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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Institute of Mathematics, Leiden University, Leiden, The Netherlands
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Division of Pediatric Oncology, University Medical Centre Groningen, Groningen, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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sensation, and pituitary regulation ( 5 ). In children with HD, hyperphagia was long thought to be the major cause of HO. However, hyperphagia is not present in all children with HO, and recent studies suggest that hyperphagia is significant risk factor
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S . Effects of adult growth hormone deficiency and replacement therapy on the cardiometabolic risk profile . Pituitary 2022 25 211 – 228 . ( https://doi.org/10.1007/s11102-022-01207-1 ) 7 Ho KK & 2007 GH Deficiency Consensus Workshop
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secondary deficiency of IGF-1 ( 1 ). Several studies have shown that congenital GHD is associated with an increased risk of metabolic syndromes, such as nonalcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hyperlipidemia ( 4