Search Results
Maki Igarashi
Maki Igarashi
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Maki Igarashi in
Google Scholar
PubMed
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Maki Igarashi in
Google Scholar
PubMed
Tadayuki Ayabe
Tadayuki Ayabe
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Tadayuki Ayabe in
Google Scholar
PubMed
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Tadayuki Ayabe in
Google Scholar
PubMed
Kiwako Yamamoto-Hanada
Kiwako Yamamoto-Hanada
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Kiwako Yamamoto-Hanada in
Google Scholar
PubMed
Search for other papers by Kiwako Yamamoto-Hanada in
Google Scholar
PubMed
Keiko Matsubara
Keiko Matsubara
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Keiko Matsubara in
Google Scholar
PubMed
Search for other papers by Keiko Matsubara in
Google Scholar
PubMed
Hatoko Sasaki
Hatoko Sasaki
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Hatoko Sasaki in
Google Scholar
PubMed
Search for other papers by Hatoko Sasaki in
Google Scholar
PubMed
Mayako Saito-Abe
Mayako Saito-Abe
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Mayako Saito-Abe in
Google Scholar
PubMed
Search for other papers by Mayako Saito-Abe in
Google Scholar
PubMed
Miori Sato
Miori Sato
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Miori Sato in
Google Scholar
PubMed
Search for other papers by Miori Sato in
Google Scholar
PubMed
Nathan Mise
Nathan Mise
Department of Environmental and Preventive Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
Search for other papers by Nathan Mise in
Google Scholar
PubMed
Search for other papers by Nathan Mise in
Google Scholar
PubMed
Akihiko Ikegami
Akihiko Ikegami
Department of Environmental and Preventive Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
Search for other papers by Akihiko Ikegami in
Google Scholar
PubMed
Search for other papers by Akihiko Ikegami in
Google Scholar
PubMed
Masayuki Shimono
Masayuki Shimono
Regional Center for Pilot Study of Japan Environment and Children’s Study, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
Search for other papers by Masayuki Shimono in
Google Scholar
PubMed
Search for other papers by Masayuki Shimono in
Google Scholar
PubMed
Reiko Suga
Reiko Suga
Regional Center for Pilot Study of Japan Environment and Children’s Study, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
Search for other papers by Reiko Suga in
Google Scholar
PubMed
Search for other papers by Reiko Suga in
Google Scholar
PubMed
Shouichi Ohga
Shouichi Ohga
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Research Center for Environment and Developmental Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Search for other papers by Shouichi Ohga in
Google Scholar
PubMed
Research Center for Environment and Developmental Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Search for other papers by Shouichi Ohga in
Google Scholar
PubMed
Masafumi Sanefuji
Masafumi Sanefuji
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Research Center for Environment and Developmental Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Search for other papers by Masafumi Sanefuji in
Google Scholar
PubMed
Research Center for Environment and Developmental Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Search for other papers by Masafumi Sanefuji in
Google Scholar
PubMed
Masako Oda
Masako Oda
Department of Public Health, Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
Search for other papers by Masako Oda in
Google Scholar
PubMed
Search for other papers by Masako Oda in
Google Scholar
PubMed
Hiroshi Mitsubuchi
Hiroshi Mitsubuchi
Department of Neonatology, Kumamoto University Hospital, Chuo-ku, Kumamoto, Japan
Search for other papers by Hiroshi Mitsubuchi in
Google Scholar
PubMed
Search for other papers by Hiroshi Mitsubuchi in
Google Scholar
PubMed
Takehiro Michikawa
Takehiro Michikawa
Japan Environment and Children’s Study Programme Office, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Search for other papers by Takehiro Michikawa in
Google Scholar
PubMed
Search for other papers by Takehiro Michikawa in
Google Scholar
PubMed
Shin Yamazaki
Shin Yamazaki
Japan Environment and Children’s Study Programme Office, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Search for other papers by Shin Yamazaki in
Google Scholar
PubMed
Search for other papers by Shin Yamazaki in
Google Scholar
PubMed
Shoji Nakayama
Shoji Nakayama
Japan Environment and Children’s Study Programme Office, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Search for other papers by Shoji Nakayama in
Google Scholar
PubMed
Search for other papers by Shoji Nakayama in
Google Scholar
PubMed
Yukihiro Ohya
Yukihiro Ohya
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Yukihiro Ohya in
Google Scholar
PubMed
Search for other papers by Yukihiro Ohya in
Google Scholar
PubMed
Maki Fukami
Maki Fukami
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Maki Fukami in
Google Scholar
PubMed
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
Search for other papers by Maki Fukami in
Google Scholar
PubMed
Objective
Ultra-sensitive hormone assays have detected slight sex differences in blood estradiol (E2) levels in young children before adrenarche. However, the origin of circulating E2 in these individuals remains unknown. This study aimed to clarify how E2 is produced in young girls before adrenarche.
