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the biological clock oscillators, the pineal gland secretes melatonin into the blood with high level during the subjective night and low level during the subjective day ( 2 ) and is a typical model system for the study of circadian rhythm. Melatonin
Division of Endocrinology, Division of Nephrology, Endocrine Research Laboratory, Department of Medicine
Division of Endocrinology, Division of Nephrology, Endocrine Research Laboratory, Department of Medicine
Division of Endocrinology, Division of Nephrology, Endocrine Research Laboratory, Department of Medicine
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are significant similarities between the morbidity of Cushing's syndrome and renal failure (8, 9) . Thus, it is important to be able to properly assess the HPA axis in ESRD subjects. The current study was designed to evaluate the circadian rhythm of
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Metabolism 1968 28 1014 – 1022 . ( doi:10.1210/jcem-28-7-1014 ). 15 Kem DC Weinberger MH Gomez-Sanchez C Kramer NJ Lerman R Furuyama S Nugent CA . Circadian rhythm of plasma aldosterone concentration in patients with primary aldosteronism
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Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark
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Department of Clinical Biochemistry (KB3014), Department of Technology, Department of Clinical Biochemistry, Department of Biomedical Sciences, Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark
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regulation of energy metabolism . Nature Reviews. Endocrinology 2014 10 157 – 163 . ( doi:10.1038/nrendo.2013.234 ). 8 Bray MS Young ME . Circadian rhythms in the development of obesity: potential role for the circadian
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observed in control mice ( 57 ). This change in the circadian rhythm of feeding correlated with similar changes in physical activity and energy expenditure. These results suggested a critical role for Kiss1 ARC neurons in the regulation of circadian
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innervation of the adrenals and a local circadian clock within the adrenal glands. Apart from measurable rhythms in cortisol, GR activity is influenced by its own rhythm. CLOCK influences acetyl-transferase activity, which is directly capable of acetylating
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administered in two or three divided doses (the higher in the morning), as suggested in recent Consensus and Guidelines ( 2 , 6 ). Nevertheless, none of the proposed regimen is currently able to replicate the physiological cortisol circadian rhythm
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Department of Clinical Biochemistry, Imperial College Healthcare NHS Trust, London, UK
Department of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
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Department of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
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profile with oral medication is a significant challenge because normal cortisol production is pulsatile and consists of a circadian rhythm and an ultradian rhythm ( 3 , 4 , 5 ). Under-replacement may cause lethargy and an increased risk of Addisonian
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patients take prednisolone as early as possible upon wakening. Other studies are trialling glucocorticoid pump replacement therapy to mimic circadian rhythms; however, there is limited evidence for their use so far ( 24 , 25 ). The importance of pulsatile
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months ( 11 ). At the end of the 3 months, dual-release hydrocortisone mimicked the physiological circadian rhythm of cortisol secretion, confirming the results these authors had previously published in a phase 1 study ( 9 ). Moreover, the authors also