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supporting the effect of ADT on emotional regulation and affect however, is less clear ( 11 ). In a randomized controlled trial there was no difference in depressive symptoms between hypogonadal patients receiving testosterone and patients receiving placebo
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12615000778583). Experimental design Fifteen patients were randomised to receive either metformin or placebo first using a computer random assignment programme. Each treatment was for 6 weeks. Study endpoints were assessed at baseline, after 6 weeks of
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, randomized, two arms, double blind, placebo controlled, active – not recruiting OS Placebo: 29.0% OS Pazopanib: 37.1% (clinicaltrials.gov) N/A Pembrolizumab, Trametinib and Dabrafenib NCT04675710 Pembrolizumab: PD-1 receptor Dabrafenib: BRAF V
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(SANET-ep): a randomised, double-blind, placebo-controlled, phase 3 study . Lancet. Oncology 2020 21 1500 – 1512 . ( https://doi.org/10.1016/S1470-2045(2030496-4 ) 37 Xu J Shen L Bai C Wang W Li J Yu X Li Z Li E Yuan X Chi Y , et
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Tomasek J Raderer M Lahner H Voi M Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study . Lancet 2016 387 968 – 977
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suppressed ( 11 ). In a study on men assigned to either placebo or 1 month of GnRH antagonist in the absence or presence of testosterone, the main finding was similar; when the testosterone levels decreased also PSA dropped but completely recovered one month