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PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
Institut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661/Université Montpellier, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
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Département de Biochimie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHU Montpellier, Montpellier, France
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), insulin-like growth factor (IGF-1), myostatin, follistatin and irisin were evaluated. OC, PINP, CTX and insulin were assayed by Cobas 6000 (Roche Diagnostic). The inter- and intra-assay coefficients of variation (CVs) for the three latter parameters were
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( Fig. 1 ) ( 3 ). The reduced activity of insulin is due to the reduced potential of insulin to stimulate the functioning of various factors of the insulin signaling system, such as tyrosine phosphorylation of the insulin receptor and IRS1 and downstream
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with the endocrine system and induce the secretion of insulin-like growth factor 1 (IGF1), thus promoting bone growth and development ( 53 ). Dysbiosis is an alteration in microbiota composition which can be induced by conditions such as inflammatory
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; IGF-1, insulin-like growth factor 1; iPTH, intact parathyroid hormone; NC, neck circumference; NM, not mentioned; NOS, Newcastle–Ottawa Scale;P, phosphorus; PA, physical activity; PTH, Parathyroid hormone; SDS, standard deviation score; WC, waist