Design
This is a satellite project of the Japan Environment and Children’s Study organized by the National Institute for Environmental Studies.
Methods
We collected blood samples from healthy 6-year-old Japanese children (79 boys and 71 girls). Hormone measurements and data analysis were performed in the National Institute for Environmental Studies and the Medical Support Center of the Japan Environment and Children’s Study, respectively.
Results
E2 and follicle stimulating hormone (FSH) levels were significantly higher in girls than in boys, while dehydroepiandrosterone sulfate (DHEA-S) and testosterone levels were comparable between the two groups. Girls showed significantly higher E2/testosterone ratios than boys. In children of both sexes, a correlation was observed between E2 and testosterone levels and between testosterone and DHEA-S levels. Moreover, E2 levels were correlated with FSH levels only in girls.
Conclusions
The results indicate that in 6-year-old girls, circulating E2 is produced primarily in the ovary from adrenal steroids through FSH-induced aromatase upregulation. This study provides evidence that female-dominant E2 production starts several months or years before adrenarche. The biological significance of E2 biosynthesis in these young children needs to be clarified in future studies.
Isabelle Flechtner
Isabelle Flechtner
Center for Rare Gynecological Disorders, Centre des Pathologies Gynécologiques Rares, Paris, France
Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
Search for other papers by Isabelle Flechtner in
Google Scholar
PubMed
Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
Search for other papers by Isabelle Flechtner in
Google Scholar
PubMed
Magali Viaud
Magali Viaud
Center for Rare Gynecological Disorders, Centre des Pathologies Gynécologiques Rares, Paris, France
Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
Search for other papers by Magali Viaud in
Google Scholar
PubMed
Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
Search for other papers by Magali Viaud in
Google Scholar
PubMed
Dulanjalee Kariyawasam
Dulanjalee Kariyawasam
Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
Search for other papers by Dulanjalee Kariyawasam in
Google Scholar
PubMed
Search for other papers by Dulanjalee Kariyawasam in
Google Scholar
PubMed
Marie Perrissin-Fabert
Marie Perrissin-Fabert
Center for Rare Gynecological Disorders, Centre des Pathologies Gynécologiques Rares, Paris, France
Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
Search for other papers by Marie Perrissin-Fabert in
Google Scholar
PubMed
Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
Search for other papers by Marie Perrissin-Fabert in
Google Scholar
PubMed
Maud Bidet
Maud Bidet
Center for Rare Gynecological Disorders, Centre des Pathologies Gynécologiques Rares, Paris, France
Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
Search for other papers by Maud Bidet in
Google Scholar
PubMed
Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
Search for other papers by Maud Bidet in
Google Scholar
PubMed
Anne Bachelot
Anne Bachelot
Center for Rare Gynecological Disorders, Centre des Pathologies Gynécologiques Rares, Paris, France
Department of Endocrinology and Reproductive Medicine, AP-HPIE3M, Hôpital Pitié-Salpêtrière, ICAN, Paris, France
Search for other papers by Anne Bachelot in
Google Scholar
PubMed
Department of Endocrinology and Reproductive Medicine, AP-HPIE3M, Hôpital Pitié-Salpêtrière, ICAN, Paris, France
Search for other papers by Anne Bachelot in
Google Scholar
PubMed
Philippe Touraine
Philippe Touraine
Center for Rare Gynecological Disorders, Centre des Pathologies Gynécologiques Rares, Paris, France
Department of Endocrinology and Reproductive Medicine, AP-HPIE3M, Hôpital Pitié-Salpêtrière, ICAN, Paris, France
