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). However, real-world data about the optimal LDL-C target level for preventing CVE in this very high-risk population is insufficient. In particular, the debate over the clinical benefits of LDL-C lowering in older patients with diabetes for secondary
German Center for Diabetes Research (DZD), Neuherberg, Germany
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Department of Internal Medicine IV, University Hospital Tübingen, Germany
Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany
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Division of Endocrinology and Diabetology, Department of Internal Medicine 1, University Hospital Ulm, Ulm, Germany
Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen, Tübingen, Germany
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Institute of Health Services Research and Health Economics, Center for Health and Society, Faculty of Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Institute of Health Services Research and Health Economics, German Diabetes Center (DDZ), Leibniz Centre for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
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addition, it is possible that the increase in hospitalizations in older patients results in fewer beds available for the younger age groups. The increase of hospitalizations among younger adults (20–39 years) with diabetes, also observed in the US ( 9
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% in older patients suggesting a more aggressive disease process in younger individuals ( 25 ). Different proportions of circulating lymphocyte subpopulations, for example, CD8 T cells, have as well been observed ( 26 ). In some patients, inflammation
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. ( https://doi.org/10.1111/jdi.13864 ) 36 Mattishent K Loke YK . Meta-analysis: association Between hypoglycemia and serious adverse events in older patients treated with glucose-lowering agents . Frontiers in Endocrinology (Lausanne) 2021 12