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Yi Wang
Yi Wang
Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, Beijing, China
National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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Yingying Xu
Yingying Xu
Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
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Rongrong Xie
Rongrong Xie
Department of Endocrinology, Children’s Hospital of Soochow University, Suzhou, China
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Bingyan Cao
Bingyan Cao
Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, Beijing, China
National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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Yuan Ding
Yuan Ding
Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, Beijing, China
National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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Jiayun Guo
Jiayun Guo
Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, Beijing, China
National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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Xiaoqiao Li
Xiaoqiao Li
Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, Beijing, China
National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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Xiaolin Ni
Xiaolin Ni
Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, Beijing, China
National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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Zheng Yuan
Zheng Yuan
Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, Beijing, China
National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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Linqi Chen
Linqi Chen
Department of Endocrinology, Children’s Hospital of Soochow University, Suzhou, China
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Liyang Liang
Liyang Liang
Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
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Chunxiu Gong
Chunxiu Gong
Department of Endocrinology, Genetics and Metabolism, Beijing Children’s Hospital, Capital Medical University, Beijing, China
National Center for Children’s Health, Beijing, China
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National Center for Children’s Health, Beijing, China
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Mygenostics co., LTD, Beijing, China) includes three steps: DNA Library Preparation, targeted genes enrichment and sequencing, and bioinformatics analysis. Approximately 2 mL peripheral blood (EDTA anticoagulant) of the patients and their parents was collected
Nidan Qiao
Nidan Qiao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Haixia Cheng
Haixia Cheng
Department of Pathology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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Zhaoyun Zhang
Zhaoyun Zhang
Department of Endocrinology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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Hongying Ye
Hongying Ye
Department of Endocrinology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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Ming Shen
Ming Shen
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Xuefei Shou
Xuefei Shou
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Xiaoyun Cao
Xiaoyun Cao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Hong Chen
Hong Chen
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
Department of Pathology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
Department of Pathology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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Xiang Zhou
Xiang Zhou
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Yongfei Wang
Yongfei Wang
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Yao Zhao
Yao Zhao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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. Enhanced imaging was performed immediately after administering a standard dose (0.1 mmol/kg) of gadopentetate dimeglumine (Beilu, Beijing, China) at approximately 3–4 mL/s via the dorsal hand or elbow vein. Preoperative definition of cavernous sinus
Shikai Gui
Shikai Gui
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Wanli Yu
Wanli Yu
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Jiabao Xie
Jiabao Xie
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Lunshan Peng
Lunshan Peng
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Yuanyuan Xiong
Yuanyuan Xiong
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
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Zhen Song
Zhen Song
Nanchang University, Nanchang, Jiangxi Province, China
Department of Urology, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
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Department of Urology, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
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Haitao Luo
Haitao Luo
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
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Juexian Xiao
Juexian Xiao
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
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Shengtao Yuan
Shengtao Yuan
Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu Province, China
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Zujue Cheng
Zujue Cheng
Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China
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was obtained from Procell Life Science & Technology (Wuhan, China) and cultured in F-12K (Gibco) supplemented with 15% horse serum (HS) (Procell) and 2.5% fetal bovine serum (FBS) (Procell). The mouse pituitary tumor cell line GT1-1 was obtained from
Jiaxi Li
Jiaxi Li
Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
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Pu Huang
Pu Huang
Department of Health Management Center, Changsha Central Hospital, University of South China, Changsha, Hunan, China
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Jing Xiong
Jing Xiong
Department of Endocrinology, Xiangya Third Hospital, Central South University, Changsha, Hunan, China
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Xinyue Liang
Xinyue Liang
Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
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Mei Li
Mei Li
Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
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Hao Ke
Hao Ke
Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
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Chunli Chen
Chunli Chen
Department of Dermatology, Xiangya Third Hospital, Central South University, Changsha, Hunan, China
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Yang Han
Yang Han
Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
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Yanhong Huang
Yanhong Huang
Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
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Yan Zhou
Yan Zhou
Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
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Ziqiang Luo
Ziqiang Luo
Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Hunan Key Laboratory of Organ Fibrosis, Central South University, Changsha, Hunan, China
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Hunan Key Laboratory of Organ Fibrosis, Central South University, Changsha, Hunan, China
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Dandan Feng
Dandan Feng
Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Hunan Key Laboratory of Organ Fibrosis, Central South University, Changsha, Hunan, China
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Hunan Key Laboratory of Organ Fibrosis, Central South University, Changsha, Hunan, China
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Chen Chen
Chen Chen
School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Queensland, Australia
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and carried out in accordance with the guidelines of the Helsinki Declaration and the legal provisions of China on human clinical research. Written informed consent and assent were obtained from all participants, as appropriate. Participants were
Liang Xue
Liang Xue
Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China
Department of Neurosurgery, 900TH Hospital of the Joint Logistics Support Force, Fuzhou, Fujian, China
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Department of Neurosurgery, 900TH Hospital of the Joint Logistics Support Force, Fuzhou, Fujian, China
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Jianwu Wu
Jianwu Wu
Department of Neurosurgery, 900TH Hospital of the Joint Logistics Support Force, Fuzhou, Fujian, China
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Jie Chen
Jie Chen
Department of Radiology, 900TH Hospital of the Joint Logistics Support Force, Fuzhou, Fujian, China
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Yongkai Yang
Yongkai Yang
Department of Neurosurgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, Fujian, China
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declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. Funding This work was financially supported by Clinical Application Research Project of 900th Hospital, China (No. 2020L
Dan Liang
Dan Liang
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Han Chen
Han Chen
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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Li-Yong Zhong
Li-Yong Zhong
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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-Oncology 2010 100 459 – 463 . ( https://doi.org/10.1007/s11060-010-0206-9 ) 15 Han YT , Dai JP Gao PY Li SW Liu FY MRI findings of germinomas in sellar region . Chinese Journal of Medical Imaging Technology 2000 16 (12) 1034 – 1036
Xiaonan Guo
Xiaonan Guo
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Wenjing Hu
Wenjing Hu
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Xiaorui Lyu
Xiaorui Lyu
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Hanyuan Xu
Hanyuan Xu
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Huijuan Zhu
Huijuan Zhu
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Hui Pan
Hui Pan
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Linjie Wang
Linjie Wang
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Hongbo Yang
Hongbo Yang
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Fengying Gong
Fengying Gong
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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provided by Professor Michael J Waters, University of Queensland, Australia. Lewis wild-type (WT) rats were purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd. (Beijing, China). Lewis heterozygote (dw/+) rats were generated by mating
Lingjuan Li
Lingjuan Li
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Jing Qin
Jing Qin
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Lin Ren
Lin Ren
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Shiyuan Xiang
Shiyuan Xiang
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Xiaoyun Cao
Xiaoyun Cao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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Xianglan Zheng
Xianglan Zheng
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Zhiwen Yin
Zhiwen Yin
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Nidan Qiao
Nidan Qiao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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Purpose
We aimed to describe and predict the risk of severe hypernatremia after surgical resection of craniopharyngioma and to identify the association of water intake, urine output, and sodium level change in the patients.
