Nadia Sabbah
Nadia Sabbah
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
Hôpital de Cayenne, Service d’Endocrinologie et des Maladies Métaboliques, Cayenne, Guyane Française
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Hôpital de Cayenne, Service d’Endocrinologie et des Maladies Métaboliques, Cayenne, Guyane Française
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Peter Wolf
Peter Wolf
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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Céline Piedvache
Céline Piedvache
Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Unité de Recherche Clinique, Le Kremlin-Bicêtre, France
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Séverine Trabado
Séverine Trabado
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Le Kremlin-Bicêtre, France
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Tristan Verdelet
Tristan Verdelet
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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Catherine Cornu
Catherine Cornu
Centre d’Investigation Clinique, INSERM CIC1407/UMR5558, Hospices Civils de Lyon, Bron, France
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Jean-Claude Souberbielle
Jean-Claude Souberbielle
Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Service d’Explorations Fonctionnelles, Paris, France
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Philippe Chanson
Philippe Chanson
Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
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Introduction IGF-1 measurement is important for the diagnosis and management of patients with growth hormone (GH) deficiency or acromegaly as well as in their follow-up ( 1 , 2 ). We previously established normative data for six IGF-I assays
Gudmundur Johannsson
Gudmundur Johannsson
Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Martin Bidlingmaier
Martin Bidlingmaier
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany
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Beverly M K Biller
Beverly M K Biller
Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
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Margaret Boguszewski
Margaret Boguszewski
Federal University of Parana, Curitiba, Brazil
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Felipe F Casanueva
Felipe F Casanueva
Department of Medicine, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain
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Philippe Chanson
Philippe Chanson
Assistance Publique-Hôpitaux de Paris, and Inserm, Paris, France
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Peter E Clayton
Peter E Clayton
Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK
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Catherine S Choong
Catherine S Choong
Department of Endocrinology, Princess Margaret Hospital & School of Medicine, University of Western Australia, Western Australia, Australia
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David Clemmons
David Clemmons
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
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Mehul Dattani
Mehul Dattani
Great Ormond Street Institute of Child Health, London, UK
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Jan Frystyk
Jan Frystyk
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Ken Ho
Ken Ho
Princess Alexandra Hospital and University of Queensland, Brisbane, Australia
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Andrew R Hoffman
Andrew R Hoffman
Department of Medicine, Stanford University and VA Palo Health Care System, Palo Alto, California, USA
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Reiko Horikawa
Reiko Horikawa
National Center for Child Health and Development, Tokyo, Japan
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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John J Kopchick
John J Kopchick
Edison Biotechnology Institute and Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
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Xiaoping Luo
Xiaoping Luo
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Sebastian Neggers
Sebastian Neggers
Section of Endocrinology, Department of Medicine, Pituitary Centre Rotterdam, Erasmus University Medical Centre, Rotterdam, the Netherlands
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Irene Netchine
Irene Netchine
Service d’Explorations Fonctionnelles Endocriniennes, AP-HP, Hôpital Trousseau, Sorbonne Université, INSERM UMRs 938, Paris, France
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Daniel S Olsson
Daniel S Olsson
Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden
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Sally Radovick
Sally Radovick
Rutgers University-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
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Ron Rosenfeld
Ron Rosenfeld
Department of Pediatrics, Oregon Health Science University, Portland, Oregon, USA
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Richard J Ross
Richard J Ross
University of Sheffield, Sheffield, UK
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Katharina Schilbach
Katharina Schilbach
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany
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Paulo Solberg
Paulo Solberg
Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
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Christian Strasburger
Christian Strasburger
Charité-Universitätsmedizin, Berlin, Germany
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Peter Trainer
Peter Trainer
The Christie NHS Foundation Trust, University of Manchester, Manchester, UK
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Kevin C J Yuen
Kevin C J Yuen
Barrow Pituitary Center, Barrow Neurological Institute, Department of Neuroendocrinology, University of Arizona College of Medicine, Phoenix, Arizona, USA
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Kerstin Wickstrom
Kerstin Wickstrom
Medical Products Agency, Uppsala, Sweden
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Jens O L Jorgensen
Jens O L Jorgensen
Aarhus University Hospital, Aarhus, Denmark
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on behalf of the Growth Hormone Research Society
on behalf of the Growth Hormone Research Society
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factor-I (IGF-I). Both are used diagnostically; IGF-I is used to monitor the effects of GH replacement in GH deficiency (GHD), and both GH and IGF-I are used in the diagnosis and management of acromegaly. While serum IGF-I level is used as a surrogate
P R van Dijk
P R van Dijk
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
