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Diagnostic criteria and proposed management of immune-related endocrinopathies following immune checkpoint inhibitor therapy for cancer

Ruth Percik

Ruth Percik Institute of Endocrinology, Diabetes and Metabolism, Sheba Medical Centre, Ramat Gan, Israel

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Sherwin Criseno

Sherwin Criseno Department of Endocrinology, University Hospital Birmingham, Birmingham, UK

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Safwaan Adam

Safwaan Adam Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, UK

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Kate Young

Kate Young Royal Marsden Hospital, London, UK

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Daniel L Morganstein

Daniel L Morganstein Department of Endocrinology, Chelsea and Westminster Hospital, London, UK
Royal Marsden Hospital, London, UK

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Terminology Criteria for Adverse Events (CTCAE, currently updated to version V1 for reporting and case management) ( 1 ). In this standardized grading system, symptoms’ severity and need for intervention determine the grading stratification (1 – mild, 5