Brendan J Nolan
Brendan J Nolan
Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia
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Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia
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Aviva S Frydman
Aviva S Frydman
Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
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Shalem Y Leemaqz
Shalem Y Leemaqz
College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia
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Meg Carroll
Meg Carroll
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia
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Mathis Grossmann
Mathis Grossmann
Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia
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Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia
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Jeffrey D Zajac
Jeffrey D Zajac
Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia
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Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia
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Ada S Cheung
Ada S Cheung
Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia
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Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia
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more rapid feminisation with greater testosterone suppression and enhanced breast development ( 2 ), however, others raise concerns regarding breast cancer and cardiovascular disease risk with the use of progestins ( 3 ). Due to a lack of evidence
Xiaomin Li
Xiaomin Li
Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu, China
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Ling Fang
Ling Fang
Department of Breast Surgery, Cheng Du Shang Jin Nan Fu Hospital, West China Hospital, Sichuan University, Chengdu, China
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Hongjiang Li
Hongjiang Li
Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu, China
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Xiaoqin Yang
Xiaoqin Yang
Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu, China
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Introduction Breast cancer is a malignant tumor that occurs in the mammary gland. It is the leading female malignant tumor, posing a major threat to women’s health globally. However, the incidence of breast cancer worldwide, including China
Martin Zweifel
Martin Zweifel
Department of Medical Oncology, University Hospital Bern, Bern, Switzerland
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Beat Thürlimann
Beat Thürlimann
Breast Centre St. Gallen, Kantonsspital St. Gallen, St. Gallen, Switzerland
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Salome Riniker
Salome Riniker
Breast Centre St. Gallen, Kantonsspital St. Gallen, St. Gallen, Switzerland
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Patrik Weder
Patrik Weder
Breast Centre St. Gallen, Kantonsspital St. Gallen, St. Gallen, Switzerland
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Roger von Moos
Roger von Moos
Kantonsspital Graubünden, Chur, Switzerland
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Olivia Pagani
Olivia Pagani
Istituto Oncologico della Svizzera Italiana, Bellinzona, Switzerland
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Martin Bigler
Martin Bigler
SAKK Coordinating Centre, Bern, Switzerland
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Karin M Rothgiesser
Karin M Rothgiesser
SAKK Coordinating Centre, Bern, Switzerland
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Christiane Pilop
Christiane Pilop
SAKK Coordinating Centre, Bern, Switzerland
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Hanne Hawle
Hanne Hawle
SAKK Coordinating Centre, Bern, Switzerland
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Peter Brauchli
Peter Brauchli
SAKK Coordinating Centre, Bern, Switzerland
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Coya Tapia
Coya Tapia
Institute of Pathology, University of Bern, Bern, Switzerland
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Wolfgang Schoenfeld
Wolfgang Schoenfeld
CURADIS GmbH, Erlangen, Germany
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Cristiana Sessa
Cristiana Sessa
Istituto Oncologico della Svizzera Italiana, Bellinzona, Switzerland
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for the Swiss Group for Clinical Cancer Research (SAKK)
for the Swiss Group for Clinical Cancer Research (SAKK)
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Introduction For the treatment of breast cancer (BC), testosterone was already used extensively between the 1930s and 1960s with anecdotal tumour responses (especially in bone metastases) seen in up to 20% of treated women ( 1 , 2 , 3 , 4
Chan Sub Park
Chan Sub Park
Department of Breast and Thyroid Surgery, Kyungpook National University Chilgok Hospital, Buk-gu, Daegu, Republic of Korea
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Jihye Choi
Jihye Choi
Department of General Surgery, National Medical Center, Jung-gu, Seoul, Republic of Korea
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Min-Ki Seong
Min-Ki Seong
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Sung-Eun Hong
Sung-Eun Hong
Radiation Medicine Clinical Research Division, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Jae-Sung Kim
Jae-Sung Kim
Radiation Medicine Clinical Research Division, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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In-Chul Park
In-Chul Park
Division of Fusion Radiology Research, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Hyesil Seol
Hyesil Seol
Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Woo Chul Noh
Woo Chul Noh
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Hyun-Ah Kim
Hyun-Ah Kim
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Introduction Estradiol is a key factor for tumorigenesis and prognosis of hormone receptor (HR)-positive breast cancer. Although estradiol is produced mainly by the ovary in premenopausal women, the adrenal gland and adipocytes are also
Anne M Drewes
Anne M Drewes
University of Aarhus, Aarhus C, Denmark
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Maria E Møller
Maria E Møller
The Danish Cancer Society, Denmark (Kræftens Bekæmpelse), København Ø, Denmark
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Rasmus Hertzum-Larsen
Rasmus Hertzum-Larsen
The Danish Cancer Society, Denmark (Kræftens Bekæmpelse), København Ø, Denmark
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Gerda Engholm
Gerda Engholm
The Danish Cancer Society, Denmark (Kræftens Bekæmpelse), København Ø, Denmark
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Hans H Storm
Hans H Storm
The Danish Cancer Society, Denmark (Kræftens Bekæmpelse), København Ø, Denmark
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Introduction Survival after breast cancer has improved substantially worldwide over recent decades. Due to the high and increasing incidence of breast cancer in the developed world, the survivor cohort is big, and the possibility of long
V Kenan Çelik
V Kenan Çelik
Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey
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Sercan Kapancık
Sercan Kapancık
Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey
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Turgut Kaçan
Turgut Kaçan
Department of Medical Oncology, High Specialized Education and Research Hospital, Bursa, Turkey
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Selen Baloglu Kaçan
Selen Baloglu Kaçan
Department of Internal Medicine, Afyonkarahisar State Hospital, Afyon, Turkey
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Serkan Kapancık
Serkan Kapancık
Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey
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Hasan Kılıçgün
Hasan Kılıçgün
