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represent a comparably small group of patients in this large cohort that have been studied for decades due to their excellent long-term survival rates and the long life span ahead of them after the end of treatment. Much knowledge about late effects is
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Amsterdam UMC, Emma’s Children’s Hospital, Amsterdam, The Netherlands
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-term survivors suffer from treatment-related late effects, which may occur years to decades after the completion of therapy ( 2 ). Increasing knowledge and recognition of these sequelae resulted in, whenever possible, a reduction or even elimination of
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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primary brain tumours. Individuals with a history of malignant brain tumours of both CO (age ≤ 18 years) and AO (age > 18 years) were invited to participate in the study. Patients were recruited from the adult and childhood late-effects oncology clinics at
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neovasculature ( 4 ), as well as in human prostate cancer cell lines ( 5 , 6 ). Furthermore, studies have demonstrated stimulatory effects of FSH signaling in prostate cancer cell lines ( 7 ). Very recently, FSH was found to promote human prostate cancer cell
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Department of Florey Institute, University of Melbourne, Parkville, Victoria, Australia
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memory, through its receptors in the temporal lobe including the hippocampus ( 26 ). Several studies in women reported reversal of the cognitive effects of reduced androgen levels with E2 add-back therapy (EAT) across varied contexts. In one of the
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and functioning of osteoblasts, and in the osteocyte-osteoclast interaction. It has been shown that the effects of menin can be mediated by several potential mechanisms, such as the interactions with the Runx2 transcription factor, molecules involved
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course. In our study, FDG–PET-guided biopsies of lesions with higher metabolic activity were not performed. The lack of correlation between OS and Ki-67 index may also have been due to the effects of previously administered systemic therapies. Recently
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. Ethics statement This study was authorized by the local ethics committee (Medical Ethics Committee of Zhujiang Hospital of Southern Medical University) (batch no. 2020-KY-047-01) in accordance with the 1964 Declaration of Helsinki and its later