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therapies ( 1 ). The remaining treatment options include observation or glucocorticoid therapy and each of them can be used as the primary treatment based on clinical scenario. A recent meta-analysis concluded that patients with milder presentation be
Division of Endocrinology, Mid and South Essex NHS Trust, Broomfield, UK
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adrenocorticotrophic hormone (ACTH) ( 11 ). The LD-SST has an advantage at this early stage of secondary AI, but it may suffer from performance error and resultant false-negative test ( 11 , 12 , 13 ). Glucocorticoids have been the mainstay of treatment of severe
Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China
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Department of Neurosurgery, 900th Hospital, Fuzhou, China
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postoperatively. Preoperative routine examination of the hypothalamus–pituitary–adrenal (HPA) axis and hypothalamus–pituitary–thyroid (HPT) axis functions was performed to determine the low function and the need for oral glucocorticoid and thyroxine replacement
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& Xiong Z . Kidney tissue targeted metabolic profiling of glucocorticoid-induced osteoporosis and the proposed therapeutic effects of rhizoma Drynariae studied using UHPLC/MS/MS . Biomedical Chromatography 2014 28 878 – 884 . ( https://doi.org/10
Department of Emergency Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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Department of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland
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School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
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Department of Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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). Undiagnosed HP following mTBI can have serious physical and psychological consequences depending on which axes are affected ( 20 , 21 ). While untreated glucocorticoid deficiency (GCD) can be life-threatening, symptoms of growth hormone deficiency (GHD) may
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Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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, and dermatitis; and manageable with supportive care ( 43 ). In a prospective study of 174 paediatric low-grade gliomas, only 22 experienced nausea or vomiting requiring anti-emetics during treatment with PBT, and only two required glucocorticoids ( 44
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positive influences ( 16 ), whereas glucocorticoids tend to inhibit GH secretion ( 25 ). Hence, it is important that other pituitary hormone deficiencies are identified and optimally replaced before testing for GHD. Causes of GHD CO-GHD is often