Margarida Brito
Margarida Brito
Department of Medical Oncology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal
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Susana Prazeres
Susana Prazeres
Department of Clinical Pathology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal
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Marta Malheiros
Marta Malheiros
Department of Clinical Pathology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal
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Introduction Fulvestrant was the first selective estrogen receptor degrader (SERD) ( 1 ) to enter clinical practice and represents, alone or in combination with targeted therapies, a key compound for endocrine advanced breast cancer (ABC). As
Enrique Pedernera
Enrique Pedernera
Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México
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Flavia Morales-Vásquez
Flavia Morales-Vásquez
Instituto Nacional de Cancerología, Ciudad de México, México
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María J Gómora
María J Gómora
Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México
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Miguel A Almaraz
Miguel A Almaraz
Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México
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Esteban Mena
Esteban Mena
Universidad Nacional Autónoma de México, Facultad de Medicina, Secretaría General, Ciudad de México, México
Universidad La Salle, Posgrado de la Facultad de Ciencias Químicas, Ciudad de México, México
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Universidad La Salle, Posgrado de la Facultad de Ciencias Químicas, Ciudad de México, México
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Delia Pérez-Montiel
Delia Pérez-Montiel
Instituto Nacional de Cancerología, Ciudad de México, México
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Elizabeth Rendon
Elizabeth Rendon
Hospital Militar de Especialidades de la Mujer y Neonatología. Ciudad de México, México
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Horacio López-Basave
Horacio López-Basave
Instituto Nacional de Cancerología, Ciudad de México, México
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Juan Maldonado-Cubas
Juan Maldonado-Cubas
Universidad La Salle, Posgrado de la Facultad de Ciencias Químicas, Ciudad de México, México
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Carmen Méndez
Carmen Méndez
Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Embriología y Genética, Ciudad de México, México
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expression profile in each type of ovarian tumor ( 4 ). Evidence proves the expression of enzymes in several types of tumors involved in the metabolism of steroid hormones. Moreover, their presence in breast and prostate cancer has been extensively explored
Vita Birzniece
Vita Birzniece
School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Garvan Institute of Medical Research, New South Wales, Australia
School of Medical Sciences, University of New South Wales, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Garvan Institute of Medical Research, New South Wales, Australia
School of Medical Sciences, University of New South Wales, New South Wales, Australia
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Teresa Lam
Teresa Lam
School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, New South Wales, Australia
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Mark McLean
Mark McLean
School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Navneeta Reddy
Navneeta Reddy
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Haleh Shahidipour
Haleh Shahidipour
School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Amy Hayden
Amy Hayden
School of Medicine, Western Sydney University, New South Wales, Australia
Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia
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Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia
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Howard Gurney
Howard Gurney
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia
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Glenn Stone
Glenn Stone
School of Computing, Engineering and Mathematics, Western Sydney University, New South Wales, Australia
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Rikke Hjortebjerg
Rikke Hjortebjerg
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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Jan Frystyk
Jan Frystyk
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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vitro studies in other cancer types have demonstrated high levels of IGFBP-3 in cancer cells, with IGFBP-3 stimulating breast cancer growth and being a poor prognostic marker for breast cancer patients ( 67 , 68 , 69 , 70 ). Thus, it is difficult to
Matteo Scopel
Matteo Scopel
Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy
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Eugenio De Carlo
Eugenio De Carlo
Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy
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Francesca Bergamo
Francesca Bergamo
Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy
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Sabina Murgioni
Sabina Murgioni
Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy
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Riccardo Carandina
Riccardo Carandina
Radiodiagnostic Unit, University Hospital of Padua, Padua, Italy
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Anna Rita Cervino
Anna Rita Cervino
Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy
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Marta Burei
Marta Burei
Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy
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Federica Vianello
Federica Vianello
Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy
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Vittorina Zagonel
Vittorina Zagonel
Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy
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Matteo Fassan
Matteo Fassan
Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Roberto Vettor
Roberto Vettor
Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy
