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Anna Gorbacheva Endocrinology Research Center, Moscow, Russian Federation

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Anna Eremkina Endocrinology Research Center, Moscow, Russian Federation

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Daria Goliusova Endocrinology Research Center, Moscow, Russian Federation

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Julia Krupinova Endocrinology Research Center, Moscow, Russian Federation

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Natalia Mokrysheva Endocrinology Research Center, Moscow, Russian Federation

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Introduction Menin is a highly conserved protein encoded by the ubiquitously expressed MEN1 gene. It partakes in the regulation of various intracellular processes, including transcription, maintaining genome stability, proliferation and

Article Type:
Review Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0494
Volume/Issue:
Volume 11: Issue 3
Open access
Eleftherios E Deiktakis Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Greece

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Eleftheria Ieronymaki Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Greece

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Peter Zarén Department of Translational Medicine, Lund University, Malmö, Sweden

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Agnes Hagsund Department of Translational Medicine, Lund University, Malmö, Sweden

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Elin Wirestrand Department of Translational Medicine, Lund University, Malmö, Sweden

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Johan Malm Department of Translational Medicine, Lund University, Malmö, Sweden

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Christos Tsatsanis Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Greece

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Ilpo T Huhtaniemi Department of Translational Medicine, Lund University, Malmö, Sweden
Imperial College London, Institute of Reproductive and Developmental Biology, London, UK

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Aleksander Giwercman Department of Translational Medicine, Lund University, Malmö, Sweden
Malmö University Hospital, Reproductive Medicine Center, Malmö, Sweden

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Yvonne Lundberg Giwercman Department of Translational Medicine, Lund University, Malmö, Sweden

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( Fig. 1B ). Sixteen men were on the same occasion treated with 300 IU follitropin α rFSH (Gonal-f), and the rest ( n   = 17) were untreated. Subsequently, the same dose of rFSH was self-administered three times/week for the rest of the study period, in

Article Type:
Research Article
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Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0639
Volume/Issue:
Volume 11: Issue 6
Open access
Hélène Singeisen Department of Internal Medicine, Endocrinology, Cantonal Hospital Thurgau, Münsterlingen, Switzerland

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Mariko Melanie Renzulli Institute of Radiology, Cantonal Hospital Thurgau, Frauenfeld, Switzerland

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Vojtech Pavlicek Department of Internal Medicine, Endocrinology, Cantonal Hospital Thurgau, Münsterlingen, Switzerland

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Pascal Probst Department of Surgery, Cantonal Hospital Thurgau, Frauenfeld, Switzerland

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Fabian Hauswirth Department of Surgery, Cantonal Hospital Thurgau, Münsterlingen, Switzerland

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Markus K Muller Department of Surgery, Cantonal Hospital Thurgau, Frauenfeld, Switzerland

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Magdalene Adamczyk Department of Pathology and Molecular Pathology, University Hospital Zurich and University of Zurich, Zurich, Switzerland

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Achim Weber Department of Pathology and Molecular Pathology, University Hospital Zurich and University of Zurich, Zurich, Switzerland

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Reto Martin Kaderli Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland

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Pietro Renzulli Department of Surgery, Cantonal Hospital Thurgau, Münsterlingen, Switzerland

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-Vickers/Williams-Pollock/Wagenmann–Froboese syndrome --- --- OMIM ® #131100 #171400 #162300 #610755 --- Gene MEN1 RET RET CDKN1B MAX Location 11q13.1 10q11.21 10q11.21 12p13.1 14q23.3 Inheritance Autosomal-dominant Autosomal

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-22-0411
Volume/Issue:
Volume 12: Issue 2
Open access
Arnaud Lagarde Aix Marseille Univ, APHM, INSERM, MMG, Laboratory of Molecular Biology Hospital La Conception, Marseille, France

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Grégory Mougel Aix Marseille Univ, APHM, INSERM, MMG, Laboratory of Molecular Biology Hospital La Conception, Marseille, France

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Lucie Coppin Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 – CANTHER – Cancer – Heterogeneity Plasticity and Resistance to Therapies, Lille, France

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Magalie Haissaguerre Service d’Endocrinologie, Centre Hospitalier Universitaire, Hôpital du Haut Levêque, Pessac, France

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Lauriane Le Collen Endocrinology, Diabetology and Nutrition Unit, University Hospital of Reims, Reims, France
Inserm/CNRS UMR 1283/8199, Pasteur Institute of Lille, EGID, Lille, France

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Amira Mohamed Laboratory of Molecular Biology, Hospital La Conception, APHM, Marseille, France

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Marc Klein Service Endocrinologie, CHU de Nancy, Hôpital de Brabois, Vandoeuvre-lès-Nancy, France

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Marie-Françoise Odou CHU Lille, Service de Biochimie et Biologie Moléculaire ‘Hormonologie, Métabolisme-Nutrition, Oncologie’, Lille, France
Univ. Lille, Inserm, CHU Lille, U1286 – Infinite – Institute for Translational Research in Inflammation, Lille, France

