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Annalisa Blasetti
Annalisa Blasetti
Department of Paediatrics, University of Chieti, Chieti, Italy
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Valeria Castorani
Valeria Castorani
Department of Paediatrics, University of Chieti, Chieti, Italy
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Nella Polidori
Nella Polidori
Department of Paediatrics, University of Chieti, Chieti, Italy
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Ilaria Mascioli
Ilaria Mascioli
Department of Paediatrics, University of Chieti, Chieti, Italy
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Francesco Chiarelli
Francesco Chiarelli
Department of Paediatrics, University of Chieti, Chieti, Italy
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Cosimo Giannini
Cosimo Giannini
Department of Paediatrics, University of Chieti, Chieti, Italy
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Introduction Type 1 diabetes (T1D) and other chronic diseases are well recognized to adversely affect linear growth in childhood. Indeed, early studies have shown that suboptimal glycemic control and longer disease duration can impair
Wenjun Long
Wenjun Long
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Tuo Zhou
Tuo Zhou
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Xiuping Xuan
Xiuping Xuan
Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
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Qiuli Cao
Qiuli Cao
Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
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Zuojie Luo
Zuojie Luo
Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
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Yingfen Qin
Yingfen Qin
Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
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Qin Ning
Qin Ning
Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Xiaoping Luo
Xiaoping Luo
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Xuemei Xie
Xuemei Xie
Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
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), cardiovascular and cerebrovascular diseases, etc. ( 1 , 2 , 3 ). Intrauterine growth restriction (IUGR), caused by detrimental intrauterine environment, affects 23.8% or approximately 30 million newborns per year globally ( 4 ). In a proper environment, most of
Mohamed Asrih
Mohamed Asrih
Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, Geneva University Hospitals, Geneva, Switzerland
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Flore Sinturel
Flore Sinturel
Thoracic and Endocrine Surgery Division, Department of Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland
Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Richard Dubos
Richard Dubos
Department and Division of Primary Care Medicine, Geneva University Hospitals (HUG), Geneva, Switzerland
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Idris Guessous
Idris Guessous
Department and Division of Primary Care Medicine, Geneva University Hospitals (HUG), Geneva, Switzerland
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Zoltan Pataky
Zoltan Pataky
Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, Geneva University Hospitals, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Charna Dibner
Charna Dibner
Thoracic and Endocrine Surgery Division, Department of Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland
Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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François R Jornayvaz
François R Jornayvaz
Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, Geneva University Hospitals, Geneva, Switzerland
Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Karim Gariani
Karim Gariani
Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, Geneva University Hospitals, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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homeostasis and T2D risk have already been reported ( 5 ), considering sex appears to be of particular importance when searching for biomarkers of metabolic disorders. Growth differentiation factor-15 (GDF15), a member of the transforming growth factor
Giovanni Fanni
Giovanni Fanni
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Petros Katsogiannos
Petros Katsogiannos
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Bipasha Nandi Jui
Bipasha Nandi Jui
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Magnus Sundbom
Magnus Sundbom
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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Susanne Hetty
Susanne Hetty
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Maria J Pereira
Maria J Pereira
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Jan W Eriksson
Jan W Eriksson
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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and pancreatic islets but also of others produced by the pituitary and adrenal glands. Therefore, in this study, we assess growth hormone (GH), ACTH, and cortisol levels, which are largely unexplored in this context. Herein, we report exploratory post
Peter Wolf
Peter Wolf
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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Alexandre Dormoy
Alexandre Dormoy
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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Luigi Maione
Luigi Maione
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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Sylvie Salenave
Sylvie Salenave
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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Jacques Young
Jacques Young
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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Peter Kamenický
Peter Kamenický
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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Philippe Chanson
Philippe Chanson
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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Introduction Acromegaly results in a clinical syndrome following increased serum concentrations of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). If not adequately treated, GH excess is associated with increased morbidity and
Clemens Kamrath
Clemens Kamrath
Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany
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Alexander Eckert
Alexander Eckert
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany
Institute of Epidemiology and Medical Biometry, ZIBMT, Ulm University, Ulm, Germany
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Institute of Epidemiology and Medical Biometry, ZIBMT, Ulm University, Ulm, Germany
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Birgit Rami-Merhar
Birgit Rami-Merhar
