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.3%) Female 185 (36.1%) 188 (36.7%) Age, n (%) 0.063 ≤45 111 (21.7%) 132 (25.8%) >45 145 (28.3%) 124 (24.2%) Pathologic T stage, n (%) 0.554 T1 72 (14.1%) 71 (13.9%) T2 91 (17
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entry into tissues and the deiodinase enzymatic system regulates the generation or inactivation of THs in situ ( 1 ). T3 generation from T4 is catalyzed by the enzymes type 1 deiodinase (DIO1) and type 2 deiodinase (DIO2), whereas T4 or T3 inactivation
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difference in the 25(OH)D levels in terms of tumor size and T stage. Although 25(OH)D levels showed a decreased trend in patients with ETE, this difference was not statistically significant. Figure 1 Flowchart of patient selection. Table 1
The First Affiliated Hospital, Department of Otorhinolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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. According to TNM staging, 8 cases were T1N0M0, 3 cases were T2N0M0, 14 cases were T1N1aM0, 5 cases were T2N1aM0, 2 cases were T3N1aM0, 1 case was T1N1bM0, 3 cases were T2N1bM0, and 2 cases were T3N1bM0. The specimens were immediately obtained after surgery
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.5 Surgical margin Positive 387 27.5 Negative 1020 72.5 pT T1 564 40.2 T2 452 32.2 T3 271 19.3 T4 117 8.3 Regional LN metastasis N0 661 47.0 N1a 206
Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
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143186556 Nonsynonymous SNV Deleterious (0) Probably damaging (1) Probably damaging (0.126) 29.7 Deleterious (0.945) NID1 chr1:236189209 T>G p.I657M rs199655594 Nonsynonymous SNV Deleterious (0.02) Probably damaging (0
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), blood samples were collected, centrifuged at 1400 g for 10 min, and stored at −80°C. At the same time, adipose tissues were surgically removed and frozen in liquid nitrogen until analysis. 3T3-L1 adipocyte cultures and differentiation 3T3-L1
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Background Optimal thyroid function during pregnancy is essential for both the mother and the developing fetus since thyroid hormones regulate the metabolism, growth, maintenance of pregnancy and development of the fetal CNS ( 1 ). During
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supply of its own until well into the second trimester ( 1 ). In addition, type 3 deiodinase in the placenta degrades a proportion of the maternal supply of triiodothyronine (T3, the principal TH), which also increases the need for additional production
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. Lancet. Diabetes and Endocrinology 2022 10 299 – 301 . ( https://doi.org/10.1016/S2213-8587(2200079-1 ) 31 Osinga JAJ Derakhshan A Palomaki GE Ashoor G Männistö T Maraka S Chen L Bliddal S Lu X Taylor PN , et al. TSH and FT4