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% of patients with type 1 diabetes (T1DM) would suffer from DME after 10 years of follow-up ( 5 ). Thyroid dysfunctions, including clinical and subclinical thyroid dysfunction, are common diseases with a prevalence of up to 10% in the general
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suggested that overt hyperthyroidism increases the rate of both bone formation and resorption ( 9 , 11 , 37 ), hypothyroidism results in a low bone turnover state ( 38 ), and subclinical hyper- and hypothyroidism are correlated with bone loss ( 39 , 40
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J Xu M Bi Y et al . Autonomic dysfunction assessed by EZSCAN and subclinical atherosclerosis . Journal of Diabetes 2014 6 409 – 416 . ( https://doi.org/10.1111/1753-0407.12135 ) 9 Luk AO Fu WC Li X Ozaki R Chung HH Wong RY So WY
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involved in platelet dysfunction and facilitating thromboembolism and it can also be reflective of platelet dysfunction in GDM. Therefore, P-selectin is a potential clinical biomarker for innovation of therapy in subclinical inflammatory diseases or
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Department of Internal Medicine, Albany Medical Center Hospital, Albany, New York, USA
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Department of Diabetes and Endocrinology, Royal Liverpool and Broadgreen University NHS Hospital Trust, Liverpool, UK
Division of Endocrinology, Diabetes and Gastroenterology, University of Manchester, Manchester, UK
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Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK
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identify early small nerve fiber loss in patients with DPN ( 18 ) and has demonstrated comparable diagnostic utility to intra-epidermal nerve fiber density ( 4 , 19 , 20 ). A recent meta-analysis has confirmed the diagnostic utility of CCM in subclinical
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Global Health Research Institute, School of Human Development and Health, University of Southampton, Southampton, UK
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causal relationships of low adiponectin levels with dyslipidaemia ( 47 ), coronary artery disease ( 48 ) and CHD ( 49 ) but have found associations with diabetes ( 50 ), sub-clinical atherosclerosis ( 51 ) and insulin resistance ( 52 ). In addition, there