Department of Nutrition and Dietetics, Health Science Faculty, University of Erzincan, Erzincan, Turkey
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11 adults has diabetes and this ratio will be increased 1/10 in 2040. Type II diabetes, the most common form of diabetes, increases with changing cultural and social changes. Many years ago, breast cancer was found to be more common in diabetic
Piera Rizzolo
Piera Rizzolo
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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Valentina Silvestri
Valentina Silvestri
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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Virginia Valentini
Virginia Valentini
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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Veronica Zelli
Veronica Zelli
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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Agostino Bucalo
Agostino Bucalo
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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Ines Zanna
Ines Zanna
Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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Simonetta Bianchi
Simonetta Bianchi
Division of Pathological Anatomy, Department of Sciences of Health, University of Florence, Florence, Italy
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Maria Grazia Tibiletti
Maria Grazia Tibiletti
Department of Pathology, ASST Settelaghi and Centro di Ricerca per lo Studio dei Tumori Eredo-Familiari, Università dell’Insubria, Varese, Italy
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Antonio Russo
Antonio Russo
Section of Medical Oncology, Department of Surgical and Oncological and Oral Sciences, University of Palermo, Palermo, Italy
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Liliana Varesco
Liliana Varesco
IRCCS Ospedale Policlinico San Martino, Genoa, Italy
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Gianluca Tedaldi
Gianluca Tedaldi
Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy
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Bernardo Bonanni
Bernardo Bonanni
Division of Cancer Prevention and Genetics IEO, European Institute of Oncology IRCCS, Milan, Italy
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Jacopo Azzollini
Jacopo Azzollini
Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy
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Siranoush Manoukian
Siranoush Manoukian
Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy
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Anna Coppa
Anna Coppa
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Giuseppe Giannini
Giuseppe Giannini
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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Laura Cortesi
Laura Cortesi
Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy
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Alessandra Viel
Alessandra Viel
Unit of Functional Onco-Genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy
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Marco Montagna
Marco Montagna
Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV – IRCCS, Padua, Italy
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Paolo Peterlongo
Paolo Peterlongo
Genome Diagnostics Program, IFOM – The FIRC Institute of Molecular Oncology, Milan, Italy
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Paolo Radice
Paolo Radice
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy
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Domenico Palli
Domenico Palli
Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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Laura Ottini
Laura Ottini
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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Introduction Male breast cancer (MBC) is a rare disease, representing about 1% of all breast cancers (BCs) and less than 1% of all cancers in men ( 1 ). Germline pathogenic variants in BC genes, particularly BRCA1 , BRCA2 and PALB2 genes
Ishita Gupta
Ishita Gupta
Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, Alkoudh, Sultanate of Oman
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Allal Ouhtit
Allal Ouhtit
Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar
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Adil Al-Ajmi
Adil Al-Ajmi
Department of Surgery, College of Medicine and Health Sciences, Sultan Qaboos University, Alkoudh, Sultanate of Oman
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Syed Gauhar A Rizvi
Syed Gauhar A Rizvi
Department of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University, Alkoudh, Sultanate of Oman
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Hamad Al-Riyami
Hamad Al-Riyami
Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, Alkoudh, Sultanate of Oman
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Marwa Al-Riyami
Marwa Al-Riyami
Department of Pathology, College of Medicine and Health Sciences, Sultan Qaboos University, Alkoudh, Sultanate of Oman
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Yahya Tamimi
Yahya Tamimi
Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Alkoudh, Sultanate of Oman
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Introduction Breast cancer is the most common among women, affecting 25% of female population worldwide and more than a million new cases are diagnosed every year ( 1 ). Environmental components are considered serious risk factors, whereas
Juan Carlos Juárez-Cruz
Juan Carlos Juárez-Cruz
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Miriam Daniela Zuñiga-Eulogio
Miriam Daniela Zuñiga-Eulogio
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Monserrat Olea-Flores
Monserrat Olea-Flores
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Eduardo Castañeda-Saucedo
Eduardo Castañeda-Saucedo
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Miguel Ángel Mendoza-Catalán
Miguel Ángel Mendoza-Catalán
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Carlos Ortuño-Pineda
Carlos Ortuño-Pineda
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Ma Elena Moreno-Godínez
Ma Elena Moreno-Godínez
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Sócrates Villegas-Comonfort
Sócrates Villegas-Comonfort
Instituto de Fisiología Celular, Universidad Nacional Autónoma de Mexico, Mexico City, México
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Teresita Padilla-Benavides
Teresita Padilla-Benavides
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
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Napoleón Navarro-Tito
Napoleón Navarro-Tito
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Introduction Breast cancer is the most common invasive neoplasia and the second-leading cause of cancer-related death in women worldwide. Over 2,000,000 cases are diagnosed annually worldwide, which represents the highest incidence of cancer
Cleofas Marcial-Medina
Cleofas Marcial-Medina
Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico
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Alejandra Ordoñez-Moreno
Alejandra Ordoñez-Moreno
Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico
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Christian Gonzalez-Reyes
Christian Gonzalez-Reyes
Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico
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Pedro Cortes-Reynosa
Pedro Cortes-Reynosa
Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico
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Eduardo Perez Salazar
Eduardo Perez Salazar
Departamento de Biologia Celular, Cinvestav-IPN, Mexico City, Mexico
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Introduction Epidemiological studies strongly suggest an association between a higher intake of dietary fat and obesity with an increased risk of developing breast cancer. Moreover, obesity is characterized for an elevation of circulating free
