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affecting the SHOX-coding region ( 8 ). Recombinant human growth hormone (rhGH) therapy is already approved for use in patients with SHOX-D in the USA, Europe and other countries ( 9 ), and it seems to have a growth-promoting activity similar to patients
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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hormone therapy; IOS, International Outcome Study; NS, Noonan syndrome. In brief, the ANSWER program® was an observational, multicenter study conducted across 207 USA centers between 2002 and 2016, which monitored the long-term effectiveness and
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Pediatric team of the Clinical Investigation Center 9302/INSERM, Hospital of Children, Toulouse, France
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Patient-Reported Outcomes Unit (PROQOL), UMR 1123, University Paris Cité, INSERM, Paris, France
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insufficiency as part of multiple pituitary hormone deficiencies as well as other conditions (small for gestational age (SGA), Prader–Willi syndrome (PWS), Turner syndrome, or chronic renal failure). Pediatric patients on hormonal replacement therapy for other
Department of Child and Adolescent Medicine, Section of Pediatric Cardiology, University Hospital Jena, Am Klinikum, Jena, Germany
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Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL), University of Leipzig, Liebigstrasse, Leipzig, Germany
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Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL), University of Leipzig, Liebigstrasse, Leipzig, Germany
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treatment and found an increase in EDV and in NT-proBNP levels probably reflecting a modification of cardiac function after commencing growth hormone lowering therapy ( 20 ). Associations between growth hormone status in patients with congenital heart
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evaluation of short stature of undetermined cause . Lancet. Diabetes and Endocrinology 2018 6 564 – 574 . ( https://doi.org/10.1016/S2213-8587(1830034-2 ) 7 Binder G . Short stature due to SHOX deficiency: genotype, phenotype, and therapy . Hormone
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hormone deficiencies (i.e. three or more) plus low serum IGF-I levels (≤2 SDS); (ii) genetic defects affecting the hypothalamic–pituitary axis; or (iii) lesions of the hypothalamic–pituitary area ( 42 ). These patients can continue GH therapy without
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Male Klinefelter syndrome Congenital anorchia/testicular regression Kallmann syndrome Combined pituitary hormone deficiency CNS: Tumors/infiltrative diseases Chemotherapy/Radiation therapy Systemic illness e.g. (inflammatory bowel disease, celiac
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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specific genetic mutations may provide important knowledge on the natural course of the conditions and their development in some cases. It is also important to consider the possible genital response to hormone therapy ( 6 ). Despite this panel of factors
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Department of Endocrinology at Sahlgrenska University Hospital, Gothenburg, Sweden
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, genetics, and therapy of short stature in children: a Growth Hormone Research Society international perspective . Hormone Research in Paediatrics 2019 92 1 – 14 . ( https://doi.org/10.1159/000502231 ) 24 Wit JM Bidlingmaier M de Bruin C Oostdijk
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Internal Medicine, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy
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Istituto Auxologico Italiano, IRCCS, Obesity Unit - Laboratory of Nutrition and Obesity Research, Department of Endocrine and Metabolic Diseases, Milan, Italy
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studies in type 1 diabetes and in healthy subjects. According to mechanistic studies, insulin is one of the main regulators of growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis ( 21 ), frequently involved in growth failure associated with