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secretion is increased by inflammatory stimuli in an IL-6-dependent manner, leading to hyperinsulinemia and blood glucose lowering . Diabetes 2014 63 3221 – 3229 . ( https://doi.org/10.2337/db14-0100 ) 34 Timper K Dalmas E Dror E Rutti S Thienel
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display heightened levels of circulating inflammatory markers such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), IL-1β, and monocyte chemoattractant protein 1 (MCP-1), as well as decreased plasma levels of anti-inflammatory cytokines
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/mL) 3.94 ± 2.23 3.53 ± 1.42 0.647 IL-8 (pg/mL) 117.34 ± 115.86 92.73 ± 91.27 0.420 IL-10 (pg/mL) 5.07 ± 0.33 5.13 ± 0.60 0.796 TNF-α (pg/mL) 7.25 ± 1.85 7.34 ± 1.77 0.832 Data are presented as mean ± s
Postgraduate Program in Nutritional Sciences, Department of Nutrition, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
University Centre of João Pessoa (UNIPE), João Pessoa, Paraíba, Brazil
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Postgraduate Program in Cognitive Neuroscience and Behavior, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Department of Biorregulation, Health Sciences Institute, Federal University of Bahia, Bahia, Brazil
Postgraduate Program in Medicine and Health, Medical School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil
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.78 0.50 0.03 3.45 1.39–8.67 0.011 d -dimer (ng/mL) 0.63 0.51–0.74 >946 0.64 0.60 0.02 2.63 1.12–5.95 0.023 IL6 (pg/mL) 0.55 0.43–0.67 >130 0.34 0.85 0.33 3.07 1.25–7.24 0.015 Neutrophils 0
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repaired, exposed to hydrogen peroxide for 10 min, blocked, and incubated with corresponding primary antibodies against nephrin (1:500), GLP-1R (1:250), IL-1β (1:200), and NLRP3 (1:200) overnight at 4°C, FITC/CY3-labeled fluorescent secondary antibody (1
Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China
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the production of tumor necrosis factor-α, interleukin (IL)-6, and IL-1, as well as the inflammatory reaction of macrophages while increasing the synthesis of anti-inflammatory cytokines like IL-4 and IL-10 ( 15 , 16 ). However, metformin has a
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.82 BMI (kg/m 2 ) 18.5 ± 2.6 20.4 ± 3.4 <0.01 BMI-SDS 0.50 ± 0.92 0.61 ± 0.95 0.07 HbA1c (%) 7.7 ± 1.7 7.3 ± 1.2 0.07 Bold indicates statistical significance. HbA1c, glycosylated hemoglobin. In particular
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) 31 (28–34) a 33 (29–36) b 34 (30–38) c 33 (29–36) b <0.001 1: <30 592, 40.22% 2435, 26.20% 489, 21.20% 102, 26.84% 2: ≥30 and <40 829, 56.32% 5941, 63.93% 1450, 62.85% 234, 61.58% 3: ≥40 51, 3
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volume in women with PCOS and controls. PCOS ( n = 1614) Controls ( n = 362) P Age (years) 25.14 ± 5.56 30.36 ± 5.96 0.027 BMI (kg/m 2 ) 27.34 ± 7.09 25.49 ± 5.97 <0.001 WHR 0.79 ± 0.08 0.78 ± 0
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in GDM such as 8-isoprostane (8IsoP), TNF-α, and IL-10 have been studied in a very limited number of reports, in which the results are contradictory, though some showed higher levels of oxidative stress markers in pregnancies with GDM ( 9 , 10 ). P