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Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
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Diabetes, Endocrinology and Metabolism Centre, Manchester University NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester, UK
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Oxford Liver Unit, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, UK
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NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
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NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
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shifts. This challenges the alignment between internal circadian time, and the external light–darkness environment, and potentially mediates some of the disease associations seen with shift work. Pathological accumulation of fat in the liver drives non
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Introduction Many aspects of endocrinology and metabolism exhibit 24-h rhythms that are driven by an endogenous circadian timing system ( 1 , 2 , 3 ). This circadian system is comprised of a central light-entrained clock in the
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University Clinic of Medicine, Cantonal Hospital Baselland, Liestal, Switzerland
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Introduction The hypothalamopituitary–adrenal (HPA) axis tightly regulates cortisol secretion ( 1 ). Cortisol is secreted in a circadian rhythm with a brisk increase upon awakening and a nadir around midnight ( 1 ). Food is an external factor
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, 17 , 20 ). The model diversity illustrated this phenomenon. It is, however, reassuring that the main model structure of the final model was similar to other published models ( 16 ), with the main differences being the lack of circadian rhythm ( 16
School of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China
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Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, Ningxia, China
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Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, Ningxia, China
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Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, Ningxia, China
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. Nutrients 2022 14 914 . ( https://doi.org/10.3390/nu14040914 ) 11 Acosta-Rodríguez VA Rijo-Ferreira F Green CB & Takahashi JS . Importance of circadian timing for aging and longevity . Nature Communications 2021 12 2862 . ( https://doi.org/10
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Christiansen C . Mechanism of circadian variation in bone resorption . Bone 2002 30 307 – 313 . ( https://doi.org/10.1016/s8756-3282(0100662-7 ) 36 Bunck MC Poelma M Eekhoff EM Schweizer A Heine RJ Nijpels G Foley JE Diamant M . Effects
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-regulation in nonalcoholic fatty liver disease . Biochimica et Biophysica Acta 2013 1831 803 – 818 . ( https://doi.org/10.1016/j.bbalip.2012.12.014 ) 27 Liu Y Zhang Y Yin J Ruan Z Wu X & Yin Y . Uridine dynamic administration affects circadian
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:1 circadian ratio. All animal experiments were approved by the Institutional Animal Care and Use Committee of Yangzhou University. The code is No. YZU-TYXY-31. After 1 week of adaptive feeding, the mice were randomly divided into normal group (ZC, n = 12