Method
The outcome was postoperative severe hypernatremia. We identified risk factors associated with hypernatremia using multivariable regression. We trained machine learning models to predict the outcome. We compared serum sodium change, intravenous input, oral input, total input, urine output, and net fluid balance according to different nurse shifts.
Results
Among 234 included patients, 125 developed severe hypernatremia after surgery. The peak incidence occurred during day 0 and day 6 after surgery. The risk was increased in patients with gross total resection (odds ratio (OR) 2.41, P < 0.001), high Puget classification (OR 4.44, P = 0.026), preoperative adrenal insufficiency (OR 2.01, P = 0.040), and preoperative hypernatremia (OR 5.55, P < 0.001). The random forest algorithm had the highest area under the receiver operating characteristic curve (0.770, 95% CI, 0.727–0.813) in predicting the outcome and was validated in the prospective validation cohort. Overnight shifts were associated with the highest serum sodium increase (P = 0.010), less intravenous input (P < 0.001), and less desmopressin use (P < 0.001).
Conclusion
The overall incidence of severe hypernatremia after surgical resection of craniopharyngioma was significant, especially in patients with gross total resection, hypothalamus distortion, preoperative adrenal insufficiency, and preoperative severe hypernatremia. Less intravenous input and less desmopressin use were associated with serum sodium increases, especially during overnight shifts.
Kunzhe Lin
Kunzhe Lin
Department of Neurosurgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, China
Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China
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Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China
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Lingling Lu
Lingling Lu
Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China
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Zhijie Pei
Zhijie Pei
Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China
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Shuwen Mu
Shuwen Mu
Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China
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Shaokuan Huang
Shaokuan Huang
Department of Neurosurgery, Guiqian International General Hospital, Guiyang, China
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Shousen Wang
Shousen Wang
Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China
Department of Neurosurgery, 900th Hospital, Fuzhou, China
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Department of Neurosurgery, 900th Hospital, Fuzhou, China
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Objective
The aim of this study was to evaluate the incidence and duration of delayed hyponatremia and to assess the factors influencing the development of delayed hyponatremia after transsphenoidal surgery (TSS) in pituitary adenomas.
Methods
We retrospectively analyzed the clinical data of patients with pituitary adenoma who underwent TSS. Univariable and multivariable statistics were carried out to identify factors independently associated with the occurrence of delayed hyponatremia.
Results
Of the 285 patients with pituitary adenoma who underwent microscopic TSS, 44 (15.4%) developed postoperative-delayed hyponatremia and 241 (84.6%) did not. The onset of delayed hyponatremia occurred an average of 5.84 days post-surgery and persisted for an average of 5.36 days. Logistic regression analysis showed the highest risk of delayed hyponatremia in patients with significant change in tumor cavity height (odds ratio (OR), 1.158; 95% CI, 1.062, 1.262; P = 0.001), preoperative hypothalamus–pituitary–thyroid axis hypofunction (OR, 3.112; 95% CI, 1.481, 6.539; P = 0.003), and significant difference in blood sodium levels before and 2 days after TSS (OR, 1.101; 95% CI, 1.005, 1.206; P = 0.039).
Conclusions
Preoperative hypothyroidism, difference in blood sodium levels before and 2 days after TSS, and the change in tumor cavity height after TSS played important roles in predicting postoperative-delayed hyponatremia onset in patients with pituitary adenomas.
Ja Hye Kim
Ja Hye Kim
Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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Yunha Choi
Yunha Choi
Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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Soojin Hwang
Soojin Hwang
Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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Ji-Hee Yoon
Ji-Hee Yoon
Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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Jieun Lee
Jieun Lee
Department of Pediatrics, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea
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Min Jae Kang
Min Jae Kang
Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
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Gu-Hwan Kim
Gu-Hwan Kim
Medical Genetics Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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Han-Wook Yoo
Han-Wook Yoo
Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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Jin-Ho Choi
Jin-Ho Choi
Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
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a Brazilian cohort using targeted gene panel sequencing, about 10% of the patients harbored ANOS1 mutations ( 7 ). A single-center study of 210 Chinese patients using direct sequencing of ANOS1 reported a 9% of prevalence of mutations in this
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