Search for other papers by Stavroula A Paschou in
Google Scholar
PubMed
Search for other papers by Eleni Palioura in
Google Scholar
PubMed
Search for other papers by Dimitrios Ioannidis in
Google Scholar
PubMed
Search for other papers by Panagiotis Anagnostis in
Google Scholar
PubMed
Search for other papers by Argyro Panagiotakou in
Google Scholar
PubMed
Search for other papers by Vasiliki Loi in
Google Scholar
PubMed
Search for other papers by Georgios Karageorgos in
Google Scholar
PubMed
Search for other papers by Dimitrios G Goulis in
Google Scholar
PubMed
Search for other papers by Andromachi Vryonidou in
Google Scholar
PubMed
degree of insulin resistance ( 7 ). Androgens are mainly of ovarian origin but in 30% of the patients, they originate from the adrenal glands ( 8 ), the main representative being dehydroepiandrosterone sulfate (DHEA-S). The effect of this specific (mainly
Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
Search for other papers by Emanuelle Nunes-Souza in
Google Scholar
PubMed
Search for other papers by Mônica Evelise Silveira in
Google Scholar
PubMed
Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
Search for other papers by Monalisa Castilho Mendes in
Google Scholar
PubMed
Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
Search for other papers by Seigo Nagashima in
Google Scholar
PubMed
Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
Search for other papers by Caroline Busatta Vaz de Paula in
Google Scholar
PubMed
Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
Search for other papers by Guilherme Guilherme Vieira Cavalcante da Silva in
Google Scholar
PubMed
Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
Search for other papers by Giovanna Silva Barbosa in
Google Scholar
PubMed
Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Search for other papers by Julia Belgrowicz Martins in
Google Scholar
PubMed
Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
Search for other papers by Lúcia de Noronha in
Google Scholar
PubMed
Search for other papers by Luana Lenzi in
Google Scholar
PubMed
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
Search for other papers by José Renato Sales Barbosa in
Google Scholar
PubMed
Search for other papers by Rayssa Danilow Fachin Donin in
Google Scholar
PubMed
Search for other papers by Juliana Ferreira de Moura in
Google Scholar
PubMed
Laboratório Central de Análises Clínicas, Hospital de Clínicas, Universidade Federal do Paraná, Centro, Curitiba, Paraná, Brazil
Search for other papers by Gislaine Custódio in
Google Scholar
PubMed
Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
Search for other papers by Cleber Machado-Souza in
Google Scholar
PubMed
Search for other papers by Enzo Lalli in
Google Scholar
PubMed
Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
Departamento de Saúde Coletiva, Universidade Federal do Paraná, Curitiba, Paraná, Brazil
Search for other papers by Bonald Cavalcante de Figueiredo in
Google Scholar
PubMed
regression investigated the decreased DHEAS in each age range. Mean and s.d. values for ZR cell number was evaluated using independent Student’s t -test. A P value < 0.05 was considered statistically significant. Results DHEAS in girls
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Maki Igarashi in
Google Scholar
PubMed
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Tadayuki Ayabe in
Google Scholar
PubMed
Search for other papers by Kiwako Yamamoto-Hanada in
Google Scholar
PubMed
Search for other papers by Keiko Matsubara in
Google Scholar
PubMed
Search for other papers by Hatoko Sasaki in
Google Scholar
PubMed
Search for other papers by Mayako Saito-Abe in
Google Scholar
PubMed
Search for other papers by Miori Sato in
Google Scholar
PubMed
Search for other papers by Nathan Mise in
Google Scholar
PubMed
Search for other papers by Akihiko Ikegami in
Google Scholar
PubMed
Search for other papers by Masayuki Shimono in
Google Scholar
PubMed
Search for other papers by Reiko Suga in
Google Scholar
PubMed
Research Center for Environment and Developmental Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Search for other papers by Shouichi Ohga in
Google Scholar
PubMed
Research Center for Environment and Developmental Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Search for other papers by Masafumi Sanefuji in
Google Scholar
PubMed
Search for other papers by Masako Oda in
Google Scholar
PubMed
Search for other papers by Hiroshi Mitsubuchi in
Google Scholar
PubMed
Search for other papers by Takehiro Michikawa in
Google Scholar
PubMed
Search for other papers by Shin Yamazaki in
Google Scholar
PubMed
Search for other papers by Shoji Nakayama in
Google Scholar
PubMed
Search for other papers by Yukihiro Ohya in
Google Scholar
PubMed
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Maki Fukami in
Google Scholar
PubMed
.12 Hormone measurements Serum levels of E 2 , testosterone, and dehydroepiandrosterone sulfate (DHEA-S) were measured using LC-MS/MS (LSI Medience, Tokyo, Japan). The methods were described previously ( 7 ). The lower detection limits of E 2 , testosterone
Search for other papers by Thomas Reinehr in
Google Scholar
PubMed
Search for other papers by Alexandra Kulle in
Google Scholar
PubMed
Search for other papers by Juliane Rothermel in
Google Scholar
PubMed
Search for other papers by Caroline Knop-Schmenn in
Google Scholar
PubMed
Search for other papers by Nina Lass in
Google Scholar
PubMed
Search for other papers by Christina Bosse in
Google Scholar
PubMed
Search for other papers by Paul-Martin Holterhus in
Google Scholar
PubMed
, 21-deoxycorticosterone, deoxycorticosterone, corticosterone, 11-deoxycortisol, cortisol, cortisone, androstenedione, testosterone, dehydroepiandrostenedione sulfate (DHEA-S), estrone (E1), estradiol (E2), luteinizing hormone (LH), follicle
