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Xin He Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Qin Yan Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Chazhen Liu Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Zhengyuan Wang Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Ping Liao Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Tong Liu Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Zehuan Shi Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Qi Song Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Xueying Cui Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Wenjing Wang Laboratory of Functional Medicine, Division of Chronic Non-communicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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Jiajie Zang Department of Nutrition Hygiene, Division of Health Risk Factor Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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response to elevated placental human chorionic gonadotropin (hCG)-stimulating TSH receptors and vary based on geography, ethnicity, BMI, iodine nutritional status, and detection method ( 22 , 23 , 24 ). In 2017, the American Thyroid Association (ATA

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Yanling Cai Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China

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Yan Yang Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China

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Xiao Pang Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China

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Suping Li Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China

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carcinoma, male, testis, sperm, follicle-stimulating hormone, thyroid neoplasm, gonadotropins, luteinizing hormone, testosterone, among others. The search terms were combined with the Boolean operators AND and OR. Inclusion and exclusion criteria for

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Leqi He Department of Clinical Laboratory Medicine, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Xiaoying Li Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Zaoping Chen Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Wei Wang Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Kai Wang Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Xinmei Huang Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Qian Yang Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Wencai Ke Department of Clinical Laboratory Medicine, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Jun Liu Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Bingbing Zha Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China

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Introduction Pregnancy is a unique period of female life when a series of hormone changes jointly regulate thyroid function. Maternal human chorionic gonadotropin (hCG) levels peak at 30,000–100,000 U/L in the eighth to tenth week of gestation

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Ning Yuan Department of Endocrinology, Peking University International Hospital, Beijing, China

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Jianbin Sun Department of Endocrinology, Peking University International Hospital, Beijing, China

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Xin Zhao Department of Endocrinology, Peking University International Hospital, Beijing, China

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Jing Du Department of Endocrinology, Peking University International Hospital, Beijing, China

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Min Nan Department of Endocrinology, Peking University International Hospital, Beijing, China

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Qiaoling Zhang Department of Endocrinology, Peking University International Hospital, Beijing, China

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Xiaomei Zhang Department of Endocrinology, Peking University International Hospital, Beijing, China

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inclusion criteria were as follows: (i) singleton pregnancy, (ii) residency in Beijing for more than 5 years, (iii) 4–8 weeks of gestation as determined using human chorionic gonadotropin (HCG) testing or ultrasonography, and (iv) euthyroidism or SCH (TSH

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Aglaia Kyrilli Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.) - Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Bernard Corvilain Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.) - Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Sofie Bliddal Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Department of Gynecology and Obstetrics, Copenhagen University Hospital (Hvidovre Hospital), Hvidovre, Denmark

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Dorthe Hansen Precht Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Carelink Nærhospital, Roskilde, Denmark

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Ulla Feldt-Rasmussen Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Institute of Clinical Medicine, Faculty of Health and Clinical Research, Copenhagen University, Copenhagen, Denmark

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Kris Poppe Department of Endocrinology, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium
Université Libre de Bruxelles (ULB), Brussels, Belgium

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maternal pregnancy outcomes; in TPOAb+ pregnant women, the thyroidal response to human chorionic gonadotropin stimulation appears to be impaired, and so, these women may fail to meet the pregnancy-related increased demand for thyroid hormone synthesis ( 23

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