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Antoine Tabarin Service d’Endocrinologie, Centre Hospitalier Universitaire, Hôpital du Haut Levêque, Pessac, France

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Hedia Brixi Department of Gastroenterology and Digestive Oncology, Reims University Hospital, Reims, France

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Thomas Cuny Aix Marseille Univ, APHM, INSERM, MMG, Department of Endocrinology, Hospital La Conception, Marseille, France

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Brigitte Delemer Endocrinology, Diabetology and Nutrition Unit, University Hospital of Reims, Reims, France

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Anne Barlier Aix Marseille Univ, APHM, INSERM, MMG, Laboratory of Molecular Biology Hospital La Conception, Marseille, France

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Pauline Romanet Aix Marseille Univ, APHM, INSERM, MMG, Laboratory of Molecular Biology Hospital La Conception, Marseille, France

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Introduction Multiple endocrine neoplasia type 1 (MEN1, OMIM 131100) is an autosomal dominant disease due to mutation in the MEN1 gene, characterized by a broad spectrum of clinical manifestations ( 1 ). The classic clinical triad includes

Article Type:
Research Article
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Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-22-0093
Volume/Issue:
Volume 11: Issue 11
Open access
Josephina G Kuiper PHARMO Institute for Drug Outcomes Research, AE Utrecht, Netherlands
Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands

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Aline C Fenneman Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Anne H van der Spek Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Elena Rampanelli Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Max Nieuwdorp Department of Clinical and Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Myrthe P P van Herk-Sukel Department of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, Netherlands

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Valery E P P Lemmens Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands

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Ernst J Kuipers Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, Netherlands

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Ron M C Herings PHARMO Institute for Drug Outcomes Research, AE Utrecht, Netherlands
Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, Netherlands

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Eric Fliers Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

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Introduction Primary hypothyroidism is a common condition with a rapidly rising global prevalence. In the Netherlands, the prevalence of overt hypothyroidism has increased from 0.4 to 2.9% over the past 15 years ( 1 ) ( www

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Research Article
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Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0463
Volume/Issue:
Volume 11: Issue 1
Open access
Vita Birzniece School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Garvan Institute of Medical Research, New South Wales, Australia
School of Medical Sciences, University of New South Wales, New South Wales, Australia

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Teresa Lam School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, New South Wales, Australia

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Mark McLean School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia

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Navneeta Reddy Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia

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Haleh Shahidipour School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia

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Amy Hayden School of Medicine, Western Sydney University, New South Wales, Australia
Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia

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Howard Gurney Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia

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Glenn Stone School of Computing, Engineering and Mathematics, Western Sydney University, New South Wales, Australia

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Rikke Hjortebjerg Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark

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Jan Frystyk Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark

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hypogonadism, it is associated with the development of obesity, insulin resistance, hyperinsulinemia, and increased cardiovascular disease risk ( 1 , 2 ). The metabolic syndrome is present in >50% of men receiving long-term ADT compared to 20% of matched

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Research Article
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Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0375
Volume/Issue:
Volume 11: Issue 4
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Kazhan Mollazadegan Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Britt Skogseid Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Johan Botling Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

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Tobias Åkerström Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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Barbro Eriksson Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Staffan Welin Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Anders Sundin Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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Joakim Crona Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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grading of panNENs ( 3 ), high-grade neoplasms were separated into two categories: well-differentiated (WD) pancreatic neuroendocrine tumor grade 3 (panNET-G3) and poorly differentiated (PD) NEC ( 4 ). PanNET-G3 frequently harbors mutations in MEN1 and

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Research Article
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Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0604
Volume/Issue:
Volume 11: Issue 3
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Peiwen Wu Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

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Dongjie He Department of Radiation Oncology, Tangdu Hospital, the Second Affiliated Hospital of Air Force Medical University, Xi’an, China

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Hao Chang Department of Radiation Oncology, Tangdu Hospital, the Second Affiliated Hospital of Air Force Medical University, Xi’an, China

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Xiaozhi Zhang Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

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worse prognosis. This is consistent with the results of previous studies ( 1 , 13 , 44 ). Possible explanations for the poorer prognosis in men are that estrogen and progesterone receptor expression is associated with the prognosis of patients with

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Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-23-0331
Volume/Issue:
Volume 12: Issue 12
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Malgorzata Fuksiewicz Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

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Maria Kowalska Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

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Agnieszka Kolasinska-Cwikla Department of Oncology and Radiotherapy, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

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Beata Kotowicz Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

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the degree of brain damage, for example, in patients after cardiac arrest ( 1 , 2 ). Increased NSE concentrations are also observed in the course of neoplastic diseases. Increasing concentrations of the marker in patients with initially diagnosed

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Research Article
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Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0647
Volume/Issue:
Volume 11: Issue 9
Open access