Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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NC Jager KJ . Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease . Nature Reviews: Nephrology 2018 14 151 – 164 . ( https://doi.org/10.1038/nrneph.2017.181 ) 6 Cho MH Jung KJ Jang HS Kim JI Park KM
K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
Department of Medicine, Haukeland University Hospital, Bergen, Norway
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Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway
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K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
Department of Medicine, Haukeland University Hospital, Bergen, Norway
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Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden
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Department of Sleep, Landspitali University Hospital Reykjavík, Reykjavik, Iceland
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Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia
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Albacete Faculty of Medicine, Castilla-La Mancha University, Albacete, Spain
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The National Research Center for the Working Environment, Copenhagen, Denmark
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K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
Department of Medicine, Haukeland University Hospital, Bergen, Norway
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and age at natural menopause: a systematic review and meta-analyses of studies across six continents . International Journal of Epidemiology 2014 43 1542 – 1562 . ( https://doi.org/10.1093/ije/dyu094 ) 8 Zhu D Chung HF Pandeya N Dobson AJ
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Fanconi anemia (FA), dyskeratosis congenita-related telomere biology disorders (DC/TBD), and Diamond–Blackfan anemia (DBA) are inherited bone marrow failure syndromes (IBMFS) with high risks of bone marrow failure, leukemia, and solid tumors. Individuals with FA have reduced fertility. Previously, we showed low levels of anti-Müllerian hormone (AMH), a circulating marker of ovarian reserve, in females with IBMFS. In males, AMH may be a direct marker of Sertoli cell function and an indirect marker of spermatogenesis. In this study, we assessed serum AMH levels in pubertal and postpubertal males with FA, DC/TBD, or DBA and compared this with their unaffected male relatives and unrelated healthy male volunteers. Males with FA had significantly lower levels of AMH (median: 5 ng/mL, range: 1.18–6.75) compared with unaffected male relatives (median: 7.31 ng/mL, range: 3.46–18.82, P = 0.03) or healthy male volunteers (median: 7.66 ng/mL, range: 3.3–14.67, P = 0.008). Males with DC/TBD had lower levels of AMH (median: 3.76 ng/mL, range: 0–8.9) compared with unaffected relatives (median: 5.31 ng/mL, range: 1.2–17.77, P = 0.01) or healthy volunteers (median: 5.995 ng/mL, range: 1.57–14.67, P < 0.001). Males with DBA had similar levels of AMH (median: 3.46 ng/mL, range: 2.32–11.85) as unaffected relatives (median: 4.66 ng/mL, range: 0.09–13.51, P = 0.56) and healthy volunteers (median: 5.81 ng/mL, range: 1.57–14.67, P = 0.10). Our findings suggest a defect in the production of AMH in postpubertal males with FA and DC/TBD, similar to that observed in females. These findings warrant confirmation in larger prospective studies.
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Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Besides age, estrogen exposure plays a crucial role in changes in bone density (BD) in women. Premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS) are conditions in reproductive-aged women in which the exposure to estrogen is substantially different. Women with a history of preeclampsia (PE) are expected to have normal estrogen exposure. Within the CREw-IMAGO study, we investigated if trabecular BD is different in these women because of differences in the duration of estrogen exposure. Trabecular BD was measured in thoracic vertebrae on coronary CT scans. Women with a reduced estrogen exposure (POI) have a lower BD compared to women with an intermediate exposure (PE) (mean difference (MD) −26.8, 95% CI −37.2 to −16.3). Women with a prolonged estrogen exposure (PCOS) have the highest BD (MD 15.0, 95% CI 4.3–25.7). These results support the hypothesis that the duration of estrogen exposure in these women is associated with trabecular BD.
Significance statement
Our results suggest that middle-aged women with PCOS have a higher BD and women with POI have a lower BD. We hypothesized that this is due to either a prolonged estrogen exposure, as seen in women with PCOS, or a reduced estrogen exposure, as in women with POI. In the counseling of women with reproductive disorders on long-term health issues, coronary CT provides a unique opportunity to assess both coronary artery calcium score for cardiovascular screening as well as trabecular BD.
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Clinical Genetics and Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
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Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark
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Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark
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recent years, especially concerning the natural course during adulthood. Knowledge concerning 47,XYY syndrome is much more limited. Here, we review the similarities and differences between KS and XYY. Diagnosis and epidemiology of male supernumerary
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2014 14 123 . ( https://doi.org/10.1186/1472-6874-14-123 ) 11 Ozkan S Murk W & Arici A . Endometriosis and infertility: epidemiology and evidence-based treatments . Annals of the New York Academy of Sciences 2008 1127 92 – 100 . ( https
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methods General information The STROBE (Strengthening the Reporting of Observational studies in Epidemiology) Guidelines were followed for reporting the study ( 5 ). This study is part of a larger project aimed at analyzing selected indicators of the
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CUNY Graduate School of Public Health and Health Policy, New York, New York, USA
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Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
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. Limitations of direct immunoassays for measuring circulating estradiol levels in postmenopausal women and men in epidemiologic studies . Cancer Epidemiology, Biomarkers and Prevention 2010 19 903 – 906 . ( https://doi.org/10.1158/1055-9965.EPI-10
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review of adolescent gender dysphoria literature: 1) epidemiology . PLoS Global Public Health 2022 2 e0000245. ( https://doi.org/10.1371/journal.pgph.0000245 ) 9 Association American Psychiatry . Diagnostic and Statistical Manual of Mental Disorders
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1244 – 1255 . ( https://doi.org/10.1097/GME.0000000000001226 ) 10 Canavan C West J Card T . The epidemiology of irritable bowel syndrome . Clinical Epidemiology 2014 6 71 – 80 . ( https://doi.org/10.2147/CLEP
