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Introduction First-line treatment of Cushing’s disease is surgical removal of the ACTH-secreting pituitary tumor and worldwide remission rates range from 60 to 80% ( 1 , 2 , 3 ). The tumor may recur, however, most often within two years of

Introduction Cushing’s disease (CD) is characterized by adrenocorticotropin (ACTH)-dependent cortisol excess originating from a pituitary adenoma and accounts for approximately 85% of cases of pediatric Cushing’s syndrome ( 1 , 2 , 3 , 4

Introduction Cushing’s disease (CD) is a state of cortisol excess, caused by an ACTH-secreting pituitary adenoma. Although a rare disease with an annual incidence of 1.5 patients/million ( 1 ), it is associated with significant morbidity and

Introduction Cushing’s disease (CD) is a subtype of pituitary adenoma with hypercortisolism and presents a particular challenge to neurosurgeons. Transsphenoidal surgery (TS) has long been the standard of care for patients with CD ( 1 , 2

Introduction Hypertension is a common chronic condition in patients with Cushing’s disease (CD) and may be the first sign ( 1 ). The pathogenesis of glucocorticoid-induced hypertension is not fully understood. It is thought to be related in

Introduction Cushing’s disease (CD) is a rare disorder of chronic hypercortisolism exposure caused by an adrenocorticotrophic hormone (ACTH)-secreting pituitary adenoma ( 1 ). Hypercortisolism can induce a variety of physical manifestations

Introduction Transsphenoidal surgery is the treatment of choice in Cushing’s disease (CD). Following removal of the pituitary adenoma, the remission rate varies between 25 and 100% (mean 77.8%, median 78.7%), and the recurrence rate ranges

% diagnostic accuracy ( 1 ). Cushing’s disease (CD) accounts for about 90–95% of the cases when there is no obvious source of ACTH hypersecretion, and this distinction is essential to decide further therapeutic strategies ( 2 , 3 , 4 , 5 ). Sellar imaging

premature aging by inducing accelerated telomere shortening, which might be an explanation for persistent high morbidity and other clinical consequences associated with Cushing’s disease, even years after successful treatment for hypercortisolism. This

(ACTH)-dependent ( 1 ), and 20% is ACTH-independent. Pituitary corticotroph adenoma (Cushing’s disease (CD)) is the most common cause ( 2 ), followed by primary unilateral adrenal adenomas and ectopic adrenocorticotropic syndrome (EAS). The clinical