Search Results

You are looking at 1 - 10 of 158 items for :

  • "radiotherapy" x
Clear All
Victoria Chatzimavridou-Grigoriadou Department of Endocrinology, Christie Hospital NHS Foundation Trust, Manchester, UK
Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK

Search for other papers by Victoria Chatzimavridou-Grigoriadou in
Google Scholar
PubMed
Close
,
Lisa H Barraclough Department of Endocrinology, Christie Hospital NHS Foundation Trust, Manchester, UK
Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK

Search for other papers by Lisa H Barraclough in
Google Scholar
PubMed
Close
,
Rohit Kochhar Department of Clinical Oncology, Christie Hospital NHS Foundation Trust, Manchester, UK

Search for other papers by Rohit Kochhar in
Google Scholar
PubMed
Close
,
Lucy Buckley Department of Radiology, Christie Hospital NHS Foundation Trust, Manchester, UK

Search for other papers by Lucy Buckley in
Google Scholar
PubMed
Close
,
Nooreen Alam Department of Radiotherapy, Christie Hospital NHS Foundation Trust, Manchester, UK

Search for other papers by Nooreen Alam in
Google Scholar
PubMed
Close
, and
Claire E Higham Department of Endocrinology, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

Search for other papers by Claire E Higham in
Google Scholar
PubMed
Close

Introduction With a constantly rising number of people receiving pelvic radiotherapy for various malignancies, including gynaecological, urological and anorectal, and living long beyond their cancer diagnosis and treatment ( 1 , 2 ), the

Open access
David S McLaren Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospital NHS Trust, Leeds, UK

Search for other papers by David S McLaren in
Google Scholar
PubMed
Close
,
Aarani Devi Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospital NHS Trust, Leeds, UK

Search for other papers by Aarani Devi in
Google Scholar
PubMed
Close
,
Nikolaos Kyriakakis Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospital NHS Trust, Leeds, UK

Search for other papers by Nikolaos Kyriakakis in
Google Scholar
PubMed
Close
,
Michelle Kwok-Williams Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospital NHS Trust, Leeds, UK

Search for other papers by Michelle Kwok-Williams in
Google Scholar
PubMed
Close
, and
Robert D Murray Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospital NHS Trust, Leeds, UK
Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK

Search for other papers by Robert D Murray in
Google Scholar
PubMed
Close

, radiotherapy (RT), chemotherapy, and immunotherapy. Although potentially lifesaving, these interventions often come with their own adverse sequelae that occur both acutely and after a variable duration of time, in some cases decades, following completion of

Open access
Izabelle Lövgren Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK

Search for other papers by Izabelle Lövgren in
Google Scholar
PubMed
Close
,
Azadeh Abravan Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK

Search for other papers by Azadeh Abravan in
Google Scholar
PubMed
Close
,
Abigail Bryce-Atkinson Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK

Search for other papers by Abigail Bryce-Atkinson in
Google Scholar
PubMed
Close
, and
Marcel van Herk Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK

Search for other papers by Marcel van Herk in
Google Scholar
PubMed
Close

proton-beam RT. Table 2 Recent publications on the effects of radiotherapy on the HP axis in paediatric patients. Study Measured outcome Population n Age at treatment RT treatment Radiation dose Follow-up period

Open access
Aleksandra Kukulska Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland
Radiotherapy Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Aleksandra Kukulska in
Google Scholar
PubMed
Close
,
Jolanta Krajewska Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Jolanta Krajewska in
Google Scholar
PubMed
Close
,
Zofia Kolosza Department of Epidemiology and Silesia Cancer Registry, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Zofia Kolosza in
Google Scholar
PubMed
Close
,
Ewa Paliczka-Cieslik Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Ewa Paliczka-Cieslik in
Google Scholar
PubMed
Close
,
Aleksandra Kropinska Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Aleksandra Kropinska in
Google Scholar
PubMed
Close
,
Agnieszka Pawlaczek Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Agnieszka Pawlaczek in
Google Scholar
PubMed
Close
,
Zbigniew Puch Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Zbigniew Puch in
Google Scholar
PubMed
Close
,
Kornelia Ficek Radiotherapy Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Kornelia Ficek in
Google Scholar
PubMed
Close
,
Teresa Lisik Radiotherapy Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Teresa Lisik in
Google Scholar
PubMed
Close
,
Dorota Sygula Radiotherapy Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Dorota Sygula in
Google Scholar
PubMed
Close
,
Zbigniew Wygoda Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Zbigniew Wygoda in
Google Scholar
PubMed
Close
,
Jozef Roskosz Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Jozef Roskosz in
Google Scholar
PubMed
Close
,
Jerzy Wydmanski Radiotherapy Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Jerzy Wydmanski in
Google Scholar
PubMed
Close
, and
Barbara Jarzab Nuclear Medicine and Endocrine Oncology Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland

Search for other papers by Barbara Jarzab in
Google Scholar
PubMed
Close

treatment modalities, including chemo and radiotherapy, demonstrate a limited efficacy in MTC ( 6 ). Radiotherapy may be applied in MTC patients either as an adjuvant treatment or as a palliative approach. Palliative radiotherapy is an effective and accepted

