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Giuseppe Grande
Giuseppe Grande
Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy
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Andrea Graziani
Andrea Graziani
Department of Medicine, University of Padova, Padova, Italy
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Antonella Di Mambro
Antonella Di Mambro
Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy
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Riccardo Selice
Riccardo Selice
Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy
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Alberto Ferlin
Alberto Ferlin
Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy
Department of Medicine, University of Padova, Padova, Italy
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Department of Medicine, University of Padova, Padova, Italy
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increased in men with primary hypogonadism and in menopausal women with osteoporosis; however, a direct effect of FSH on the bone is not easily discernible, as osteoporosis in these cases is easily attributed to low sex hormone levels. Indeed, clinical
Alan D Rogol
Alan D Rogol
Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA
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puberty ↑AMH Small testes (onset mid-adolescence) Adolescent usually normal testosterone, but ↑ FSH, LH Speech and behavioral problems Adult primary hypogonadism 47,XYY Tall stature FSH ↑ but not to levels in XXY normal or
Lukas Ochsner Ridder
Lukas Ochsner Ridder
Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
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Agnethe Berglund
Agnethe Berglund
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Genetics and Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Clinical Genetics and Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
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Kirstine Stochholm
Kirstine Stochholm
Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
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Simon Chang
Simon Chang
Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark
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Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark
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Claus H Gravholt
Claus H Gravholt
Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark
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Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark
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include all ranges of KS phenotypes. The European Academy of Andrology guidelines on Klinefelter Syndrome recommends that all patients with primary hypogonadism, increased levels of gonadotropins and testis volume < 5 mL, as well as patients with non
Rohit Barnabas
Rohit Barnabas
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Swati Jadhav
Swati Jadhav
Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, India
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Anurag Ranjan Lila
Anurag Ranjan Lila
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Sirisha Kusuma Boddu
Sirisha Kusuma Boddu
Consultant Pediatric Endocrinology & Diabetes, Rainbow Children’s Hospital, Hyderabad, India
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Saba Samad Memon
Saba Samad Memon
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Sneha Arya
Sneha Arya
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Samiksha Chandrashekhar Hegishte
Samiksha Chandrashekhar Hegishte
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Manjiri Karlekar
Manjiri Karlekar
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Virendra A Patil
Virendra A Patil
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Vijaya Sarathi
Vijaya Sarathi
Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, India
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Nalini S Shah
Nalini S Shah
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Tushar Bandgar
Tushar Bandgar
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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pseudohermaphroditism and primary hypogonadism not associated with this . Clinical Endocrinology 1992 36 521 – 522 . ( https://doi.org/10.1111/j.1365-2265.1992.tb02256.x ) 4 Latronico AC & Arnhold IJP . Gonadotropin resistance . Endocrine Development 2013 24
Milou Cecilia Madsen
Milou Cecilia Madsen
Department of Internal Medicine and Center of Expertise on Gender Dysphoria, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
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Martin den Heijer
Martin den Heijer
Department of Internal Medicine and Center of Expertise on Gender Dysphoria, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
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Claudia Pees
Claudia Pees
Walaeus Library, Leiden University Medical Center, Leiden, the Netherlands
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Nienke R Biermasz
Nienke R Biermasz
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Leontine E H Bakker
Leontine E H Bakker
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands
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concentrations in males can lead to a clinical syndrome known as male hypogonadism. This can be caused by testicular disease (primary hypogonadism) or central, pituitary, or hypothalamic disease (secondary hypogonadism). Causes can be genetic, like in Klinefelter
