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Division of Epidemiology and Biometry, Carl von Ossietzky Universität, Oldenburg, Germany
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KRANIOPHARYNGEOM Registry 2019, 36 out of 60 (60%) of the included patients were classified with hypothalamic syndrome ( 6 ). Obesity was present in 35% ( n = 21) of these patients ( 6 ). Hypothalamic syndrome is also characterized by abnormal eating behavior such
National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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significant difference between groups 1–3 in terms of rapid-onset obesity, central hypoventilation, and hypothalamic dysfunction. The incidence of abnormal emotion, cognition, and behavior was not reported in group 1, but it was lower in group 2 compared to
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Institute of Mathematics, Leiden University, Leiden, The Netherlands
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Division of Pediatric Oncology, University Medical Centre Groningen, Groningen, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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, 2 , 3 , 4 , 5 ). Due to the fact that the hypothalamus plays an essential role in endocrine balance, nutritional habits, and body composition, HD may lead to hypothalamic obesity (HO) ( 5 , 6 ). In children with acquired brain damage, however
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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Fernandois D Velasco I Rodriguez-Vazquez E Roa J Vazquez MJ Ruiz-Pino F Rubio M Pineda R Central ceramide signaling mediates obesity-induced precocious puberty . Cell Metabolism 2020 32 951 .e8 – 966.e8 . ( https://doi.org/10.1016/j.cmet.2020
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Hunan Key Laboratory of Organ Fibrosis, Central South University, Changsha, Hunan, China
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Hunan Key Laboratory of Organ Fibrosis, Central South University, Changsha, Hunan, China
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gastrointestinal movement, induces gastric acid release, and produces antidepressants and other effects ( 4 ). In humans and rodents, plasma ghrelin increases during fasting and decreases during obesity. Plasma ghrelin levels also change dynamically under the
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Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Endo-ERN European Reference Network on Rare endocrine conditions
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Endo-ERN European Reference Network on Rare endocrine conditions
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Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
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Introduction The hypothalamus is a key organ centrally located in the brain, linking the endocrine and the nervous systems, thereby being responsible for the homeostasis of the body. Impaired function of the hypothalamus, described as
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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), resulting in pituitary insufficiency, decreased energy expenditure, overweight and obesity, disturbed day–night rhythm, loss of initiative, hyperphagia, and behavioral problems ( 14 ). Overweight and obesity are well-known risk factors for impaired bone
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children ( 11 ). Another caveat in interpreting the results of GH stimulation tests is that adult GHD itself is complicated by an increased susceptibility to central obesity. Obesity per se is a state of relative GHD ( 151 , 152 , 153 , 154 ), and
Division of Epidemiology and Biometry, Carl von Ossietzky University, Oldenburg, Germany
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Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland
Department of Pediatrics, McMaster Children’s Hospital and McMaster University, Hamilton, Ontario, Canada
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patients with hypothalamic involvement (HI) and/or treatment-related hypothalamic lesion (HL), the body mass index (BMI) increases during the first year after surgery, frequently resulting in morbid obesity ( 11 , 12 , 13 , 14 , 15 ). Severe obesity
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). GH also has a protective effect on the central nervous system, with beneficial effects of GH therapy reported in patients with spinal cord injury. Accordingly in animal models GH appears to stimulate neurogenesis ( 1 , 2 , 3 ). However, brain