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Josef Köhrle Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institut für Experimentelle Endokrinologie, Berlin, Germany

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Martina Rauner Department of Medicine III, Universitätsklinikum Dresden, Technische Universität Dresden, Dresden, Germany
Center for Healthy Aging, Universitätsklinikum Dresden, Technische Universität Dresden, Dresden, Germany

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Susan A Lanham-New Department of Nutritional Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

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Endocrine Connections , addresses recent developments and global epidemiological, diagnostic and therapeutic medical issues around vitamin D hormone(s) with an introductory historical perspective on biological functions and measurement of the ‘sun hormone

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Jennifer K Y Ko Department of Obstetrics and Gynecology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China

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Jinghua Shi Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China

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Raymond H W Li Department of Obstetrics and Gynecology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China

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William S B Yeung Department of Obstetrics and Gynecology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China

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Ernest H Y Ng Department of Obstetrics and Gynecology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China

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Introduction Vitamin D is a key hormone in the regulation of calcium and phosphorus metabolism and hence is important for the maintenance of bone health ( 1 ). Its role in human reproduction is suggested by the expression of vitamin D receptor

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Mateo Amaya-Montoya School of Medicine, Universidad de los Andes, Bogotá, Colombia

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Daniela Duarte-Montero School of Medicine, Universidad de los Andes, Bogotá, Colombia

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Luz D Nieves-Barreto School of Medicine, Universidad de los Andes, Bogotá, Colombia

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Angélica Montaño-Rodríguez School of Medicine, Universidad de los Andes, Bogotá, Colombia

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Eddy C Betancourt-Villamizar Team Foods, Bogotá, Colombia

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María P Salazar-Ocampo School of Medicine, Universidad de los Andes, Bogotá, Colombia

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Carlos O Mendivil School of Medicine, Universidad de los Andes, Bogotá, Colombia
Fundación Santa Fe de Bogotá, Section of Endocrinology, Bogotá, Colombia

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integrated hormonal control of calcium plasmatic concentration by modifying bone resorption and intestinal absorption ( 2 ). Both micronutrients are fundamental in various stages of bone metabolism across the lifespan. These include fetal bone mineralization

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Johanna Öberg Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway

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Rolf Jorde Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway

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Yngve Figenschau Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
Diagnostic Clinic, University Hospital of North Norway, Tromso, Norway

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Per Medbøe Thorsby Hormone Laboratory, Department of Medical Biochemistry and Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, Aker, Oslo, Norway

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Sandra Rinne Dahl Hormone Laboratory, Department of Medical Biochemistry and Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, Aker, Oslo, Norway

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Anne Winther Division of Neurosciences, Orthopedics and Rehabilitation Services, University Hospital of North Norway, Tromso, Norway

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Guri Grimnes Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
Division of Internal Medicine, University Hospital of North Norway, Tromso, Norway

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to 25(OH)D measurements ( 15 , 16 ). The aim of this study was therefore to compare 25(OH)D, 1,25(OH) 2 D, 24,25(OH) 2 D, DBP, free 25(OH)D, 1,25(OH) 2 D)/25(OH)D, VMR, parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23), according to

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Jane Fletcher Nutrition Nurses, University Hospitals Birmingham NHS Trust, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, UK
School of Nursing, Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK

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Emma L Bishop Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK

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Stephanie R Harrison Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, UK

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Amelia Swift School of Nursing, Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK

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Sheldon C Cooper Gastroenterology Department, University Hospitals Birmingham NHS Trust, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, UK

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Sarah K Dimeloe Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK

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Karim Raza Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK

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Martin Hewison Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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-hydroxylase), with this activity occurring primarily in the proximal tubules of the kidney under positive and negative control by parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) respectively. Binding to its cognate nuclear vitamin D receptor (VDR

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