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various diseases, including thyroid cancer ( 3 , 4 ). This regulation includes DNA methylation, chromatin remodeling, histone modifications, and the expression of diverse non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long ncRNAs (lncRNAs), and
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( 7 ). The main driver mutations appear in the BRAF and RAS genes, leading to deregulation in MAPK pathway signaling, resulting in distinct clinicopathological characteristics and different gene expression and DNA methylation profiles ( 8