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S J J Logtenberg
S J J Logtenberg
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
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Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
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K H Groenier
K H Groenier
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
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Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
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N Kleefstra
N Kleefstra
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
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Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
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H J G Bilo
H J G Bilo
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
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Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
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H J Arnqvist
H J Arnqvist
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
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Diabetes Centre, Departments of Internal Medicine, General Practice, Langerhans Medical Research Group, Department of Internal Medicine, Division of Cell Biology, Faculty of Health Sciences, Isala Clinics, PO Box 10400, 8000 G.K. Zwolle, The Netherlands
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the start of the s.c. and i.p. insulin treatment phases were respectively 83.7±31.9 and 76.3±24.5 μg/l. IGF1 and IGFBP1 concentrations Results obtained for the IGF1 and IGFBP1 measurements during the different treatment modalities are summarized in
Urszula Smyczyńska
Urszula Smyczyńska
Department of Automatics and Biomedical Engineering, AGH University of Science and Technology, Krakow, Poland
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Joanna Smyczyńska
Joanna Smyczyńska
Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland
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Maciej Hilczer
Maciej Hilczer
Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland
Department of Paediatric Endocrinology, Medical University of Lodz, Lodz, Poland
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Department of Paediatric Endocrinology, Medical University of Lodz, Lodz, Poland
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Renata Stawerska
Renata Stawerska
Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland
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Ryszard Tadeusiewicz
Ryszard Tadeusiewicz
Department of Automatics and Biomedical Engineering, AGH University of Science and Technology, Krakow, Poland
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Andrzej Lewiński
Andrzej Lewiński
Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland
Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland
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Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland
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), in some of them also concentrations of IGF-I ( 7 , 8 , 9 , 13 ) and IGFBP-3 ( 7 , 9 ) have been processed. The most frequently used method of deriving models of GH therapy outcomes has been multiple linear regression (MLR) ( 6 , 7 , 10 , 11
M Krause
M Krause
Department of Growth and Reproduction & International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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H Frederiksen
H Frederiksen
Department of Growth and Reproduction & International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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K Sundberg
K Sundberg
Center of Fetal Medicine and Pregnancy, Department of Obstetrics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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F S Jørgensen
F S Jørgensen
Fetal Medicine Unit, Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Denmark
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L N Jensen
L N Jensen
Center of Fetal Medicine and Pregnancy, Department of Obstetrics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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P Nørgaard
P Nørgaard
Fetal Medicine Unit, Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Denmark
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C Jørgensen
C Jørgensen
Center of Fetal Medicine and Pregnancy, Department of Obstetrics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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P Ertberg
P Ertberg
Fetal Medicine Unit, Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Denmark
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J H Petersen
J H Petersen
Department of Growth and Reproduction & International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Section of Biostatistics, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark
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Section of Biostatistics, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark
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U Feldt-Rasmussen
U Feldt-Rasmussen
Department of Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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A Juul
A Juul
Department of Growth and Reproduction & International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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K T Drzewiecki
K T Drzewiecki
Department of Plastic Surgery, Breast Surgery and Burns Treatment, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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N E Skakkebaek
N E Skakkebaek
Department of Growth and Reproduction & International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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A M Andersson
A M Andersson
Department of Growth and Reproduction & International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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factor I (IGF-I) and its major binding protein: insulin-like growth factor-binding protein-3 (IGFBP3). IGF-I and IGFBP3 were both measured by a chemiluminescence immunoassay on the IDS-iSYS automated platform (Immuno Diagnostic Systems, IDS) at the
Monika Bilic
Monika Bilic
Centre for Global Child Health, Hospital for Sick Children, Toronto, Canada
Department of Nutritional Sciences, University of Toronto, Toronto, Canada
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Department of Nutritional Sciences, University of Toronto, Toronto, Canada
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Huma Qamar
Huma Qamar
Centre for Global Child Health, Hospital for Sick Children, Toronto, Canada
