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Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
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proinflammatory cytokines such as interleukin-6 (IL6), IL12, or IL17 ( 8 , 9 ). Specific chemokines that are also related to the pathogenesis of this disease include C-X-C motif chemokine ligand 9 (CXCL9), CXCL10, CXCL11, and their receptor chemokine receptor
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inflammatory disorder characterized by chronic low-grade inflammation and excessive production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Experimental and clinical evidence suggests that chronic
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, and TNF-α and interleukin-6 (IL-6) concentrations were measured using an ELISA kit (R&D Systems) according to the manufacturer’s instructions. For the in vivo experiment, serum TSH, FT3, and FT4 levels of mice were determined using an ELISA kit
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were related to the JAK-STAT signalling pathway. IL6ST is a member of the interleukin-6 cytokine family, which is capable of forming a complex with IL6 receptor (IL6R) and assists in IL6R activation, thereby initiating signal transduction cascades in
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interleukin (IL)-1α and IL-1β show concentration-dependent negative regulation of NIS ( 16 , 17 ). IL1 is secreted mainly by neutrophils ( 15 ). Previous studies have found that peripheral blood IL-1β decreases in patients with hyperthyroidism. We speculated
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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nimesulide and sodium diclofenac on interleukin-6, interleukin-8, proteoglycans and prostaglandin E2 production by human articular chondrocytes in vitro . Clinical and Experimental Rheumatology 1999 17 151 – 160 . 29 Bifulco M & Ciaglia E . Statin
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regulating the expression of NIS, TPO, TG, and TSH receptors in the thyroid ( 10 , 11 ). Previous studies found that cytokines including TNFα and TNFβ, interferons (IFNα, IFNβ, and IFNγ), interleukins (IL1α, IL1β, and IL6), and TGFβ can also inhibit the mRNA
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in tears from 21 GO patients and 10 healthy controls found that interleukin (IL)-1β, IL-6, and IL-8 levels were significantly higher in those with active GO in relation to patients with inactive GO and healthy controls ( 6 ). Capillary permeability
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in the pro-inflammatory background (interleukin 6 and tumor necrosis factor alpha), insulin resistance, hyperglycemia, dyslipidemia, and altered signaling of thyroid-stimulating hormone, insulin growth factor 1, leptin, adiponectin, and androgens
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Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
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Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
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angiogenic and inflammatory microenvironment of thyroid cancer ( 10 ). Thyroid cancer cells also secrete interleukin 8 for recruitment of neutrophils to tumor sites and formation of an immunosuppressive tumor microenvironment, eventually promoting cancer