Department of Pediatrics and Adolescent Medicine, Medical University Vienna, Vienna, Austria
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Sebastian Kummer
Sebastian Kummer
Department of General Pediatrics, Neonatology and Pediatric Cardiology, Heinrich Heine University, Medical Faculty, Duesseldorf, Germany
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Martin Wabitsch
Martin Wabitsch
Center for Rare Endocrine Diseases, Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Centre, Ulm, Germany
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Katharina Laubner
Katharina Laubner
Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany
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Florian Kopp
Florian Kopp
Forth Clinical Department of Medicine, Academic Teaching Hospital Augsburg, Augsburg, Germany
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Silvia Müther
Silvia Müther
Center for Pediatric Diabetology, DRK-Kliniken-Berlin Westend, Berlin, Germany
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Steffen Mühldorfer
Steffen Mühldorfer
Department for Gastroenterology, Endocrinology and Metabolic Diseases, Bayreuth University Hospital, Friedrich-Alexander University Erlangen-Nuremberg, Bayreuth, Germany
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Reinhard W Holl
Reinhard W Holl
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany
Institute of Epidemiology and Medical Biometry, ZIBMT, Ulm University, Ulm, Germany
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Institute of Epidemiology and Medical Biometry, ZIBMT, Ulm University, Ulm, Germany
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analog of leptin, but none of the other 17 patients with the other LD types ( Table 4 ). One patient documented with RMS was treated with recombinant human insulin-like growth factor 1 (rhIGF1). Table 5 Overview of treatments in patients with
Xianghe Chen
Xianghe Chen
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Xinyu Zeng
Xinyu Zeng
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Xiao Qiu
Xiao Qiu
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Chi Liu
Chi Liu
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Pengcheng Lu
Pengcheng Lu
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Ziming Shen
Ziming Shen
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Xiangxiang Zhou
Xiangxiang Zhou
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Kang Yang
Kang Yang
Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China
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that the diminished expression of Sirt1 would contribute to the higher occurrence of renal interstitial fibrosis in T2DM. That is related to the fact that the downregulation of Sirt1 expression can activate the transforming growth factor β1 (TGF-β1
Xiaohui Qi
Xiaohui Qi
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Ping He
Ping He
Shanghai Hospital Link Center, Shanghai Hospital Development Center, Shanghai, China
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Huayan Yao
Huayan Yao
Computer Net Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Huanhuan Sun
Huanhuan Sun
Wonders Information Co. Ltd, Shanghai, China
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Jiying Qi
Jiying Qi
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Min Cao
Min Cao
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Bin Cui
Bin Cui
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Guang Ning
Guang Ning
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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shown that insulin and insulin-like growth factor (IGF) are involved in the development and progression of malignancies ( 9 , 10 ). Insulin has been reported to be associated with an increased risk of several cancer sites, such as the liver, pancreas
David Q Pham
David Q Pham
Western University of Health Sciences, College of Pharmacy, Pomona, California, USA
Mary & Dick Allen Diabetes Center at Hoag Hospital, Newport Beach, California, USA
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Mary & Dick Allen Diabetes Center at Hoag Hospital, Newport Beach, California, USA
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Ashley Thorsell
Ashley Thorsell
Sansum Diabetes Research Institute, Santa Barbara, California, USA
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Kristin Castorino
Kristin Castorino
Sansum Diabetes Research Institute, Santa Barbara, California, USA
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Brandon Cobb
Brandon Cobb
Sansum Diabetes Research Institute, Santa Barbara, California, USA
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arms of the CONCEPTT? (iii) are there associations between maternal glucose metrics and maternal and neonatal outcomes? (iv) is maternal fear of hypoglycemia a factor in glucose control? (v) What tools are best for assessing neonatal growth and fetal
Svjatoslavs Kistkins
Svjatoslavs Kistkins
Pauls Stradiņš Clinical University Hospital, Riga, Latvia
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Othmar Moser
Othmar Moser
Division of Exercise Physiology and Metabolism, Institute of Sport Science, University of Bayreuth, Bayreuth, Germany
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Vitālijs Ankudovičs
Vitālijs Ankudovičs
Pauls Stradiņš Clinical University Hospital, Riga, Latvia
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Dmitrijs Blizņuks
Dmitrijs Blizņuks
Institute of Smart Computing Technologies, Riga Technical University, Riga, Latvia
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Timurs Mihailovs
Timurs Mihailovs
Institute of Smart Computing Technologies, Riga Technical University, Riga, Latvia
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Sergejs Lobanovs
Sergejs Lobanovs
Pauls Stradiņš Clinical University Hospital, Riga, Latvia
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Harald Sourij
Harald Sourij
Trials Unit for Interdisciplinary Metabolic Medicine, Division of Endocrinology and Diabetolgoy, Medical University of Graz, Graz, Austria
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Andreas F H Pfeiffer
Andreas F H Pfeiffer
Department of Endocrinology and Metabolic Medicine, Campus Benjamin Franklin, Charité University Medicine, Hindenburgdamm, Berlin, Germany
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Valdis Pīrāgs
Valdis Pīrāgs
Pauls Stradiņš Clinical University Hospital, Riga, Latvia
Faculty of Medicine, University of Latvia, Riga, Latvia
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Faculty of Medicine, University of Latvia, Riga, Latvia
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compared to normal weight people with diabetes ( 4 ). With mounting cases of diabesity, especially among geriatric patients, the obesity and diabetes treatment markets are estimated to witness significant growth. The diabesity pandemic is spurred by rapidly
