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Martin Bidlingmaier Medizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians University, Munich, Germany

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Helena Gleeson Department of Endocrinology, Queen Elizabeth Hospital, Birmingham, UK

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Ana-Claudia Latronico Department of Internal Medicine, Discipline of Endocrinology and Metabolism, Sao Paulo Medical School, University of Sao Paulo, Sao Paulo, Brazil

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Martin O Savage Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK

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clinical management. Radical oncologic surgery (in block) followed by abdominal radiotherapy and chemotherapy (mitotane) can be applied more frequently and earlier in the treatment course in those cases with an aggressive cancer genotype. In addition, the

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Rebeca Esquivel-Zuniga Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA

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Alan D Rogol Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA

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Opiates Endocrine agents: anabolic agents, GnRH analogs and 5 alpha-reductase inhibitors Adrenal enzymatic suppressors: ketoconazole and metyrapone Drugs increasing prolactin: antipsychotics Chemotherapy and/or radiotherapy for

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