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year of life with high penetrance. These included bilateral adrenal pheochromocytoma, multiple extra-adrenal pheochromocytomas, bilateral medullary thyroid cell neoplasia, bilateral parathyroid hyperplasia, and pituitary adenoma. The appearance of these
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cascades menin participates in ( 12 ). Menin in the development of bone disorders in MEN1 patients Parathyroid lesions in MEN1 manifest with PHPT, usually followed by hypersecretion of parathyroid hormone and hypercalcemia. Development of
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parathyroid hormone (PTH) has been described in several case reports ( 52 , 53 ). ICPI-induced hypoparathyroidism differs mechanistically from the other endocrine irAEs. Activating autoantibodies against the calcium-sensing receptor disrupt the glands
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triiodothyronine, thyroxine, free triiodothyronine (FT3), free thyroxine (FT4), ultrasensitive thyroid-stimulating hormone (uTSH), thyroid peroxidase antibody (TPOAb), thyroid antithyroglobulin autoantibody (TgAb) and parathyroid hormone were detected by an
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in both these groups the relationship between bone metastases, primary type/site of NET, laboratory parameters (chromogranin A (CgA), calcium, phosphate, parathyroid hormone (PTH) and vitamin D) and proliferation markers (Ki-67 and mitotic index