Open access
Laura van Iersel Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

Search for other papers by Laura van Iersel in
Google Scholar
PubMed
Close
,
Sarah C Clement Department of Pediatrics, Amsterdam University Medical Center, location VU University Medical Center, Amsterdam, The Netherlands

Search for other papers by Sarah C Clement in
Google Scholar
PubMed
Close
,
Antoinette Y N Schouten-van Meeteren Department of Pediatric Oncology, Emma Children’s Hospital, Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

Search for other papers by Antoinette Y N Schouten-van Meeteren in
Google Scholar
PubMed
Close
,
Annemieke M Boot Department of Pediatric Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Search for other papers by Annemieke M Boot in
Google Scholar
PubMed
Close
,
Hedi L Claahsen-van der Grinten Department of Pediatric Endocrinology, Amalia Children’s Hospital, Radboud University Medical Center, Nijmegen, The Netherlands

Search for other papers by Hedi L Claahsen-van der Grinten in
Google Scholar
PubMed
Close
,
Bernd Granzen Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands

Search for other papers by Bernd Granzen in
Google Scholar
PubMed
Close
,
K Sen Han Department of Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands

Search for other papers by K Sen Han in
Google Scholar
PubMed
Close
,
Geert O Janssens Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands

Search for other papers by Geert O Janssens in
Google Scholar
PubMed
Close
,
Erna M Michiels Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

Search for other papers by Erna M Michiels in
Google Scholar
PubMed
Close
,
A S Paul van Trotsenburg Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Search for other papers by A S Paul van Trotsenburg in
Google Scholar
PubMed
Close
,
W Peter Vandertop Neurosurgical Center Amsterdam, Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam and location VU University Medical Center, Amsterdam, The Netherlands

Search for other papers by W Peter Vandertop in
Google Scholar
PubMed
Close
,
Dannis G van Vuurden Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Pediatric Oncology/Hematology, Amsterdam University Medical Center, location VU University Medical Center, Amsterdam, The Netherlands

Search for other papers by Dannis G van Vuurden in
Google Scholar
PubMed
Close
,
Hubert N Caron Department of Pediatric Oncology, Emma Children’s Hospital, Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Search for other papers by Hubert N Caron in
Google Scholar
PubMed
Close
,
Leontien C M Kremer Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Pediatrics, Emma Children’s Hospital, Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Search for other papers by Leontien C M Kremer in
Google Scholar
PubMed
Close
, and
Hanneke M van Santen Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

Search for other papers by Hanneke M van Santen in
Google Scholar
PubMed
Close

Introduction Childhood brain tumor survivors (CBTS) have an increased risk of developing central hypothyroidism due to damage of the hypothalamic–pituitary (HP) region, especially after exposure to cranial radiotherapy (cRT) ( 1 , 2 ). The

Open access
Matteo Scopel Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

Search for other papers by Matteo Scopel in
Google Scholar
PubMed
Close
,
Eugenio De Carlo Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

Search for other papers by Eugenio De Carlo in
Google Scholar
PubMed
Close
,
Francesca Bergamo Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

Search for other papers by Francesca Bergamo in
Google Scholar
PubMed
Close
,
Sabina Murgioni Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

Search for other papers by Sabina Murgioni in
Google Scholar
PubMed
Close
,
Riccardo Carandina Radiodiagnostic Unit, University Hospital of Padua, Padua, Italy

Search for other papers by Riccardo Carandina in
Google Scholar
PubMed
Close
,
Anna Rita Cervino Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

Search for other papers by Anna Rita Cervino in
Google Scholar
PubMed
Close
,
Marta Burei Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

Search for other papers by Marta Burei in
Google Scholar
PubMed
Close
,
Federica Vianello Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

Search for other papers by Federica Vianello in
Google Scholar
PubMed
Close
,
Vittorina Zagonel Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

Search for other papers by Vittorina Zagonel in
Google Scholar
PubMed
Close
,
Matteo Fassan Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

Search for other papers by Matteo Fassan in
Google Scholar
PubMed
Close
, and
Roberto Vettor Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

Search for other papers by Roberto Vettor in
Google Scholar
PubMed
Close

compression 2 4 2 8  Fractures or vertebral collapse 2 4 3 12  Asymptomatic 27 57 10 40 Treatment 0.151  Biphosphonates (only) 6 13 6 24  Radiotherapy (only) 5 10

Open access
Joana Simões-Pereira Endocrinology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal

Search for other papers by Joana Simões-Pereira in
Google Scholar
PubMed
Close
,
Daniel Macedo Endocrinology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal

Search for other papers by Daniel Macedo in
Google Scholar
PubMed
Close
, and
Maria João Bugalho Endocrinology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal

Search for other papers by Maria João Bugalho in
Google Scholar
PubMed
Close

. Those patients not eligible for surgery may undergo stereotaxic radiosurgery (SRS) or whole-brain radiotherapy (WBR). RAI can be considered for iodine-avid CNS metastases, under glucocorticoid therapy to minimize the TSH-induced effects and the

