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Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK
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Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK
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excess is defined by 3 or more units of alcohol daily; glucocorticoid use includes current exposure to oral glucocorticoids or previous exposure for more than 3 months at a dose of prednisolone of 5 mg daily or more; current (but not previous) tobacco
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Paediatric Neurosciences Research Group, Royal Hospital for Children, NHS Greater Glasgow & Clyde, Glasgow, UK
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, fracture history, use of oral contraceptives and physical activity. Among the male participants, three had asthma and used glucocorticoid inhaler, and one had eczema that did not require any glucocorticoid therapy. Among the female participants, three had
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://doi.org/10.1210/en.2018-00998 ) 13 Colditz J Thiele S Baschant U Garbe AI Niehrs C Hofbauer LC & Rauner M . Osteogenic Dkk1 mediates glucocorticoid-induced but not arthritis-induced bone loss . Journal of Bone and Mineral Research 2019 34
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
Institut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661/Université Montpellier, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
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Département de Biochimie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHU Montpellier, Montpellier, France
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activities. Neither control subjects nor anorexic patients presented with primary amenorrhoea or were taking any medications that were known to affect bone metabolism, particularly prolonged glucocorticoid use (>3 months) or oestrogen , vitamin K, vitamin D
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receptor inhibitor such as abiraterone will require combined treatment with glucocorticoids, putting bone health even more at risk ( 27 ). Consequently, the prevalence of osteoporosis in patients with nonmetastatic castration-resistant PCa (CRPCa) is as
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-menopausal osteoporosis and/or osteoporosis due to ageing (primary osteoporosis). On the other hand, metabolic conditions such as diabetes mellitus (or prolonged treatments with different drugs such as glucocorticoids) can induce secondary osteoporosis, increasing the