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into later life through recognised epigenetic effects in utero ( 27 , 28 ). Thus, ensuring repletion in all women of childbearing age would help to reduce later health risks, and by reducing later health care costs, should prove to be a cost
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tissues around the body where it has a myriad of different physiological effects. Before we get into the history of vitamin D, let us first remind the reader of the general aspects of its nomenclature, origins and principal functions. Vitamin D is a
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University for Health Sciences, Medical Informatics and Technology (UMIT TIROL), Tirol, Austria
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Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany
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Department of Neurology, Faculty of Medicine, University of Bonn, Bonn, Germany
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a previous cohort study found higher vitamin D levels to be related to greater upper arm strength, but not grip strength ( 13 ), other studies observed positive effects on grip strength, although exclusively in men ( 15 , 17 ), women ( 18 ) and
Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK
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Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK
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importance of cancer treatment late effects and survivorship is being increasingly recognised. Bone toxicity, and more specifically radiotherapy-related insufficiency fractures (RRIFs), are well-established late effects of pelvic radiotherapy, with
Department of Nutrition, Institute of Life Sciences, Federal University of Juiz de Fora, Governador Valadares, Minas Gerais, Brazil
Department of Nutrition, Faculty of Health and Medical Sciences, University of Surrey, University of Surrey, Guildford, UK
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-hydroxyvitamin D, musculoskeletal health, skeletal health, and bone health. We have selected studies investigating the effects of vitamin D on bone health, musculoskeletal markers, osteoporosis, fractures, and falls in otherwise healthy individuals. Vitamin
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effects on the musculoskeletal system, the neuronal system, the immune system, and inflammatory pathways ( 1 , 4 , 34 , 62 , 63 , 64 , 65 , 66 ). FGF23 FGF23 is a member of the endocrine FGF family, along with FGF19 and FGF21 ( 9
School of Nursing, Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK
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circulation include 3epi-25D and sulphated and glucuronide forms of 25D. Intracrine synthesis of 1,25D from 25D in tissues such as the placenta, spleen (immune system) and lungs is associated with immunomodulatory effects. Endocrine synthesis of 1,25D in the
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becomes completely dependent on vitamin D-mediated intestinal absorption of Ca and phosphate to meet the demands of the developing skeleton ( 5 ). Hence, neonatal VDD might lead to hypocalcemia, rickets and impaired bone health in later life ( 6
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Paediatric Neurosciences Research Group, Royal Hospital for Children, NHS Greater Glasgow & Clyde, Glasgow, UK
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was evident in the late teenage years ( Fig. 2 and Table 2 ). However, this sex- dependency was not evident for MFF% and, as a consequence, the RMA also showed the same sex dependency as muscle CSA ( Fig. 2 ). While muscle CSA and RMA also showed a
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Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark
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, 9 , 10 ). The neuropsychiatric effects (e.g. depression and anxiety) of PHPT have been examined using various questionnaires and tests before PTx and up to 10 years later. In 2002, Pasieka et al. found significant alleviation of disease