Search for other papers by Philippe Touraine in
Google Scholar
PubMed
Department of Endocrinology and Reproductive Medicine, AP-HPIE3M, Hôpital Pitié-Salpêtrière, ICAN, Paris, France
Search for other papers by Philippe Touraine in
Google Scholar
PubMed
Philippe Labrune
Philippe Labrune
Department of Pediatrics, APHP, Centre de Référence des Maladies héréditaires du Métabolisme Hépatique, Hopital Antoine Béclère and Paris Sud University, Clamart, France
Search for other papers by Philippe Labrune in
Google Scholar
PubMed
Search for other papers by Philippe Labrune in
Google Scholar
PubMed
Pascale de Lonlay
Pascale de Lonlay
Reference Center of Inherited Metabolic Diseases, Université de Paris, Necker Enfants Malades, University Hospital, Paris, France
Centre for Rare Gynecological Disorders, Hospital Universitaire Necker-Enfants Malades, Paediatric Endocrinology, Gynaecology and Diabetology, AP-HP, Université de Paris, Paris, France
Search for other papers by Pascale de Lonlay in
Google Scholar
PubMed
Centre for Rare Gynecological Disorders, Hospital Universitaire Necker-Enfants Malades, Paediatric Endocrinology, Gynaecology and Diabetology, AP-HP, Université de Paris, Paris, France
Search for other papers by Pascale de Lonlay in
Google Scholar
PubMed
Michel Polak
Michel Polak
Center for Rare Gynecological Disorders, Centre des Pathologies Gynécologiques Rares, Paris, France
Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
Centre for Rare Gynecological Disorders, Hospital Universitaire Necker-Enfants Malades, Paediatric Endocrinology, Gynaecology and Diabetology, AP-HP, Université de Paris, Paris, France
Search for other papers by Michel Polak in
Google Scholar
PubMed
Department of Paediatric Endocrinology, Gynaecology, and Diabetology, AP-HP, Necker-Enfants Malades University Hospital, IMAGINE Institute affiliate, Paris, France
Centre for Rare Gynecological Disorders, Hospital Universitaire Necker-Enfants Malades, Paediatric Endocrinology, Gynaecology and Diabetology, AP-HP, Université de Paris, Paris, France
Search for other papers by Michel Polak in
Google Scholar
PubMed
Classic galactosemia is a rare inborn error of galactose metabolism with a birth prevalence of about 1/30,000–60,000. Long-term complications occurring despite dietary treatment consist of premature ovarian insufficiency (POI) and neurodevelopmental impairments. We performed with the French Reference Centers for Rare Diseases a multisite collaborative questionnaire survey for classic galactosemic patients. Its primary objective was to assess their puberty, pregnancy, gonadotropic axis, and pelvic morphology by ultrasound. The secondary objective was to determine predictive factors for pregnancy without oocyte donation. Completed questionnaires from 103 patients, 56 females (median age, 19 years (3–52 years)) and 47 males (median age, 19 years (3–45 years)), were analyzed. Among the 43 females older than 13 years old, mean age for breast development first stage was 13.8 years; spontaneous menarche occurred in 21/31 females at a mean age of 14.6 years. In these 21 women, 62% had spaniomenorrhea and 7/17 older than 30 years had amenorrhea. All age-groups confounded, FSH was above reference range for 65.7% of the patients, anti-Müllerian hormone and inhibin B were undetectable, and the ovaries were small with few or no follicles detected. Among the 5 females who sought to conceive, 4 had pregnancies. Among the 47 males, 1 had cryptorchidism, all have normal testicular function and none had a desire to conceive children. Thus, spontaneous puberty and POI are both common in this population. Spontaneous menarche seems to be the best predictive factor for successful spontaneous pregnancy.
