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Agata Hanna Bryk-Wiązania Chair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland
Department of Endocrinology, Oncological Endocrinology and Nuclear Medicine, University Hospital, Krakow, Poland

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Mari Minasyan Department of Endocrinology, Oncological Endocrinology and Nuclear Medicine, University Hospital, Krakow, Poland

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Alicja Hubalewska-Dydejczyk Chair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland
Department of Endocrinology, Oncological Endocrinology and Nuclear Medicine, University Hospital, Krakow, Poland

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Aleksandra Gilis-Januszewska Chair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland
Department of Endocrinology, Oncological Endocrinology and Nuclear Medicine, University Hospital, Krakow, Poland

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platelets, increased thrombin generation, elevated concentrations of fibrinogen and fibrinolysis inhibitors, and compensatory elevation of endogenous anticoagulants such as protein C and protein S ( 3 , 4 , 5 , 6 ). However, no linear relationship with

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Eng-Loon Tng Department of Medicine, Level 8, Tower A, Ng Teng Fong General Hospital, Singapore

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Yee Sian Tiong Department of Medicine, Level 8, Tower A, Ng Teng Fong General Hospital, Singapore

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Aye Thida Aung Department of Medicine, Level 8, Tower A, Ng Teng Fong General Hospital, Singapore

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Nicole Ya Yuan Chong Department of Medicine, National University Hospital, Singapore

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Zhemin Wang Department of Medicine, National University Hospital, Singapore

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). However, warfarin and direct oral anticoagulants (DOACs) did not prevent stroke in two retrospective cohort studies ( 6 , 15 ). There are no systematic reviews or Cochrane reviews on this topic. Materials and methods The primary objective is the

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Shenghe Luo College of Pharmacy, Yanbian University, Yanji, China

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Yunhui Zuo Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji, China
Department of Cardiology, Yanbian University Hospital, Yanji, China

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Xiaotian Cui Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji, China

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Meiping Zhang Department of Cardiology, Yanbian University Hospital, Yanji, China

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Honghua Jin Department of Pharmacy, Yanbian University Hospital, Yanji, China

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Lan Hong Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji, China

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the ET tubes containing anticoagulants (10 μL EDTA and 20 μL aprotinin per ET anticoagulant tube) for subsequent ANP assays, the heart was immediately removed at −80°C for subsequent experiments. Determination of ANP content ANP concentrations

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Run-Qing Xiong Department of Ultrasonic Imaging, Xiamen Medical College Affiliated Second Hospital, Fujian, China

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Yan-Ping Li Key Laboratory of Functional and Clinical Translational Medicine, Fujian Province University, Xiamen Medical College, Fujian, China

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Lu-Ping Lin Department of Endocrinology, Xiamen Medical College Affiliated Second Hospital, Fujian, China

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Jeng-Yuan Yao Key Laboratory of Functional and Clinical Translational Medicine, Fujian Province University, Xiamen Medical College, Fujian, China

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compared to the DCM group with P < 0.05; c Significant differences compared to the DCM group with P < 0.01. Sample collection Blood samples were collected into heparinized anticoagulant tubes from all participants. To obtain plasma, the

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