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preoperative diagnosis of DSVPTC difficult ( 10 , 11 ). Both PTL and DSVPTC are lymphocyte-rich thyroid lesions, but the therapeutic methods for these two diseases are different ( 12 ). PTL is a potentially curable thyroid malignancy, and the main treatment
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Royal Marsden Hospital, London, UK
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be present, the literature to date suggests that they are less frequently detected than in classic autoimmune disease, suggesting a different mechanism of gland dysfunction. The timescale often differs as well, with rapid evolution into complete gland
Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Department of Radiology, HUS Medical Imaging Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Endocrinology, Abdominal Centre, University of Helsinki and HUS, Helsinki, Finland
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Department of Oncology, Comprehensive Cancer Centre, Helsinki University Hospital, Helsinki, Finland
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stage III or IV metastatic melanoma, Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1, no active autoimmune disease or unstable other serious illness, as well as no active brain metastases. Each treatment plan was approved by a
Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
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Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands
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Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, Netherlands
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. However, it is unlikely that a large proportion of our study population had untreated overt thyroid disease during the available observation period of 7.3 years. A recent cohort study from the Netherlands showed that only 0.44% of their study population