Heike Hoyer-Kuhn
Heike Hoyer-Kuhn
Department of Paediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
Search for other papers by Heike Hoyer-Kuhn in
Google Scholar
PubMed
Search for other papers by Heike Hoyer-Kuhn in
Google Scholar
PubMed
Angela Huebner
Angela Huebner
Department of Paediatrics, University Children’s Hospital Dresden, Dresden, Germany
Search for other papers by Angela Huebner in
Google Scholar
PubMed
Search for other papers by Angela Huebner in
Google Scholar
PubMed
Anette Richter-Unruh
Anette Richter-Unruh
University Children’s Hospital Bochum, Bochum, Nordrhein-Westfalen, Germany
Search for other papers by Anette Richter-Unruh in
Google Scholar
PubMed
Search for other papers by Anette Richter-Unruh in
Google Scholar
PubMed
Markus Bettendorf
Markus Bettendorf
University Children’s Hospital Heidelberg, Heidelberg, Germany
Search for other papers by Markus Bettendorf in
Google Scholar
PubMed
Search for other papers by Markus Bettendorf in
Google Scholar
PubMed
Tilman Rohrer
Tilman Rohrer
University Children’s Hospital Homburg, Homburg, Germany
Search for other papers by Tilman Rohrer in
Google Scholar
PubMed
Search for other papers by Tilman Rohrer in
Google Scholar
PubMed
Klaus Kapelari
Klaus Kapelari
University Children’s Hospital Innsbruck, Innsbruck, Austria
Search for other papers by Klaus Kapelari in
Google Scholar
PubMed
Search for other papers by Klaus Kapelari in
Google Scholar
PubMed
Stefan Riedl
Stefan Riedl
Department of Pediatric, Medical University of Vienna, Vienna, Austria
St.Anna Kinderspital, Medical University of Vienna, Vienna, Austria
Search for other papers by Stefan Riedl in
Google Scholar
PubMed
St.Anna Kinderspital, Medical University of Vienna, Vienna, Austria
Search for other papers by Stefan Riedl in
Google Scholar
PubMed
Klaus Mohnike
Klaus Mohnike
Department of Biometrics, Otto von Guericke Universität Magdeburg, Magdeburg, Sachsen-Anhalt, Germany
Search for other papers by Klaus Mohnike in
Google Scholar
PubMed
Search for other papers by Klaus Mohnike in
Google Scholar
PubMed
Helmuth-Günther Dörr
Helmuth-Günther Dörr
University Children’s Hospital Erlangen, Erlangen, Germany
Search for other papers by Helmuth-Günther Dörr in
Google Scholar
PubMed
Search for other papers by Helmuth-Günther Dörr in
Google Scholar
PubMed
Friedrich-Wilhelm Roehl
Friedrich-Wilhelm Roehl
Department of Biometrics, Otto von Guericke Universität Magdeburg, Magdeburg, Sachsen-Anhalt, Germany
Search for other papers by Friedrich-Wilhelm Roehl in
Google Scholar
PubMed
Search for other papers by Friedrich-Wilhelm Roehl in
Google Scholar
PubMed
Katharina Fink
Katharina Fink
Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany
Search for other papers by Katharina Fink in
Google Scholar
PubMed
Search for other papers by Katharina Fink in
Google Scholar
PubMed
Reinhard W Holl
Reinhard W Holl
Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany
Search for other papers by Reinhard W Holl in
Google Scholar
PubMed
Search for other papers by Reinhard W Holl in
Google Scholar
PubMed
Joachim Woelfle
Joachim Woelfle
University Children’s Hospital Erlangen, Erlangen, Germany
Search for other papers by Joachim Woelfle in
Google Scholar
PubMed
Search for other papers by Joachim Woelfle in
Google Scholar
PubMed
with CAH were collected in a standardized database. Later, the German Society for Paediatric Endocrinology and Diabetology (DGKED) took responsibility for the registry (DGKED-QS)). Until now 49 centers have participated in the DGKED-QS registry. Centers
Letícia Ribeiro Oliveira
Letícia Ribeiro Oliveira
Interdisciplinary Group for Studies of Sex Determination and Differentiation (GIEDDS), School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil
Department of Pediatrics, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil
Search for other papers by Letícia Ribeiro Oliveira in
Google Scholar
PubMed
Department of Pediatrics, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil
Search for other papers by Letícia Ribeiro Oliveira in
Google Scholar
PubMed
Carlos Alberto Longui
Carlos Alberto Longui
Pediatric Endocrinology Unit, School of Medical Sciences, Irmandade da Santa Casa de Misericordia de Sao Paulo, Sao Paulo, Brazil
Search for other papers by Carlos Alberto Longui in
Google Scholar
PubMed
Search for other papers by Carlos Alberto Longui in
Google Scholar
PubMed
Guilherme Guaragna-Filho
Guilherme Guaragna-Filho
Interdisciplinary Group for Studies of Sex Determination and Differentiation (GIEDDS), School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil
