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iodide uptake) reflects iodide transport through the sodium-iodide symporter without the influence of in vivo thyroid iodine organification activity ( 28 ). Thus, in order to evaluate the in vivo NIS function using thyroid radioiodine uptake
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
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Introduction Sodium iodide symporter is a transmembrane glycoprotein (codified by the SLC5A5 gene) expressed almost exclusively in the basolateral plasma membrane of thyroid follicular cells. It plays a central role in thyroid metabolism
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and down-regulates the sodium/iodide symporter gene in Frtl-5 cells . Endocrinology 1999 140 5705 – 5711 . ( https://doi.org/10.1210/endo.140.12.7197 ) 6 Kovacs K Vasarhelyi B Gyarmati B Karvaly G . Estrogen metabolism during pregnancy
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multiple proteins such as thyroid peroxidase (TPO), thyroglobulin (TG), and sodium iodide symporter (NIS) ( 2 , 3 ). NIS is a key protein that mediates active iodine uptake in the thyroid follicular epithelial cells. This procedure is the first critical
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thyroid sodium/iodide symporter activity, causing a decrease in intrathyroid iodide concentration ( 7 ). Thus, there is a therapeutic window between achieved euthyroidism and an escape phenomenon, illustrated by a patient treated with iodine for more than
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iodide into the thyrocytes via the sodium–iodide symporter (NIS), its transport through the cell with pendrin to thyroglobulin (Tg) in the lumen. Iodide oxidation and organification are catalysed by thyroperoxidase (TPO) with H 2 O 2 produced by a dual
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is actively transported into thyrocytes through the activity of the sodium-iodide symporter (NIS) ( 4 ). In the lumen, iodide is oxidized to iodine and incorporated into the tyrosine residues of the thyroglobulin (TG) molecules by the activity of the
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( 18 ). Thiocyanate inhibits the sodium-iodide symporter (NIS), which is responsible for the active uptake of iodide by the thyroid, the gastrointestinal tract, the placenta and the lactating mammary glands ( 19 ). Thiocyanate accumulates in the blood
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-AAG reduced papillary thyroid cancer 1 (PTC1) expression levels and increased radioiodine accumulation in PCCL3 thyroid cells where PTC1 was induced by doxycycline (14) . This was determined to be independent of the sodium iodide symporter (NIS) and
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demonstrated to have effects on thyroidal iodine uptake and TPO activity in animal models ( 31 ). Previous studies suggested that oestradiol might regulate iodide uptake via its action on the sodium/iodide symporter (NIS) and TPO, proteins that play important