Department of Nutritional Sciences, University of Toronto, Toronto, Canada
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Department of Nutritional Sciences, University of Toronto, Toronto, Canada
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Akpevwe Onoyovwi
Akpevwe Onoyovwi
Centre for Global Child Health, Hospital for Sick Children, Toronto, Canada
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Jill Korsiak
Jill Korsiak
Centre for Global Child Health, Hospital for Sick Children, Toronto, Canada
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Eszter Papp
Eszter Papp
Centre for Global Child Health, Hospital for Sick Children, Toronto, Canada
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Abdullah Al Mahmud
Abdullah Al Mahmud
Nutrition and Clinical Services Division, icddr,b, Dhaka, Bangladesh
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Rosanna Weksberg
Rosanna Weksberg
Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada
Molecular and Medical Genetics, University of Toronto, Toronto, Canada
Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada
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Molecular and Medical Genetics, University of Toronto, Toronto, Canada
Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada
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Alison D Gernand
Alison D Gernand
Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA
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Jennifer Harrington
Jennifer Harrington
Division of Endocrinology, Hospital for Sick Children, Toronto, Canada
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Daniel E Roth
Daniel E Roth
Centre for Global Child Health, Hospital for Sick Children, Toronto, Canada
Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada
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Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada
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improve growth-related outcomes. The insulin-like growth factor (IGF) axis includes several signal and binding proteins, many of which are under the regulation of growth hormone. IGF-I is the primary regulator of fetal growth, and its circulating
Werner F Blum
Werner F Blum
University Children’s Hospital, Giessen, Germany
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Abdullah Alherbish
Abdullah Alherbish
Al Habib Medical Group, Riyadh, Saudi Arabia
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Afaf Alsagheir
Afaf Alsagheir
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
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Ahmed El Awwa
Ahmed El Awwa
Department of Pediatric Endocrinology & Diabetes, Hamad Medical Center, Doha, Qatar
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Walid Kaplan
Walid Kaplan
Tawam Hospital, Al Ain, UAE
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Ekaterina Koledova
Ekaterina Koledova
Global Medical Affairs Endocrinology, Merck KGaA, Darmstadt, Germany
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Martin O Savage
Martin O Savage
William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, London, UK
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Introduction The growth hormone (GH)–insulin-like growth factor (IGF)-I axis is the principle endocrine system regulating linear growth in children ( 1 ). Linked to the nutritional status of the individual, GH is a potent stimulator of IGF-I
Mieke Van Hemelrijck
Mieke Van Hemelrijck
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Thurkaa Shanmugalingam
Thurkaa Shanmugalingam
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Cecilia Bosco
Cecilia Bosco
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Wahyu Wulaningsih
Wahyu Wulaningsih
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Sabine Rohrmann
Sabine Rohrmann
Cancer Epidemiology Group, Division of Chronic Disease Epidemiology, Division of Cancer Studies, King's College London, London, UK
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's College London. References 1 Furstenberger G Senn HJ . Insulin-like growth factors and cancer . Lancet Oncology 2002 3 298 – 302 . ( doi:10.1016/S1470-2045(02)00731-3 ). 2 Colao A . The GH–IGF-I axis and the cardiovascular system: clinical
Martin Bidlingmaier
Martin Bidlingmaier
Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians University, Munich, Germany
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Helena Gleeson
Helena Gleeson
Department of Endocrinology, Queen Elizabeth Hospital, Birmingham, UK
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Ana-Claudia Latronico
Ana-Claudia Latronico
Department of Internal Medicine, Discipline of Endocrinology and Metabolism, Sao Paulo Medical School, University of Sao Paulo, Sao Paulo, Brazil
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Martin O Savage
Martin O Savage
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK
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of benefit) based on scientific evidence ( 5 ). IGF-I as a biomarker for GH status Many components in the blood are sensitive to GH and so could be candidate biomarkers for GH levels and, thus, be used to determine GH deficiency and the need for
Elvira C Arellanes-Licea
Elvira C Arellanes-Licea
Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro, México
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José Ávila-Mendoza
José Ávila-Mendoza
Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro, México
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Elizabeth C Ramírez-Martínez
Elizabeth C Ramírez-Martínez
Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro, México
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Eugenia Ramos
Eugenia Ramos
Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro, México
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Nancy Uribe-González
Nancy Uribe-González
Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro, México
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Carlos Arámburo
Carlos Arámburo
Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro, México
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Teresa Morales
Teresa Morales
Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro, México
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Maricela Luna
Maricela Luna
Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro, México
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://doi.org/10.1159/000262529 ) 21 Isgaard J Aberg D Nilsson M. Protective and regenerative effects of the GH/IGF-I axis on the brain . Minerva Endocrinologica 2007 32 103 – 113 . 22 Arce VM Devesa P Devesa J. Role of growth hormone (GH) in the