Department of Pediatrics, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil
Search for other papers by Guilherme Guaragna-Filho in
Google Scholar
PubMed
Department of Pediatrics, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil
Search for other papers by Guilherme Guaragna-Filho in
Google Scholar
PubMed
José Luiz Costa
José Luiz Costa
School of Pharmaceutical Sciences, UNICAMP, Campinas, Sao Paulo, Brazil
Poison Control Center, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by José Luiz Costa in
Google Scholar
PubMed
Poison Control Center, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by José Luiz Costa in
Google Scholar
PubMed
Rafael Lanaro
Rafael Lanaro
Poison Control Center, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by Rafael Lanaro in
Google Scholar
PubMed
Search for other papers by Rafael Lanaro in
Google Scholar
PubMed
David Antônio Silva
David Antônio Silva
Laboratory of Physiology, Division of Clinical Pathology, Clinical Hospital, UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by David Antônio Silva in
Google Scholar
PubMed
Search for other papers by David Antônio Silva in
Google Scholar
PubMed
Maria Izabel Chiamolera
Maria Izabel Chiamolera
Fleury Group, Sao Paulo, Brazil
Search for other papers by Maria Izabel Chiamolera in
Google Scholar
PubMed
Search for other papers by Maria Izabel Chiamolera in
Google Scholar
PubMed
Maricilda Palandi de Mello
Maricilda Palandi de Mello
Interdisciplinary Group for Studies of Sex Determination and Differentiation (GIEDDS), School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil
Laboratory of Human Molecular Genetics, Center for Molecular Biology and Genetics Engineering (CBMEG), UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by Maricilda Palandi de Mello in
Google Scholar
PubMed
Laboratory of Human Molecular Genetics, Center for Molecular Biology and Genetics Engineering (CBMEG), UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by Maricilda Palandi de Mello in
Google Scholar
PubMed
André Moreno Morcillo
André Moreno Morcillo
Department of Pediatrics, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by André Moreno Morcillo in
Google Scholar
PubMed
Search for other papers by André Moreno Morcillo in
Google Scholar
PubMed
Andrea Trevas Maciel-Guerra
Andrea Trevas Maciel-Guerra
Interdisciplinary Group for Studies of Sex Determination and Differentiation (GIEDDS), School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil
Department of Medical Genetics and Genomic Medicine, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by Andrea Trevas Maciel-Guerra in
Google Scholar
PubMed
Department of Medical Genetics and Genomic Medicine, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by Andrea Trevas Maciel-Guerra in
Google Scholar
PubMed
Gil Guerra-Junior
Gil Guerra-Junior
Interdisciplinary Group for Studies of Sex Determination and Differentiation (GIEDDS), School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil
Department of Pediatrics, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by Gil Guerra-Junior in
Google Scholar
PubMed
Department of Pediatrics, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
Search for other papers by Gil Guerra-Junior in
Google Scholar
PubMed
1 Honour JW Steroid assays in paediatric endocrinology . Journal of Clinical Research in Pediatric Endocrinology 2010 2 1 – 16 . ( https://doi.org/10.4274/jcrpe.v2i1.1 ) 21274330 2 Dekkers OM Horváth-Puhó E Cannegieter SC
Anastasia Ibba
Anastasia Ibba
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
Search for other papers by Anastasia Ibba in
Google Scholar
PubMed
Search for other papers by Anastasia Ibba in
Google Scholar
PubMed
Francesca Corrias
Francesca Corrias
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
Search for other papers by Francesca Corrias in
Google Scholar
PubMed
Search for other papers by Francesca Corrias in
Google Scholar
PubMed
Chiara Guzzetti
Chiara Guzzetti
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
Search for other papers by Chiara Guzzetti in
Google Scholar
PubMed
Search for other papers by Chiara Guzzetti in
Google Scholar
PubMed
Letizia Casula
Letizia Casula
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
Search for other papers by Letizia Casula in
Google Scholar
PubMed
Search for other papers by Letizia Casula in
Google Scholar
PubMed
Mariacarolina Salerno
Mariacarolina Salerno
Dipartimento di Pediatria, Università Federico II, Napoli, Italy
