJE.0.1390290 ) 30 Giassa Τ Mamali I Gaki Ε