Open access
Ravikumar Shah Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

Search for other papers by Ravikumar Shah in
Google Scholar
PubMed
Close
,
Anurag R Lila Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

Search for other papers by Anurag R Lila in
Google Scholar
PubMed
Close
,
Ramteke-Swati Jadhav Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

Search for other papers by Ramteke-Swati Jadhav in
Google Scholar
PubMed
Close
,
Virendra Patil Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

Search for other papers by Virendra Patil in
Google Scholar
PubMed
Close
,
Abhishek Mahajan Department of Radiodiagnosis and Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India

Search for other papers by Abhishek Mahajan in
Google Scholar
PubMed
Close
,
Sushil Sonawane Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

Search for other papers by Sushil Sonawane in
Google Scholar
PubMed
Close
,
Puja Thadani Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

Search for other papers by Puja Thadani in
Google Scholar
PubMed
Close
,
Anil Dcruz Department of Head Neck Surgery, Tata Memorial Hospital, Mumbai, Maharashtra, India

Search for other papers by Anil Dcruz in
Google Scholar
PubMed
Close
,
Prathamesh Pai Department of Head Neck Surgery, Tata Memorial Hospital, Mumbai, Maharashtra, India

Search for other papers by Prathamesh Pai in
Google Scholar
PubMed
Close
,
Munita Bal Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India

Search for other papers by Munita Bal in
Google Scholar
PubMed
Close
,
Subhada Kane Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India

Search for other papers by Subhada Kane in
Google Scholar
PubMed
Close
,
Nalini Shah Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

Search for other papers by Nalini Shah in
Google Scholar
PubMed
Close
, and
Tushar Bandgar Department of Endocrinology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India

Search for other papers by Tushar Bandgar in
Google Scholar
PubMed
Close

–204 months. Patients with persistent/recurrent disease ( n  = 29) were predominantly managed with surgery (65.3%) and/or radiotherapy (30.7%). Among these patients 11 were reported to be alive with no evidence of disease (ANED) and remaining patients were

Open access
Malgorzata Fuksiewicz Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

Search for other papers by Malgorzata Fuksiewicz in
Google Scholar
PubMed
Close
,
Maria Kowalska Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

Search for other papers by Maria Kowalska in
Google Scholar
PubMed
Close
,
Agnieszka Kolasinska-Cwikla Department of Oncology and Radiotherapy, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

Search for other papers by Agnieszka Kolasinska-Cwikla in
Google Scholar
PubMed
Close
, and
Beata Kotowicz Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

Search for other papers by Beata Kotowicz in
Google Scholar
PubMed
Close

The aim of this study was to assess the usefulness of neuron-specific enolase (NSE) concentrations as a prognostic factor in patients with neuroendocrine neoplasms and to determine the relationship between NSE and clinicopathological features. Serum NSE levels were measured in 179 NEN patients before treatment. It was found that NSE levels in patients with a primary pancreatic location were higher compared to patients with a small intestine lesion (P = 0.015). NSE levels were significantly higher in patients with primary pancreatic location with histological grade G2 compared with the group with low-grade G1 (P = 0.047). Patients with initial liver involvement showed significantly higher NSE levels compared to patients with tumour location in the pancreas (P = 0.009). Statistical analysis confirmed that higher NSE levels were associated with disease progression (P = 0.001) in both the overall study group and in patients with tumours in the pancreas and small intestine. During treatment monitoring, an increase in median NSE concentrations was observed in patients with persistent progression with subsequent blood draws, and a decrease in NSE concentrations was observed in patients with disease stabilisation. We showed that NSE concentrations have prognostic value for progression-free survival in addition to primary liver involvement. In conclusion, the most important results of the study include the demonstration of an association between NSE concentrations and clinical status, which confirms its usefulness in patient monitoring and as a potential predictive indicator for progression-free survival in patients with NENs.

Open access
Helga Schultz Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark

Search for other papers by Helga Schultz in
Google Scholar
PubMed
Close
,
Svend Aage Engelholm Department of Radiation Oncology, Rigshospitalet, Copenhagen, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Search for other papers by Svend Aage Engelholm in
Google Scholar
PubMed
Close
,
Eva Harder Department of Oncology and Palliation, Nordsjællands Hospital, Hillerød, Denmark

Search for other papers by Eva Harder in
Google Scholar
PubMed
Close
,
Ulrik Pedersen-Bjergaard Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Search for other papers by Ulrik Pedersen-Bjergaard in
Google Scholar
PubMed
Close
, and
Peter Lommer Kristensen Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark

Search for other papers by Peter Lommer Kristensen in
Google Scholar
PubMed
Close

. If the diagnosis of MSCC is confirmed, the patient is offered either radiotherapy alone or surgical decompression followed by radiotherapy. High-dose glucocorticoid therapy has been proven beneficial as an adjunct to radiotherapy ( 8 ) and is most

Open access