Search for other papers by Mariacarolina Salerno in
Google Scholar
PubMed
Search for other papers by Mariacarolina Salerno in
Google Scholar
PubMed
Natascia di Iorgi
Natascia di Iorgi
Dipartimento di Pediatria, IRCCS Istituto Giannina Gaslini, Università di Genova, Genova, Italy
Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
Search for other papers by Natascia di Iorgi in
Google Scholar
PubMed
Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
Search for other papers by Natascia di Iorgi in
Google Scholar
PubMed
Gianluca Tornese
Gianluca Tornese
SSD Endocrinologia Pediatrica, Clinica Pediatrica, IRCCS Materno-infantile Burlo Garofolo, Trieste, Italy
Search for other papers by Gianluca Tornese in
Google Scholar
PubMed
Search for other papers by Gianluca Tornese in
Google Scholar
PubMed
Giuseppa Patti
Giuseppa Patti
Dipartimento di Pediatria, IRCCS Istituto Giannina Gaslini, Università di Genova, Genova, Italy
Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
Search for other papers by Giuseppa Patti in
Google Scholar
PubMed
Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
Search for other papers by Giuseppa Patti in
Google Scholar
PubMed
Giorgio Radetti
Giorgio Radetti
Dipartimento di Pediatria, Ospedale Generale Regionale, Bolzano, Italy
Search for other papers by Giorgio Radetti in
Google Scholar
PubMed
Search for other papers by Giorgio Radetti in
Google Scholar
PubMed
Mohamad Maghnie
Mohamad Maghnie
Dipartimento di Pediatria, IRCCS Istituto Giannina Gaslini, Università di Genova, Genova, Italy
Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
Search for other papers by Mohamad Maghnie in
Google Scholar
PubMed
Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
Search for other papers by Mohamad Maghnie in
Google Scholar
PubMed
Marco Cappa
Marco Cappa
UOC di Endocrinologia, Dipartimento Universitario Ospedaliero, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Italy
Search for other papers by Marco Cappa in
Google Scholar
PubMed
Search for other papers by Marco Cappa in
Google Scholar
PubMed
Sandro Loche
Sandro Loche
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
Search for other papers by Sandro Loche in
Google Scholar
PubMed
Search for other papers by Sandro Loche in
Google Scholar
PubMed
summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop . Journal of Clinical Endocrinology and Metabolism 2008 93 4210 – 4217 . ( https
Min Yang
Min Yang
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Min Yang in
Google Scholar
PubMed
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Min Yang in
Google Scholar
PubMed
Xiangling Deng
Xiangling Deng
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Xiangling Deng in
Google Scholar
PubMed
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Xiangling Deng in
Google Scholar
PubMed
Shunan Wang
Shunan Wang
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Shunan Wang in
Google Scholar
PubMed
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Shunan Wang in
Google Scholar
PubMed
Bo Zhou
Bo Zhou
Graduate School, Beijing University of Chinese Medicine, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Bo Zhou in
Google Scholar
PubMed
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Bo Zhou in
Google Scholar
PubMed
Wenquan Niu
Wenquan Niu
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Wenquan Niu in
Google Scholar
PubMed
Search for other papers by Wenquan Niu in
Google Scholar
PubMed
Zhixin Zhang
Zhixin Zhang
International Medical Services, China-Japan Friendship Hospital, Beijing, China
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Zhixin Zhang in
Google Scholar
PubMed
Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
Search for other papers by Zhixin Zhang in
Google Scholar
PubMed
aged 7–18 years: a nation-wide survey in China, 2014 . BMJ Open 2019 9 e026634. ( https://doi.org/10.1136/bmjopen-2018-026634 ) 5 Thomsett MJ The spectrum of clinical paediatric endocrinology: 28 years of referrals to an individual consultant
Mirjana Doknic
Mirjana Doknic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Mirjana Doknic in
Google Scholar
PubMed
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Mirjana Doknic in
Google Scholar
PubMed
Marko Stojanovic
Marko Stojanovic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Marko Stojanovic in
Google Scholar
PubMed
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Marko Stojanovic in
Google Scholar
PubMed
Ivan Soldatovic
