Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK
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Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK
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Introduction With a constantly rising number of people receiving pelvic radiotherapy for various malignancies, including gynaecological, urological and anorectal, and living long beyond their cancer diagnosis and treatment ( 1 , 2 ), the
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Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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, radiotherapy (RT), chemotherapy, and immunotherapy. Although potentially lifesaving, these interventions often come with their own adverse sequelae that occur both acutely and after a variable duration of time, in some cases decades, following completion of
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Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK
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Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK
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proton-beam RT. Table 2 Recent publications on the effects of radiotherapy on the HP axis in paediatric patients. Study Measured outcome Population n Age at treatment RT treatment Radiation dose Follow-up period
Radiotherapy Department, M. Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Gliwice, Poland
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treatment modalities, including chemo and radiotherapy, demonstrate a limited efficacy in MTC ( 6 ). Radiotherapy may be applied in MTC patients either as an adjuvant treatment or as a palliative approach. Palliative radiotherapy is an effective and accepted
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Pediatric Oncology/Hematology, Amsterdam University Medical Center, location VU University Medical Center, Amsterdam, The Netherlands
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Department of Pediatrics, Emma Children’s Hospital, Amsterdam University Medical Center, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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Introduction Childhood brain tumor survivors (CBTS) have an increased risk of developing central hypothyroidism due to damage of the hypothalamic–pituitary (HP) region, especially after exposure to cranial radiotherapy (cRT) ( 1 , 2 ). The
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compression 2 4 2 8 Fractures or vertebral collapse 2 4 3 12 Asymptomatic 27 57 10 40 Treatment 0.151 Biphosphonates (only) 6 13 6 24 Radiotherapy (only) 5 10
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. Those patients not eligible for surgery may undergo stereotaxic radiosurgery (SRS) or whole-brain radiotherapy (WBR). RAI can be considered for iodine-avid CNS metastases, under glucocorticoid therapy to minimize the TSH-induced effects and the
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–204 months. Patients with persistent/recurrent disease ( n = 29) were predominantly managed with surgery (65.3%) and/or radiotherapy (30.7%). Among these patients 11 were reported to be alive with no evidence of disease (ANED) and remaining patients were
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The aim of this study was to assess the usefulness of neuron-specific enolase (NSE) concentrations as a prognostic factor in patients with neuroendocrine neoplasms and to determine the relationship between NSE and clinicopathological features. Serum NSE levels were measured in 179 NEN patients before treatment. It was found that NSE levels in patients with a primary pancreatic location were higher compared to patients with a small intestine lesion (P = 0.015). NSE levels were significantly higher in patients with primary pancreatic location with histological grade G2 compared with the group with low-grade G1 (P = 0.047). Patients with initial liver involvement showed significantly higher NSE levels compared to patients with tumour location in the pancreas (P = 0.009). Statistical analysis confirmed that higher NSE levels were associated with disease progression (P = 0.001) in both the overall study group and in patients with tumours in the pancreas and small intestine. During treatment monitoring, an increase in median NSE concentrations was observed in patients with persistent progression with subsequent blood draws, and a decrease in NSE concentrations was observed in patients with disease stabilisation. We showed that NSE concentrations have prognostic value for progression-free survival in addition to primary liver involvement. In conclusion, the most important results of the study include the demonstration of an association between NSE concentrations and clinical status, which confirms its usefulness in patient monitoring and as a potential predictive indicator for progression-free survival in patients with NENs.
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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. If the diagnosis of MSCC is confirmed, the patient is offered either radiotherapy alone or surgical decompression followed by radiotherapy. High-dose glucocorticoid therapy has been proven beneficial as an adjunct to radiotherapy ( 8 ) and is most