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Two weeks of acarbose treatment shows no effect on gut microbiome composition in patients with type 2 diabetes: a randomised, placebo-controlled, double-blind, crossover study

Niels B Dalsgaard

Niels B Dalsgaard Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Lærke S Gasbjerg

Lærke S Gasbjerg Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Laura S Hansen

Laura S Hansen Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Dennis S Nielsen

Dennis S Nielsen Department of Food Science, Faculty of Science, University of Copenhagen, Copenhagen, Denmark

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Torben S Rasmussen

Torben S Rasmussen Department of Food Science, Faculty of Science, University of Copenhagen, Copenhagen, Denmark

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Filip K Knop

Filip K Knop Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Gentofte, Denmark

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course with the alpha-glucosidase inhibitor, acarbose, on GM profiles (evaluated by 16S rRNA gene-based high-throughput sequencing) in Caucasian individuals with metformin-treated T2D. Materials and methods Ethics and study approvals This

Article Type:: Research Article

Collections:: Metabolic Syndrome and Diabetes

DOI:: https://doi.org/10.1530/EC-24-0052

Volume/Issue:: Volume 13: Issue 7

Open access

Impaired colonic motility in high-glycemic diet-induced diabetic mice is associated with disrupted gut microbiota and neuromuscular function

Ying Pei

Ying Pei Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China

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Rui Wang

Rui Wang School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China

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Wanyu Chen

Wanyu Chen Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China

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Shulin Yi

Shulin Yi Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China

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Chen Huang

Chen Huang Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China

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Shaochan Liang

Shaochan Liang School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China

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Hongying Cao

Hongying Cao School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China

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Yifei Xu

Yifei Xu Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China

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Bo Tan

Bo Tan Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China

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.01 vs NFD group. # P < 0.05, ## P < 0.01 vs HGD group. Effects of HGD on the gut microbiota The composition of the gut microbiota was analyzed by bacterial 16S rRNA sequencing of the intestinal feces. After dereplication of unqualified