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Inserm UMR1185, Le Kremlin Bicetre, Paris, France
Paris-Saclay University, Paris, France
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failure and infertility. Mini-puberty is a period of neonatal life which corresponds to an early and transient activation of the gonadotropic axis. Several studies have shown that this period is crucial for the early proliferation of Leydig and Sertoli
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increasing NEDD4L-mediated T-bet degradation via ubiquitination ( 22 ). In recent years, accumulating evidence has indicated that NEDD4L contributes to the development of various diseases by regulating cell proliferation. However, the function of NEDDL4 in
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the general population, although the risk in DBA is not as high as in FA or DC/TBD ( 4 ). Anti-Müllerian hormone (AMH) is a glycoprotein in the transforming growth factor-β (TGF-β) superfamily ( 16 , 17 ). AMH is a key factor in cell proliferation
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In bone tissue, INSL3 induces osteoblast proliferation, differentiation, and production of osteoblastic bone formation markers, such as osteonectin, osteocalcin, and alkaline phosphatase ( 59 ). Furthermore, INSL3 reduces the release of sclerostin
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, all the attempts at extraction and proliferation are considered experimental and no clear protocol exists in man, although there is almost 30 years of experience in the rodent ( 82 ). Various ‘adjunctive’ therapies have been tried, including stopping
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myometrial cell proliferation; regulating the expression of the homeobox gene HOXA10 ( 35 ), which is a well-known molecule involved in the mechanism of implantation; promoting immunosuppression, extravillous trophoblast invasion and inducing decidualization
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Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China
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clinical reproductive presentation ( 19 ). Accumulation of small follicles and granulosa cell proliferation due to androgen excess is the probable explanation for the association between AMH and androgen levels ( 37 ). Our study also has some limitations
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Unit of Gynecology and Obstetrics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy
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Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele, Rome, Italy
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Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy
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DM . Testosterone induces cell proliferation and cell cycle gene overexpression in human visceral preadipocytes . American Journal of Physiology. Cell Physiology 2013 305 C355 – C359 . ( https://doi.org/10.1152/ajpcell.00019.2013 ) 13 Blouin K
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drastically decreased number of germ cells even in the prenatal stage. Additionally, the formation of primordial follicles is often impaired and instead replaced by connective tissue proliferation ( 19 ). Total depletion of the oocyte reserve can be already
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National Center of Technology Innovation for Dairy Industry, Hohhot, PR China
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Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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follicular somatic cells or somatic cells and oocytes mediate complex message exchange between cells and are necessary for granulosa cell proliferation, differentiation, and oocyte growth and maturation during follicular development ( 3 , 4 , 5 ). In