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complications such as liver metastases, specific endocrine syndromes or gastrointestinal and/or respiratory occlusive symptoms. Bone involvement is hardly ever studied in specific follow-ups. The difference compared to other cancers (e.g. breast, bladder or
Mark J C van Treijen
Mark J C van Treijen
Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
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Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
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Catharina M Korse
Catharina M Korse
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Clinical Chemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Department of Clinical Chemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Wieke H Verbeek
Wieke H Verbeek
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Gastroenterology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Department of Gastroenterology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Margot E T Tesselaar
Margot E T Tesselaar
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Gerlof D Valk
Gerlof D Valk
Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
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Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
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in these neoplastic processes, making these tumors more vulnerable to treatment. In other malignancies, like breast cancer, gene expression signatures derived from tumor tissue already guide individualization of treatment and have proven valuable ( 35
Arnaud Lagarde
Arnaud Lagarde
Aix Marseille Univ, APHM, INSERM, MMG, Laboratory of Molecular Biology Hospital La Conception, Marseille, France
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Grégory Mougel
Grégory Mougel
Aix Marseille Univ, APHM, INSERM, MMG, Laboratory of Molecular Biology Hospital La Conception, Marseille, France
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Lucie Coppin
Lucie Coppin
Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 – CANTHER – Cancer – Heterogeneity Plasticity and Resistance to Therapies, Lille, France
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Magalie Haissaguerre
Magalie Haissaguerre
Service d’Endocrinologie, Centre Hospitalier Universitaire, Hôpital du Haut Levêque, Pessac, France
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Lauriane Le Collen
Lauriane Le Collen
Endocrinology, Diabetology and Nutrition Unit, University Hospital of Reims, Reims, France
Inserm/CNRS UMR 1283/8199, Pasteur Institute of Lille, EGID, Lille, France
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Inserm/CNRS UMR 1283/8199, Pasteur Institute of Lille, EGID, Lille, France
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Amira Mohamed
Amira Mohamed
Laboratory of Molecular Biology, Hospital La Conception, APHM, Marseille, France
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Marc Klein
Marc Klein
Service Endocrinologie, CHU de Nancy, Hôpital de Brabois, Vandoeuvre-lès-Nancy, France
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Marie-Françoise Odou
Marie-Françoise Odou
CHU Lille, Service de Biochimie et Biologie Moléculaire ‘Hormonologie, Métabolisme-Nutrition, Oncologie’, Lille, France
Univ. Lille, Inserm, CHU Lille, U1286 – Infinite – Institute for Translational Research in Inflammation, Lille, France
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Univ. Lille, Inserm, CHU Lille, U1286 – Infinite – Institute for Translational Research in Inflammation, Lille, France
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Antoine Tabarin
Antoine Tabarin
Service d’Endocrinologie, Centre Hospitalier Universitaire, Hôpital du Haut Levêque, Pessac, France
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Hedia Brixi
Hedia Brixi
Department of Gastroenterology and Digestive Oncology, Reims University Hospital, Reims, France
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Thomas Cuny
Thomas Cuny
Aix Marseille Univ, APHM, INSERM, MMG, Department of Endocrinology, Hospital La Conception, Marseille, France
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Brigitte Delemer
Brigitte Delemer
Endocrinology, Diabetology and Nutrition Unit, University Hospital of Reims, Reims, France
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Anne Barlier
Anne Barlier
Aix Marseille Univ, APHM, INSERM, MMG, Laboratory of Molecular Biology Hospital La Conception, Marseille, France
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Pauline Romanet
Pauline Romanet
Aix Marseille Univ, APHM, INSERM, MMG, Laboratory of Molecular Biology Hospital La Conception, Marseille, France
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mutation as a cause of early-onset breast cancer . Familial Cancer 2020 19 307 – 310 . ( https://doi.org/10.1007/s10689-020-00186-1 ) 10 Trubicka J Filipek I Iwanowski P Rydzanicz M Grajkowska W Piekutowska-Abramczuk D Chrzanowska K
Orwa Dandash
Orwa Dandash
Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
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James Allebone
James Allebone
Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
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Adam Mirabelli
Adam Mirabelli
Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
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Nicholas Russell
Nicholas Russell
Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
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Mathis Grossmann
Mathis Grossmann
Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
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Andrea Gogos
Andrea Gogos
Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia
Department of Florey Institute, University of Melbourne, Parkville, Victoria, Australia
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Department of Florey Institute, University of Melbourne, Parkville, Victoria, Australia
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Richard A Kanaan
Richard A Kanaan
Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
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venous thromboembolism (VTE); breast cancer; systolic blood pressure >160 or diastolic blood pressure >100; New York Heart Association class 3 or 4 angina or heart failure; stroke, transient ischemic attack, myocardial infarction, or angina within 12
