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Department of Internal Medicine, HagaHospital, The Hague, The Netherlands
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Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
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conflicting results from large observational studies. Therefore, the aim of this study is to investigate whether kidney function modifies the association of subclinical thyroid dysfunction and the risk of cardiovascular outcomes in older patients
Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
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University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital, Basel, Switzerland
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Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
Faculty of Medicine, University Hospital Basel, Basel, Switzerland
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Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
Faculty of Medicine, University Hospital Basel, Basel, Switzerland
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Division of General and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau AG, Aarau, Switzerland
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undertreatment of PTX in older patients with pHPT ( 7 ). PTX should be performed in patients with symptomatic pHPT ( 8 ). Importantly, the vast majority of diagnosed cases in western countries are asymptomatic ( 9 ), thus not presenting with clinically manifest
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Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
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Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
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Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China
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). Therefore, this study aimed to analyze the correlations between serum ferritin levels and NAFLD in middle-aged and older patients with T2DM in order to further explore a new biological marker for the diagnosis and treatment of T2DM patients with NAFLD
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). However, real-world data about the optimal LDL-C target level for preventing CVE in this very high-risk population is insufficient. In particular, the debate over the clinical benefits of LDL-C lowering in older patients with diabetes for secondary
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Medicine Department, Basque Country University, Bilbao, Spain
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Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain
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CIBEROBN, Madrid, Spain
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Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
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Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain
University of Alcalá, Madrid, Spain
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the CYP11B2 immunohistochemistry should be incorporated into the routine clinical diagnostic workup to localize the likely source of aldosterone production ( 10 ). In addition, in older patients, the aldosterone-renin ratio (ARR) increases, mainly
Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia
Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Caldas, Colombia
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Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia
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Dinamica IPS, Medellín, Antioquia, Colombia
University of California Davis Comprehensive Cancer Center, Sacramento, California, USA
Fundación de Genética y Genómica, Medellín, Antioquia, Colombia
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on outcome in older patients with papillary thyroid cancer . Surgery 2014 137 – 146 . ( https://doi.org/10.1016/j.surg.2014.03.027 ) 46 Loh KC Greenspan FS Gee L Miller TR Yeo PP . Pathological tumor-node-metastasis (pTNM) staging
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Université Pierre et Marie Curie, Sorbonne Université, Paris, France
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INSERM UMR_S933, Paris, France
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Université Pierre et Marie Curie, Sorbonne Université, Paris, France
INSERM UMR_S933, Paris, France
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Human 3 beta-hydroxysteroid dehydrogenase deficiency (3b-HSD) is a very rare form of congenital adrenal hyperplasia resulting from HSD3B2 gene mutations. The estimated prevalence is less than 1/1,000,000 at birth. It leads to steroidogenesis impairment in both adrenals and gonads. Few data are available concerning adult testicular function in such patients. We had the opportunity to study gonadal axis and testicular function in a 46,XY adult patient, carrying a HSD3B2 mutation. He presented at birth a neonatal salt-wasting syndrome. He had a micropenis, a perineal hypospadias and two intrascrotal testes. HSD3B2 gene sequencing revealed a 687del27 homozygous mutation. The patient achieved normal puberty at the age of 15 years. Transition from the paediatric department occurred at the age of 19 years. His hormonal profile under hydrocortisone and fludrocortisone treatments revealed normal serum levels of 17OH-pregnenolone, as well as SDHEA, ACTH, total testosterone, inhibin B and AMH. Pelvic ultrasound identified two scrotal testes of 21 mL each, without any testicular adrenal rest tumours. His adult spermatic characteristics were normal, according to WHO 2010 criteria, with a sperm concentration of 57.6 million/mL (N > 15), 21% of typical forms (N > 4%). Sperm vitality was subnormal (41%; N > 58%). This patient, in contrast to previous reports, presents subnormal sperm parameters and therefore potential male fertility in a 24-years-old patient with severe 3b-HSD deficiency. This case should improve counselling about fertility of male patients carrying HSD3B2 mutation.
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-related alterations in drug metabolism and the presence of a higher number of comorbidities can affect both the expected efficacy and the adverse effects of treatments other than somatostatin analogs (SSAs). Older patients are substantially underrepresented in
INSERM U1018, Université Paris Sud, Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse, Bât 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Paris, Villejuif Cedex, France
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intensive glycaemic control does not reduce the risk of CVD in older patients with long-standing type 2 diabetes (13, 25, 26) . As type 2 diabetes affects cognitive function, intensive diabetes control may prevent the onset of microvascular disease in the
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Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark
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perception and physical role functioning scores also increased, though not significantly so until the 6 months visit ( P values at 6 months were 0.0003 and 0.047, respectively). The only significant changes observed in the older patients were social role