Department of Medicine, Haukeland University Hospital, Bergen, Norway
Search for other papers by Grethe Å Ueland in
Google Scholar
PubMed
Search for other papers by Thea Grinde in
Google Scholar
PubMed
Department of Medicine, Haukeland University Hospital, Bergen, Norway
K. G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
Search for other papers by Paal Methlie in
Google Scholar
PubMed
Search for other papers by Oskar Kelp in
Google Scholar
PubMed
K. G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
Search for other papers by Kristian Løvås in
Google Scholar
PubMed
Department of Medicine, Haukeland University Hospital, Bergen, Norway
K. G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
Search for other papers by Eystein S Husebye in
Google Scholar
PubMed
) 72 (2–321) LDDST, median, nmol/L (range) 89 (58–517) Continuous data as median and range. Lower limit of quantification for p-ACTH, s-cortisol after DST and s-DHEAS was put as registered value for all patients who tested below
Department of Pediatrics, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil
Search for other papers by Letícia Ribeiro Oliveira in
Google Scholar
PubMed
Search for other papers by Carlos Alberto Longui in
Google Scholar
PubMed
Department of Pediatrics, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil
Search for other papers by Guilherme Guaragna-Filho in
Google Scholar
PubMed
Poison Control Center, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by José Luiz Costa in
Google Scholar
PubMed
Search for other papers by Rafael Lanaro in
Google Scholar
PubMed
Search for other papers by David Antônio Silva in
Google Scholar
PubMed
Search for other papers by Maria Izabel Chiamolera in
Google Scholar
PubMed
Laboratory of Human Molecular Genetics, Center for Molecular Biology and Genetics Engineering (CBMEG), UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by Maricilda Palandi de Mello in
Google Scholar
PubMed
Search for other papers by André Moreno Morcillo in
Google Scholar
PubMed
Department of Medical Genetics and Genomic Medicine, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by Andrea Trevas Maciel-Guerra in
Google Scholar
PubMed
Department of Pediatrics, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by Gil Guerra-Junior in
Google Scholar
PubMed
analysis between IA and LC-MS/MS. x = LC-MS/MS; y = IA. Table 3 Intraclass correlation coefficient (ICC) and Spearman’s correlation coefficient (SCC) between the values of total testosterone, DHEA, androstenedione and DHT through IA vs LC
Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
Search for other papers by Sebastião Freitas de Medeiros in
Google Scholar
PubMed
Search for other papers by Cinthia Marenza Ormond in
Google Scholar
PubMed
Search for other papers by Matheus Antônio Souto de Medeiros in
Google Scholar
PubMed
Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
Search for other papers by Nayara de Souza Santos in
Google Scholar
PubMed
Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
Search for other papers by Camila Regis Banhara in
Google Scholar
PubMed
Search for other papers by Márcia Marly Winck Yamamoto in
Google Scholar
PubMed
-DOC, compound S) <0.2 µmol/L) ( 4 , 17 ). Biochemical hyperandrogenism (hyperandrogenemic PCOS) was defined by total testosterone (T) ≥2.1 nmol/L, DHEAS ≥6.7 µmol/L, A4 ≥8.6 nmol/L and free androgen index (FAI) ≥6 ( 4 , 18 , 19 ). Polycystic ovary
Search for other papers by Ahmet Uçar in
Google Scholar
PubMed
Search for other papers by Nurçin Saka in
Google Scholar
PubMed
Search for other papers by Firdevs Baş in
Google Scholar
PubMed
Search for other papers by Nihal Hatipoğlu in
Google Scholar
PubMed
Search for other papers by Rüveyde Bundak in
Google Scholar
PubMed
Search for other papers by Feyza Darendeliler in
Google Scholar
PubMed
:10.1056/NEJM198612113152405 ). 7 Kiechl S Willeit J Bonora E Schwarz S Xu Q . No association between DHEA-S and development of atherosclerosis in a prospective population study (Bruneck Study
Search for other papers by Aneta Gawlik in
Google Scholar
PubMed
Search for other papers by Michael Shmoish in
Google Scholar
PubMed
Search for other papers by Michaela F Hartmann in
Google Scholar
PubMed
Search for other papers by Stefan A Wudy in
Google Scholar
PubMed
Search for other papers by Zbigniew Olczak in
Google Scholar
PubMed
Search for other papers by Katarzyna Gruszczynska in
Google Scholar
PubMed
Search for other papers by Ze’ev Hochberg in
Google Scholar
PubMed
catabolized and conjugated by liver enzymes, we have anticipated that NAFLD would have its metabolic impact on steroid metabolism. Here, we utilized our previously reported concept, arguing that an individual’s urinary steroid metabolite profile represents a
Search for other papers by Soraya Puglisi in
Google Scholar
PubMed
Search for other papers by Paola Perotti in
Google Scholar
PubMed
Search for other papers by Mattia Barbot in
Google Scholar
PubMed
Search for other papers by Paolo Cosio in
Google Scholar
PubMed
Search for other papers by Carla Scaroni in
Google Scholar
PubMed
Search for other papers by Antonio Stigliano in
Google Scholar
PubMed
Search for other papers by Pina Lardo in
Google Scholar
PubMed
Search for other papers by Valentina Morelli in
Google Scholar
PubMed
Search for other papers by Elisa Polledri in
Google Scholar
PubMed
Search for other papers by Iacopo Chiodini in
Google Scholar
PubMed
Search for other papers by Giuseppe Reimondo in
Google Scholar
PubMed
Search for other papers by Anna Pia in
Google Scholar
PubMed
Search for other papers by Massimo Terzolo in
Google Scholar
PubMed
of onset, severity, seriousness and investigator’s opinion of potential relationship of the event to study drug were recorded. Hormone measurements Steroids in serum To analyze cortisol, 11-deoxycortisol, DHEAS, testosterone and