Ivan Soldatovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Institute of Medical Statistics and Informatics, Belgrade, Serbia
Search for other papers by Ivan Soldatovic in
Google Scholar
PubMed
Institute of Medical Statistics and Informatics, Belgrade, Serbia
Search for other papers by Ivan Soldatovic in
Google Scholar
PubMed
Tatjana Milenkovic
Tatjana Milenkovic
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
Search for other papers by Tatjana Milenkovic in
Google Scholar
PubMed
Search for other papers by Tatjana Milenkovic in
Google Scholar
PubMed
Vera Zdravkovic
Vera Zdravkovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
University Children’s Clinic, Belgrade, Serbia
Search for other papers by Vera Zdravkovic in
Google Scholar
PubMed
University Children’s Clinic, Belgrade, Serbia
Search for other papers by Vera Zdravkovic in
Google Scholar
PubMed
Maja Jesic
Maja Jesic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
University Children’s Clinic, Belgrade, Serbia
Search for other papers by Maja Jesic in
Google Scholar
PubMed
University Children’s Clinic, Belgrade, Serbia
Search for other papers by Maja Jesic in
Google Scholar
PubMed
Sladjana Todorovic
Sladjana Todorovic
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
Search for other papers by Sladjana Todorovic in
Google Scholar
PubMed
Search for other papers by Sladjana Todorovic in
Google Scholar
PubMed
Katarina Mitrovic
Katarina Mitrovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
Search for other papers by Katarina Mitrovic in
Google Scholar
PubMed
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
Search for other papers by Katarina Mitrovic in
Google Scholar
PubMed
Rade Vukovic
Rade Vukovic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
Search for other papers by Rade Vukovic in
Google Scholar
PubMed
Mother and Child Health Care Institute of Serbia ‘Dr Vukan Cupic’, Belgrade, Serbia
Search for other papers by Rade Vukovic in
Google Scholar
PubMed
Dragana Miljic
Dragana Miljic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Dragana Miljic in
Google Scholar
PubMed
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Dragana Miljic in
Google Scholar
PubMed
Dragan Savic
Dragan Savic
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Dragan Savic in
Google Scholar
PubMed
Search for other papers by Dragan Savic in
Google Scholar
PubMed
Mihajlo Milicevic
Mihajlo Milicevic
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Mihajlo Milicevic in
Google Scholar
PubMed
Search for other papers by Mihajlo Milicevic in
Google Scholar
PubMed
Aleksandar Stanimirovic
Aleksandar Stanimirovic
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Aleksandar Stanimirovic in
Google Scholar
PubMed
Search for other papers by Aleksandar Stanimirovic in
Google Scholar
PubMed
Vojislav Bogosavljevic
Vojislav Bogosavljevic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Vojislav Bogosavljevic in
Google Scholar
PubMed
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Vojislav Bogosavljevic in
Google Scholar
PubMed
Sandra Pekic
Sandra Pekic
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Sandra Pekic in
Google Scholar
PubMed
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Sandra Pekic in
Google Scholar
PubMed
Emilija Manojlovic-Gacic
Emilija Manojlovic-Gacic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Emilija Manojlovic-Gacic in
Google Scholar
PubMed
Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Emilija Manojlovic-Gacic in
Google Scholar
PubMed
Aleksandar Djukic
Aleksandar Djukic
Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Search for other papers by Aleksandar Djukic in
Google Scholar
PubMed
Search for other papers by Aleksandar Djukic in
Google Scholar
PubMed
Danica Grujicic
Danica Grujicic
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Danica Grujicic in
Google Scholar
PubMed
Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia
Search for other papers by Danica Grujicic in
Google Scholar
PubMed
Milan Petakov
Milan Petakov
Neuroendocrine Department, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, Serbia
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Milan Petakov in
Google Scholar
PubMed
Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Search for other papers by Milan Petakov in
Google Scholar
PubMed
Monson JP Shalet SM Tauber M & European Society of Paediatric Endocrinology. Consensus statement on the management of the GH-treated adolescent in the transition to adult care . European Journal of Endocrinology 2005 152 165 – 170 . ( https
