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Functional hypogonadism in adolescence: an overlooked cause of secondary hypogonadism

Rebeca Esquivel-Zuniga

Rebeca Esquivel-Zuniga Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA

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Alan D Rogol

Alan D Rogol Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA

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psychosocial ones, can affect the timing and tempo of pubertal maturation. The pro-inflammatory cytokines, especially tumor necrosis factor α, interleukin 1β (IL), and IL-6 are prominent and may act directly at the growth plate ( 58 ). Immunomodulatory drugs