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Valeria Hirschler
Valeria Hirschler
University of Buenos Aires, Buenos Aires, Argentina
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Claudia Molinari
Claudia Molinari
University of Buenos Aires, Buenos Aires, Argentina
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Silvia Lapertosa
Silvia Lapertosa
UNNE, Corrientes, Argentina
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Gustavo Maccallini
Gustavo Maccallini
Hidalgo Laboratories, Buenos Aires, Argentina
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Claudio D Gonzalez
Claudio D Gonzalez
CEMIC, Buenos Aires, Argentina
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central OB vs OW/OB with central OB; (g) all categories are significantly dif ferent. BP, blood pressure; OB, obesity; OW, overweight; TG, triglycerides; z-BMI, BMI z-score. Multivariate associations Multiple linear regression analyses
Mei Li
Mei Li
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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Yanfei Chen
Yanfei Chen
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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Binrong Liao
Binrong Liao
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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Jing Tang
Jing Tang
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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Jingzi Zhong
Jingzi Zhong
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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Dan Lan
Dan Lan
Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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exhibit sexual dimorphism in adults, are increased in obese prepubertal girls and do not suffer modifications in girls with idiopathic central precocious puberty . Peptides 2011 32 1781 – 1786 . ( https://doi.org/10.1016/j.peptides.2011.07.016 ) 27 Zhou
Teodoro Durá-Travé
Teodoro Durá-Travé
Department of Pediatrics, School of Medicine, University of Navarra, Pamplona, Spain
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
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Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
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Fidel Gallinas-Victoriano
Fidel Gallinas-Victoriano
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
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María Malumbres-Chacon
María Malumbres-Chacon
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
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Lotfi Ahmed-Mohamed
Lotfi Ahmed-Mohamed
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
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María Jesús Chueca -Guindulain
María Jesús Chueca -Guindulain
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
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Navarra Institute for Health Research (IdisNA), Pamplona, Spain
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Sara Berrade-Zubiri
Sara Berrade-Zubiri
Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
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Navarra Institute for Health Research (IdisNA), Pamplona, Spain
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Introduction Central precocious puberty (CPP) is defined as the premature activation of the hypothalamic–pituitary–gonadal axis (HPG) with the onset of breast development before 8 years of age in girls and an increase in testicular size in
Valentina Guarnotta
Valentina Guarnotta
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy
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Silvia Lucchese
Silvia Lucchese
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy
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Mariagrazia Irene Mineo
Mariagrazia Irene Mineo
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy
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Donatella Mangione
Donatella Mangione
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Ostetricia e Ginecologia, Università di Palermo, Palermo, Italy
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Renato Venezia
Renato Venezia
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Ostetricia e Ginecologia, Università di Palermo, Palermo, Italy
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Piero Luigi Almasio
Piero Luigi Almasio
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Gastroenterologia ed Epatologia, Università di Palermo, Palermo, Italy
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Carla Giordano
Carla Giordano
Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza ‘G. D’Alessandro’ (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Palermo, Italy
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, as in PCOS, PP girls were excessively insulin-resistant from mid-childhood through puberty. This was associated with central adiposity and dyslipidemia but not obesity ( 34 ). In agreement with these authors, other studies documented that PP patients
Min Yang
Min Yang
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Xiangling Deng
Xiangling Deng
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Shunan Wang
Shunan Wang
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Bo Zhou
Bo Zhou
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Wenquan Niu
Wenquan Niu
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China
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Zhixin Zhang
Zhixin Zhang
International Medical Services, China-Japan Friendship Hospital, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
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calculated as measured weight divided by height squared (kg/m 2 ). BMI category was defined as obesity, overweight and non-overweight or obesity according to the China criteria (2009) ( 22 ). Time spent on outdoor activities every day was calculated as the
Britt J van Keulen
Britt J van Keulen
Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Endocrinology, Amsterdam, The Netherlands
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Conor V Dolan
Conor V Dolan
Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Bibian van der Voorn
Bibian van der Voorn
Department of Pediatric Endocrinology, Sophia Kinderziekenhuis, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Ruth Andrew
Ruth Andrew
Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK
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Brian R Walker
Brian R Walker
Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK
Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
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Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
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Hilleke Hulshoff Pol
Hilleke Hulshoff Pol
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
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Dorret I Boomsma
Dorret I Boomsma
Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Joost Rotteveel
Joost Rotteveel
Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Endocrinology, Amsterdam, The Netherlands
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Martijn J J Finken
Martijn J J Finken
Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Endocrinology, Amsterdam, The Netherlands
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E1022 – E1030. ( https://doi.org/10.1210/jc.2013-1173 ) 53 Kumari M Chandola T Brunner E Kivimaki M . A nonlinear relationship of generalized and central obesity with diurnal cortisol secretion in the Whitehall II study. Journal of
Enora Le Roux
Enora Le Roux
Université de Paris, ECEVE UMR 1123, Inserm, Paris, France
AP-HP.Nord-Université de Paris, Hôpital Universitaire Robert Debré, Unité d’Épidémiologie Clinique, Inserm, Paris, France
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AP-HP.Nord-Université de Paris, Hôpital Universitaire Robert Debré, Unité d’Épidémiologie Clinique, Inserm, Paris, France
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Florence Menesguen
Florence Menesguen
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service d’Endocrinologie et Médecine de la Reproduction, Centre de Maladies Endocriniennes Rares de la Croissance et du Développement, Centre de Pathologies Gynécologiques Rares, Paris, France
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Isabelle Tejedor
Isabelle Tejedor
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service d’Endocrinologie et Médecine de la Reproduction, Centre de Maladies Endocriniennes Rares de la Croissance et du Développement, Centre de Pathologies Gynécologiques Rares, Paris, France
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Marc Popelier
Marc Popelier
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service de Diabétologie, Paris, France
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Marine Halbron
Marine Halbron
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service de Diabétologie, Paris, France
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Pauline Faucher
Pauline Faucher
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service de Nutrition, Centre du Syndrome de Prader-Willi et Autres Obésités Rares, Paris, France
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Sabine Malivoir
Sabine Malivoir
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service d’Endocrinologie et Médecine de la Reproduction, Centre de Maladies Endocriniennes Rares de la Croissance et du Développement, Centre de Pathologies Gynécologiques Rares, Paris, France
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Graziella Pinto
Graziella Pinto
AP-HP.Université de Paris Centre, Hôpital Universitaire Necker Enfants Malades, Département d’Endocrinologie, Diabétologie et Gynécologie Pédiatrique, Paris, France; Centre de Maladies Endocriniennes Rares de la Croissance et du Développement, Centre de Pathologies Gynécologiques Rares, Paris, France
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Juliane Léger
Juliane Léger
AP-HP.Nord-Université de Paris, Hôpital Universitaire Robert Debré, Service d’Endocrinologie Diabétologie Pédiatrique, Centre de Référence des Maladies Endocriniennes de la Croissance et du Développement, Paris, France
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Stephane Hatem
Stephane Hatem
Institute of Cardiology and Nutrition, Paris, France
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Michel Polak
Michel Polak
AP-HP.Université de Paris Centre, Hôpital Universitaire Necker Enfants Malades, Département d’Endocrinologie, Diabétologie et Gynécologie Pédiatrique, Paris, France; Centre de Maladies Endocriniennes Rares de la Croissance et du Développement, Centre de Pathologies Gynécologiques Rares, Paris, France
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Christine Poitou
Christine Poitou
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service de Nutrition, Centre du Syndrome de Prader-Willi et Autres Obésités Rares, Paris, France
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Philippe Touraine
Philippe Touraine
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service d’Endocrinologie et Médecine de la Reproduction, Centre de Maladies Endocriniennes Rares de la Croissance et du Développement, Centre de Pathologies Gynécologiques Rares, Paris, France
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TRANSEND programme as a dedicated care pathway for patients in transition, where a case manager has a central role in adapting and coordinating for each patient, from their discharge from paediatric services to their strong attachment in adult services
Heike Hoyer-Kuhn
Heike Hoyer-Kuhn
Department of Paediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
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Angela Huebner
Angela Huebner
Department of Paediatrics, University Children’s Hospital Dresden, Dresden, Germany
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Anette Richter-Unruh
Anette Richter-Unruh
University Children’s Hospital Bochum, Bochum, Nordrhein-Westfalen, Germany
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Markus Bettendorf
Markus Bettendorf
University Children’s Hospital Heidelberg, Heidelberg, Germany
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Tilman Rohrer
Tilman Rohrer
University Children’s Hospital Homburg, Homburg, Germany
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Klaus Kapelari
Klaus Kapelari
University Children’s Hospital Innsbruck, Innsbruck, Austria
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Stefan Riedl
Stefan Riedl
Department of Pediatric, Medical University of Vienna, Vienna, Austria
St.Anna Kinderspital, Medical University of Vienna, Vienna, Austria
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St.Anna Kinderspital, Medical University of Vienna, Vienna, Austria
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Klaus Mohnike
Klaus Mohnike
Department of Biometrics, Otto von Guericke Universität Magdeburg, Magdeburg, Sachsen-Anhalt, Germany
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Helmuth-Günther Dörr
Helmuth-Günther Dörr
University Children’s Hospital Erlangen, Erlangen, Germany
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Friedrich-Wilhelm Roehl
Friedrich-Wilhelm Roehl
Department of Biometrics, Otto von Guericke Universität Magdeburg, Magdeburg, Sachsen-Anhalt, Germany
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Katharina Fink
Katharina Fink
Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany
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Reinhard W Holl
Reinhard W Holl
Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany
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Joachim Woelfle
Joachim Woelfle
University Children’s Hospital Erlangen, Erlangen, Germany
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treated in a big/small center. A custom-made electronic health record software is used at the participating centers for standardized documentation. Pseudonymized data are transferred for central analysis, including a validation step and a benchmarking
